Advanced

Intra-individual variations and temporal trends in dioxin levels in human blood 1987-2002.

Rylander, Lars LU ; Hagmar, Lars LU ; Wallin, Ewa LU ; Sjöström, Anna Kitti and Tysklind, Mats (2009) In Chemosphere 76. p.1557-1562
Abstract
OBJECTIVES: In Sweden, an important source for exposure to persistent organochlorine pollutants, such as PCDD and PCDF, is through intake of fatty fish from the Baltic Sea off the Eastern coast of Sweden. The present study assesses temporal trends for human levels of PCDD/F between 1987 and 2002 among 26 men from Sweden. In addition, we investigate the impact of potential determinants (age, relative change in BMI and fish consumption) on the relatively change in individual PCDD/F congener levels between 1987 and 2002. METHODS: In 1987, nine of the men did not eat fatty fish from the Baltic Sea, eight had a moderate intake, and nine were high consumers. For the same individuals, blood samples were collected in 1987 as well as in 2002, and... (More)
OBJECTIVES: In Sweden, an important source for exposure to persistent organochlorine pollutants, such as PCDD and PCDF, is through intake of fatty fish from the Baltic Sea off the Eastern coast of Sweden. The present study assesses temporal trends for human levels of PCDD/F between 1987 and 2002 among 26 men from Sweden. In addition, we investigate the impact of potential determinants (age, relative change in BMI and fish consumption) on the relatively change in individual PCDD/F congener levels between 1987 and 2002. METHODS: In 1987, nine of the men did not eat fatty fish from the Baltic Sea, eight had a moderate intake, and nine were high consumers. For the same individuals, blood samples were collected in 1987 as well as in 2002, and the concentrations of seven PCDD and 10 PCDF congeners were analyzed at the same laboratory. RESULTS: The WHO-TEQ levels for PCDD/F did not significantly change over the 15-year period. There were, however, some specific congeners that significantly had changed over time. None of the investigated determinants were associated with the change over time for the specific PCDD/F congeners. CONCLUSION: The present study may be of importance for risk assessment and setting standards for food contamination with PCDD/F, especially regarding intake of fatty fish from the Baltic Sea. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Chemosphere
volume
76
pages
1557 - 1562
publisher
Elsevier
external identifiers
  • wos:000270124800016
  • pmid:19559463
  • scopus:68949131107
ISSN
1879-1298
DOI
10.1016/j.chemosphere.2009.05.036
language
English
LU publication?
yes
id
e7949192-b239-4380-b92c-bdfe0f1c696c (old id 1433808)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19559463?dopt=Abstract
date added to LUP
2009-07-06 11:34:06
date last changed
2017-01-01 07:39:26
@article{e7949192-b239-4380-b92c-bdfe0f1c696c,
  abstract     = {OBJECTIVES: In Sweden, an important source for exposure to persistent organochlorine pollutants, such as PCDD and PCDF, is through intake of fatty fish from the Baltic Sea off the Eastern coast of Sweden. The present study assesses temporal trends for human levels of PCDD/F between 1987 and 2002 among 26 men from Sweden. In addition, we investigate the impact of potential determinants (age, relative change in BMI and fish consumption) on the relatively change in individual PCDD/F congener levels between 1987 and 2002. METHODS: In 1987, nine of the men did not eat fatty fish from the Baltic Sea, eight had a moderate intake, and nine were high consumers. For the same individuals, blood samples were collected in 1987 as well as in 2002, and the concentrations of seven PCDD and 10 PCDF congeners were analyzed at the same laboratory. RESULTS: The WHO-TEQ levels for PCDD/F did not significantly change over the 15-year period. There were, however, some specific congeners that significantly had changed over time. None of the investigated determinants were associated with the change over time for the specific PCDD/F congeners. CONCLUSION: The present study may be of importance for risk assessment and setting standards for food contamination with PCDD/F, especially regarding intake of fatty fish from the Baltic Sea.},
  author       = {Rylander, Lars and Hagmar, Lars and Wallin, Ewa and Sjöström, Anna Kitti and Tysklind, Mats},
  issn         = {1879-1298},
  language     = {eng},
  pages        = {1557--1562},
  publisher    = {Elsevier},
  series       = {Chemosphere},
  title        = {Intra-individual variations and temporal trends in dioxin levels in human blood 1987-2002.},
  url          = {http://dx.doi.org/10.1016/j.chemosphere.2009.05.036},
  volume       = {76},
  year         = {2009},
}