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Impact of transposable elements on the evolution of mammalian gene regulation.

Medstrand, Patrik LU ; van de Lagemaat, L N; Dunn, C A; Landry, J-R; Svenback, Daniel LU and Mager, D L (2005) In Cytogenetic and Genome Research 110(1-4). p.342-352
Abstract
Transposable elements (TEs) are present in all organisms and nearly half of the human and mouse genome is derived from ancient transpositions. This fact alone suggests that TEs have played a major role in genome organization and evolution. Studies undertaken over the last two decades or so clearly show that TEs of various kinds have played an important role in organism evolution. Here we review the impact TEs have on the evolution Of gene regulation and gene function with an emphasis on humans. Understanding the mechanisms resulting in genomic change is central to our understanding of gene regulation, genetic disease and genome evolution. Full comprehension of these biological processes is not possible without an in depth knowledge of how... (More)
Transposable elements (TEs) are present in all organisms and nearly half of the human and mouse genome is derived from ancient transpositions. This fact alone suggests that TEs have played a major role in genome organization and evolution. Studies undertaken over the last two decades or so clearly show that TEs of various kinds have played an important role in organism evolution. Here we review the impact TEs have on the evolution Of gene regulation and gene function with an emphasis on humans. Understanding the mechanisms resulting in genomic change is central to our understanding of gene regulation, genetic disease and genome evolution. Full comprehension of these biological processes is not possible without an in depth knowledge of how TEs impact upon the genome. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Cytogenetic and Genome Research
volume
110
issue
1-4
pages
342 - 352
publisher
Karger
external identifiers
  • wos:000231064600034
  • pmid:16093686
  • scopus:23844534414
ISSN
1424-859X
DOI
10.1159/000084966
language
English
LU publication?
yes
id
53d32d2f-5483-43fe-a193-2715736a9aff (old id 142848)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16093686&dopt=Abstract
date added to LUP
2007-07-18 09:49:42
date last changed
2017-11-05 03:47:17
@article{53d32d2f-5483-43fe-a193-2715736a9aff,
  abstract     = {Transposable elements (TEs) are present in all organisms and nearly half of the human and mouse genome is derived from ancient transpositions. This fact alone suggests that TEs have played a major role in genome organization and evolution. Studies undertaken over the last two decades or so clearly show that TEs of various kinds have played an important role in organism evolution. Here we review the impact TEs have on the evolution Of gene regulation and gene function with an emphasis on humans. Understanding the mechanisms resulting in genomic change is central to our understanding of gene regulation, genetic disease and genome evolution. Full comprehension of these biological processes is not possible without an in depth knowledge of how TEs impact upon the genome.},
  author       = {Medstrand, Patrik and van de Lagemaat, L N and Dunn, C A and Landry, J-R and Svenback, Daniel and Mager, D L},
  issn         = {1424-859X},
  language     = {eng},
  number       = {1-4},
  pages        = {342--352},
  publisher    = {Karger},
  series       = {Cytogenetic and Genome Research},
  title        = {Impact of transposable elements on the evolution of mammalian gene regulation.},
  url          = {http://dx.doi.org/10.1159/000084966},
  volume       = {110},
  year         = {2005},
}