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Heparan sulphate proteoglycans: the sweet side of development.

Häcker, Udo LU ; Nybakken, Kent and Perrimon, Norbert (2005) In Nature Reviews. Molecular Cell Biology 6(7). p.530-541
Abstract
Pattern formation during development is controlled to a great extent by a small number of conserved signal transduction pathways that are activated by extracellular ligands such as Hedgehog, Wingless or Decapentaplegic. Genetic experiments have identified heparan sulphate proteoglycans (HSPGs) as important regulators of the tissue distribution of these extracellular signalling molecules. Several recent reports provide important new insights into the mechanisms by which HSPGs function during development.
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organization
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Contribution to journal
publication status
published
subject
keywords
Glycosaminoglycans: biosynthesis, Gene Expression Regulation, Animals, N.I.H., U.S. Gov't, P.H.S., Signal Transduction, Non-U.S. Gov't, Research Support, Extramural, Heparan Sulfate Proteoglycan: genetics, Heparan Sulfate Proteoglycan: physiology, Humans, Mutation
in
Nature Reviews. Molecular Cell Biology
volume
6
issue
7
pages
530 - 541
publisher
Nature Publishing Group
external identifiers
  • wos:000230245700010
  • pmid:16072037
  • scopus:21744450786
ISSN
1471-0072
DOI
10.1038/nrm1681
language
English
LU publication?
yes
id
6df48a69-7216-4a48-910e-c123b3a6bfcd (old id 143007)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16072037&dopt=Abstract
date added to LUP
2007-07-13 14:08:25
date last changed
2017-10-01 04:48:03
@article{6df48a69-7216-4a48-910e-c123b3a6bfcd,
  abstract     = {Pattern formation during development is controlled to a great extent by a small number of conserved signal transduction pathways that are activated by extracellular ligands such as Hedgehog, Wingless or Decapentaplegic. Genetic experiments have identified heparan sulphate proteoglycans (HSPGs) as important regulators of the tissue distribution of these extracellular signalling molecules. Several recent reports provide important new insights into the mechanisms by which HSPGs function during development.},
  author       = {Häcker, Udo and Nybakken, Kent and Perrimon, Norbert},
  issn         = {1471-0072},
  keyword      = {Glycosaminoglycans: biosynthesis,Gene Expression Regulation,Animals,N.I.H.,U.S. Gov't,P.H.S.,Signal Transduction,Non-U.S. Gov't,Research Support,Extramural,Heparan Sulfate Proteoglycan: genetics,Heparan Sulfate Proteoglycan: physiology,Humans,Mutation},
  language     = {eng},
  number       = {7},
  pages        = {530--541},
  publisher    = {Nature Publishing Group},
  series       = {Nature Reviews. Molecular Cell Biology},
  title        = {Heparan sulphate proteoglycans: the sweet side of development.},
  url          = {http://dx.doi.org/10.1038/nrm1681},
  volume       = {6},
  year         = {2005},
}