Endostatin predicts mortality in patients with acute dyspnea – A cohort study of patients seeking care in emergency departments
(2020) In Clinical Biochemistry 75. p.35-39- Abstract
Background: Increased levels of circulating endostatin predicts cardiovascular morbidity and impaired kidney function in the general population. The utility of endostatin as a risk marker for mortality in the emergency department (ED) has not been reported. Aim: Our main aim was to study the association between plasma endostatin and 90-day mortality in an unselected cohort of patients admitted to the ED for acute dyspnea. Design Circulating endostatin was analyzed in plasma from 1710 adults and related to 90-day mortality in Cox proportional hazard models adjusted for age, sex, body mass index, oxygen saturation, respiratory rate, body temperature, C-reactive protein, lactate, creatinine and medical priority according to the Medical... (More)
Background: Increased levels of circulating endostatin predicts cardiovascular morbidity and impaired kidney function in the general population. The utility of endostatin as a risk marker for mortality in the emergency department (ED) has not been reported. Aim: Our main aim was to study the association between plasma endostatin and 90-day mortality in an unselected cohort of patients admitted to the ED for acute dyspnea. Design Circulating endostatin was analyzed in plasma from 1710 adults and related to 90-day mortality in Cox proportional hazard models adjusted for age, sex, body mass index, oxygen saturation, respiratory rate, body temperature, C-reactive protein, lactate, creatinine and medical priority according to the Medical Emergency Triage and Treatment System–Adult score (METTS-A). The predictive value of endostatin for mortality was evaluated with receiver operating characteristic (ROC) analysis and compared with the clinical triage scoring system and age. Results: Each one standard deviation increment of endostatin was associated with a HR of 2.12 (95% CI 1.31–3.44 p < 0.01) for 90-day mortality after full adjustment. Levels of endostatin were significantly increased in the group of patients with highest METTS-A (p < 0.001). When tested for the outcome 90-day mortality, the area under the ROC curve (AUC) was 0.616 for METTS-A, 0.701 for endostatin, 0.708 for METTS -A and age and 0.738 for METTS-A, age and levels of endostatin. Conclusions: In an unselected cohort of patients admitted to the ED with acute dyspnea, endostatin had a string association to 90-day mortality and improved prediction of 90-day mortality in the ED beyond the clinical triage scoring system and age with 3%.
(Less)
- author
- Carlsson, A. C. ; Wessman, T. LU ; Larsson, A. ; Leijonberg, G. ; Tofik, R. LU ; Ärnlöv, J. ; Melander, O. LU and Ruge, T. LU
- organization
- publishing date
- 2020-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Acute dyspnea, Cardiovascular, Emergency department, Endostatin, Epidemiology, METTS-A, Mortality
- in
- Clinical Biochemistry
- volume
- 75
- pages
- 5 pages
- publisher
- Elsevier
- external identifiers
-
- pmid:31672650
- scopus:85075435893
- ISSN
- 0009-9120
- DOI
- 10.1016/j.clinbiochem.2019.10.004
- language
- English
- LU publication?
- yes
- id
- 1433826b-d921-4fd4-841d-312c5263ae83
- date added to LUP
- 2019-12-09 09:03:07
- date last changed
- 2024-09-18 14:55:02
@article{1433826b-d921-4fd4-841d-312c5263ae83, abstract = {{<p>Background: Increased levels of circulating endostatin predicts cardiovascular morbidity and impaired kidney function in the general population. The utility of endostatin as a risk marker for mortality in the emergency department (ED) has not been reported. Aim: Our main aim was to study the association between plasma endostatin and 90-day mortality in an unselected cohort of patients admitted to the ED for acute dyspnea. Design Circulating endostatin was analyzed in plasma from 1710 adults and related to 90-day mortality in Cox proportional hazard models adjusted for age, sex, body mass index, oxygen saturation, respiratory rate, body temperature, C-reactive protein, lactate, creatinine and medical priority according to the Medical Emergency Triage and Treatment System–Adult score (METTS-A). The predictive value of endostatin for mortality was evaluated with receiver operating characteristic (ROC) analysis and compared with the clinical triage scoring system and age. Results: Each one standard deviation increment of endostatin was associated with a HR of 2.12 (95% CI 1.31–3.44 p < 0.01) for 90-day mortality after full adjustment. Levels of endostatin were significantly increased in the group of patients with highest METTS-A (p < 0.001). When tested for the outcome 90-day mortality, the area under the ROC curve (AUC) was 0.616 for METTS-A, 0.701 for endostatin, 0.708 for METTS -A and age and 0.738 for METTS-A, age and levels of endostatin. Conclusions: In an unselected cohort of patients admitted to the ED with acute dyspnea, endostatin had a string association to 90-day mortality and improved prediction of 90-day mortality in the ED beyond the clinical triage scoring system and age with 3%.</p>}}, author = {{Carlsson, A. C. and Wessman, T. and Larsson, A. and Leijonberg, G. and Tofik, R. and Ärnlöv, J. and Melander, O. and Ruge, T.}}, issn = {{0009-9120}}, keywords = {{Acute dyspnea; Cardiovascular; Emergency department; Endostatin; Epidemiology; METTS-A; Mortality}}, language = {{eng}}, pages = {{35--39}}, publisher = {{Elsevier}}, series = {{Clinical Biochemistry}}, title = {{Endostatin predicts mortality in patients with acute dyspnea – A cohort study of patients seeking care in emergency departments}}, url = {{http://dx.doi.org/10.1016/j.clinbiochem.2019.10.004}}, doi = {{10.1016/j.clinbiochem.2019.10.004}}, volume = {{75}}, year = {{2020}}, }