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Low levels of IgM antibodies against phosphorylcholine-A potential risk marker for ischemic stroke in men

Sjoberg, Beatrice G.; Su, Jun; Dahlbom, Ingrid; Gronlund, Hans; Wikstrom, Max; Hedblad, Bo LU ; Berglund, Göran LU ; de Faire, Ulf and Frostegard, Johan (2009) In Atherosclerosis 203(2). p.528-532
Abstract
Background: Natural antibodies specific for phosphorylcholine (anti-PC) have been implicated as protective factors in atherosclerosis. We herein determined the relationship between IgM anti-PC and incidence of cardiovascular disease (CVD). Methods: We studied 349 incident cases (200 men) of first events of CVD (coronary heart disease (CHD; n = 203 or ischemic stroke; n = 146) and 693 age- and sex-matched controls identified through 12 years of follow-up (1991-2003) of subjects from the cardiovascular cohort within the Malmo Diet and Cancer Study. Relative risks (RR) of CVD with 95% confidence intervals (CI) of incident CVD with adjustments for age, smoking, total cholesterol and blood pressure were determined. Anti-PC-levels were measured... (More)
Background: Natural antibodies specific for phosphorylcholine (anti-PC) have been implicated as protective factors in atherosclerosis. We herein determined the relationship between IgM anti-PC and incidence of cardiovascular disease (CVD). Methods: We studied 349 incident cases (200 men) of first events of CVD (coronary heart disease (CHD; n = 203 or ischemic stroke; n = 146) and 693 age- and sex-matched controls identified through 12 years of follow-up (1991-2003) of subjects from the cardiovascular cohort within the Malmo Diet and Cancer Study. Relative risks (RR) of CVD with 95% confidence intervals (CI) of incident CVD with adjustments for age, smoking, total cholesterol and blood pressure were determined. Anti-PC-levels were measured using ELISA (Athera CVDefine (TM)). Results: As determined using Athera CVDefine (TM), significant associations were attained with values of anti-PC below 17 U/ml (corresponding to the lowest 9th percentile), which remained after taking confounders into account (RR: 1.79, 95% CI: 1.09-2.94, p=0.021). If men were studied separately, significance was evident at values below 17U/ml (RR: 2.01, 95% Cl: 1.11-3.67, p=0.022), which was not the case among women. Furthermore, values below 17 U/ml were also associated with ischemic stroke (RR = 3.67, 95% Cl: 1.34-10.1, p=0.01), but not with CHD. Conclusion: Low IgM anti-PC could be a novel risk marker for development of ischemic stroke in men. Further studies are needed to establish gender and subgroup differences. (C) 2008 Elsevier Ireland Ltd. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Immune system, Phosphorylcholine, Cardiovascular disease, Antibodies, Risk marker
in
Atherosclerosis
volume
203
issue
2
pages
528 - 532
publisher
Elsevier
external identifiers
  • wos:000265464800031
  • scopus:62649133717
ISSN
1879-1484
DOI
10.1016/j.atherosclerosis.2008.07.009
language
English
LU publication?
yes
id
77127abf-c276-405b-b4cd-265eef5651e4 (old id 1428108)
date added to LUP
2009-06-25 13:18:15
date last changed
2017-10-29 03:37:05
@article{77127abf-c276-405b-b4cd-265eef5651e4,
  abstract     = {Background: Natural antibodies specific for phosphorylcholine (anti-PC) have been implicated as protective factors in atherosclerosis. We herein determined the relationship between IgM anti-PC and incidence of cardiovascular disease (CVD). Methods: We studied 349 incident cases (200 men) of first events of CVD (coronary heart disease (CHD; n = 203 or ischemic stroke; n = 146) and 693 age- and sex-matched controls identified through 12 years of follow-up (1991-2003) of subjects from the cardiovascular cohort within the Malmo Diet and Cancer Study. Relative risks (RR) of CVD with 95% confidence intervals (CI) of incident CVD with adjustments for age, smoking, total cholesterol and blood pressure were determined. Anti-PC-levels were measured using ELISA (Athera CVDefine (TM)). Results: As determined using Athera CVDefine (TM), significant associations were attained with values of anti-PC below 17 U/ml (corresponding to the lowest 9th percentile), which remained after taking confounders into account (RR: 1.79, 95% CI: 1.09-2.94, p=0.021). If men were studied separately, significance was evident at values below 17U/ml (RR: 2.01, 95% Cl: 1.11-3.67, p=0.022), which was not the case among women. Furthermore, values below 17 U/ml were also associated with ischemic stroke (RR = 3.67, 95% Cl: 1.34-10.1, p=0.01), but not with CHD. Conclusion: Low IgM anti-PC could be a novel risk marker for development of ischemic stroke in men. Further studies are needed to establish gender and subgroup differences. (C) 2008 Elsevier Ireland Ltd. All rights reserved.},
  author       = {Sjoberg, Beatrice G. and Su, Jun and Dahlbom, Ingrid and Gronlund, Hans and Wikstrom, Max and Hedblad, Bo and Berglund, Göran and de Faire, Ulf and Frostegard, Johan},
  issn         = {1879-1484},
  keyword      = {Immune system,Phosphorylcholine,Cardiovascular disease,Antibodies,Risk marker},
  language     = {eng},
  number       = {2},
  pages        = {528--532},
  publisher    = {Elsevier},
  series       = {Atherosclerosis},
  title        = {Low levels of IgM antibodies against phosphorylcholine-A potential risk marker for ischemic stroke in men},
  url          = {http://dx.doi.org/10.1016/j.atherosclerosis.2008.07.009},
  volume       = {203},
  year         = {2009},
}