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Validation of a New Retinopathy of Prematurity Screening Method Monitoring Longitudinal Postnatal Weight and Insulinlike Growth Factor I

Loqvist, Chatarina ; Pupp, Ingrid LU orcid ; Andersson, Eva ; Holm, Kristina LU ; Smith, Lois E. H. ; Ley, David LU and Hellstrom, Ann (2009) In Archives of Ophthalmology 127(5). p.622-627
Abstract
Objective: To validate in a prospective study the surveillance algorithm WINROP for detecting infants at risk for proliferative retinopathy of prematurity (ROP). Methods: Fifty preterm infants with a mean gestational age of 26 weeks were included. In the first step of WINROP, weekly measures of body weight and serum insulinlike growth factor I (IGF-I) level from birth until postmenstrual age 36 weeks are entered and compared with expected development. If any of the variables show a negative deviation to a certain degree, an alarm is given. In the second step, gestational age, birth weight, and IGF binding protein 3 level are entered. Results: The WINROP algorithm identified all children (100% sensitivity) who were diagnosed with... (More)
Objective: To validate in a prospective study the surveillance algorithm WINROP for detecting infants at risk for proliferative retinopathy of prematurity (ROP). Methods: Fifty preterm infants with a mean gestational age of 26 weeks were included. In the first step of WINROP, weekly measures of body weight and serum insulinlike growth factor I (IGF-I) level from birth until postmenstrual age 36 weeks are entered and compared with expected development. If any of the variables show a negative deviation to a certain degree, an alarm is given. In the second step, gestational age, birth weight, and IGF binding protein 3 level are entered. Results: The WINROP algorithm identified all children (100% sensitivity) who were diagnosed with proliferative ROP 1.1 to 21.6 weeks later. No infants with no alarm or with alarm at low risk developed proliferative ROP. Alarm at high risk before postmenstrual age 32 weeks was given for 22 of 50 infants (44%); 9 of these infants developed proliferative ROP (54% specificity), of whom 8 were treated. Conclusion: The WINROP algorithm may be a useful tool for modification of ROP screening. (Less)
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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Algorithms, Biomarkers/blood, Birth Weight/physiology, False Positive Reactions, Female, Gestational Age, Humans, Infant, Infant, Newborn, Infant, Premature/blood, Insulin-Like Growth Factor Binding Protein 3/blood, Insulin-Like Growth Factor I/analysis, Male, Predictive Value of Tests, Prospective Studies, Radioimmunoassay, Reproducibility of Results, Retinopathy of Prematurity/blood, Risk Factors, Sensitivity and Specificity
in
Archives of Ophthalmology
volume
127
issue
5
pages
6 pages
publisher
American Medical Association
external identifiers
  • wos:000265847700004
  • scopus:65649119585
  • pmid:19433710
ISSN
0003-9950
DOI
10.1001/archophthalmol.2009.69
language
English
LU publication?
yes
id
6ff1cdda-fc7a-46f5-87c1-649b532e29d5 (old id 1426466)
date added to LUP
2016-04-01 11:47:37
date last changed
2023-09-29 10:07:59
@article{6ff1cdda-fc7a-46f5-87c1-649b532e29d5,
  abstract     = {{Objective: To validate in a prospective study the surveillance algorithm WINROP for detecting infants at risk for proliferative retinopathy of prematurity (ROP). Methods: Fifty preterm infants with a mean gestational age of 26 weeks were included. In the first step of WINROP, weekly measures of body weight and serum insulinlike growth factor I (IGF-I) level from birth until postmenstrual age 36 weeks are entered and compared with expected development. If any of the variables show a negative deviation to a certain degree, an alarm is given. In the second step, gestational age, birth weight, and IGF binding protein 3 level are entered. Results: The WINROP algorithm identified all children (100% sensitivity) who were diagnosed with proliferative ROP 1.1 to 21.6 weeks later. No infants with no alarm or with alarm at low risk developed proliferative ROP. Alarm at high risk before postmenstrual age 32 weeks was given for 22 of 50 infants (44%); 9 of these infants developed proliferative ROP (54% specificity), of whom 8 were treated. Conclusion: The WINROP algorithm may be a useful tool for modification of ROP screening.}},
  author       = {{Loqvist, Chatarina and Pupp, Ingrid and Andersson, Eva and Holm, Kristina and Smith, Lois E. H. and Ley, David and Hellstrom, Ann}},
  issn         = {{0003-9950}},
  keywords     = {{Algorithms; Biomarkers/blood; Birth Weight/physiology; False Positive Reactions; Female; Gestational Age; Humans; Infant; Infant, Newborn; Infant, Premature/blood; Insulin-Like Growth Factor Binding Protein 3/blood; Insulin-Like Growth Factor I/analysis; Male; Predictive Value of Tests; Prospective Studies; Radioimmunoassay; Reproducibility of Results; Retinopathy of Prematurity/blood; Risk Factors; Sensitivity and Specificity}},
  language     = {{eng}},
  number       = {{5}},
  pages        = {{622--627}},
  publisher    = {{American Medical Association}},
  series       = {{Archives of Ophthalmology}},
  title        = {{Validation of a New Retinopathy of Prematurity Screening Method Monitoring Longitudinal Postnatal Weight and Insulinlike Growth Factor I}},
  url          = {{http://dx.doi.org/10.1001/archophthalmol.2009.69}},
  doi          = {{10.1001/archophthalmol.2009.69}},
  volume       = {{127}},
  year         = {{2009}},
}