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The porcine retinal vasculature can be accessed using an endovascular approach, a new experimental model for retinal ischemia.

Morén, Håkan LU ; Undrén, Per; Gesslein, Bodil LU ; Olivecrona, Göran LU ; Andréasson, Sten LU and Malmsjö, Malin LU (2009) In Investigative Ophthalmology & Visual Science 50(11). p.5504-5510
Abstract
Purpose. The aim was to examine if the retinal circulation in the pig can be accessed using interventional neuroradiology and to explore the possibility to create occlusions that result in experimental retinal ischemia. Methods. Six experiments were performed using 100 kg pigs. The external carotid system was catheterizised using fluoroscopy monitored, transfemoral, endovascular approach. Transient and permanent vascular occlusions were performed using an angioplasty balloon catheter or a liquid embolic agent that was administered via an injection-catheter. Results. A technique for transfemoral catheterization of arteries supplying the retina was established. The ophthalmic artery was demonstrated to give rise to the main ciliary artery,... (More)
Purpose. The aim was to examine if the retinal circulation in the pig can be accessed using interventional neuroradiology and to explore the possibility to create occlusions that result in experimental retinal ischemia. Methods. Six experiments were performed using 100 kg pigs. The external carotid system was catheterizised using fluoroscopy monitored, transfemoral, endovascular approach. Transient and permanent vascular occlusions were performed using an angioplasty balloon catheter or a liquid embolic agent that was administered via an injection-catheter. Results. A technique for transfemoral catheterization of arteries supplying the retina was established. The ophthalmic artery was demonstrated to give rise to the main ciliary artery, from which the retinal artery branched as a single or several arteries. A balloon-catheter could be introduced into the ophthalmic artery, but not into the main ciliary artery. An injection-catheter could, in all experiments, be introduced into the main ciliary artery and, in some experiments, into the retinal artery. Occlusion of the ophthalmic artery, over the branching of the main ciliary artery, caused incomplete ischemia, presumably due to collaterals feeding the distal parts of the vasculature. mfERG recordings showed decreased amplitudes and increased implicit times, indicating retinal ischemia. Occlusion of the ciliary and retinal arteries caused complete ischemia, as shown by complete flattening of the mfERG recordings and, by indirect ophthalmoscopy, blanching of the retinal arteries and a pale retina Conclusions. We prove for the first time that the ophthalmic and retinal artery can be catheterizised using a transfemoral endovascular approach. This technique may be useful to produce clear-cut experimental retinal ischemia. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Investigative Ophthalmology & Visual Science
volume
50
issue
11
pages
5504 - 5510
publisher
ASSOC RESEARCH VISION OPHTHALMOLOGY INC
external identifiers
  • wos:000271429200064
  • pmid:19516013
  • scopus:77952099566
ISSN
1552-5783
DOI
10.1167/iovs.09-3529
language
English
LU publication?
yes
id
763a3dcd-053b-4f35-95fe-696b5e05db39 (old id 1434342)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19516013?dopt=Abstract
date added to LUP
2009-07-03 14:37:46
date last changed
2017-01-01 06:11:48
@article{763a3dcd-053b-4f35-95fe-696b5e05db39,
  abstract     = {Purpose. The aim was to examine if the retinal circulation in the pig can be accessed using interventional neuroradiology and to explore the possibility to create occlusions that result in experimental retinal ischemia. Methods. Six experiments were performed using 100 kg pigs. The external carotid system was catheterizised using fluoroscopy monitored, transfemoral, endovascular approach. Transient and permanent vascular occlusions were performed using an angioplasty balloon catheter or a liquid embolic agent that was administered via an injection-catheter. Results. A technique for transfemoral catheterization of arteries supplying the retina was established. The ophthalmic artery was demonstrated to give rise to the main ciliary artery, from which the retinal artery branched as a single or several arteries. A balloon-catheter could be introduced into the ophthalmic artery, but not into the main ciliary artery. An injection-catheter could, in all experiments, be introduced into the main ciliary artery and, in some experiments, into the retinal artery. Occlusion of the ophthalmic artery, over the branching of the main ciliary artery, caused incomplete ischemia, presumably due to collaterals feeding the distal parts of the vasculature. mfERG recordings showed decreased amplitudes and increased implicit times, indicating retinal ischemia. Occlusion of the ciliary and retinal arteries caused complete ischemia, as shown by complete flattening of the mfERG recordings and, by indirect ophthalmoscopy, blanching of the retinal arteries and a pale retina Conclusions. We prove for the first time that the ophthalmic and retinal artery can be catheterizised using a transfemoral endovascular approach. This technique may be useful to produce clear-cut experimental retinal ischemia.},
  author       = {Morén, Håkan and Undrén, Per and Gesslein, Bodil and Olivecrona, Göran and Andréasson, Sten and Malmsjö, Malin},
  issn         = {1552-5783},
  language     = {eng},
  number       = {11},
  pages        = {5504--5510},
  publisher    = {ASSOC RESEARCH VISION OPHTHALMOLOGY INC},
  series       = {Investigative Ophthalmology & Visual Science},
  title        = {The porcine retinal vasculature can be accessed using an endovascular approach, a new experimental model for retinal ischemia.},
  url          = {http://dx.doi.org/10.1167/iovs.09-3529},
  volume       = {50},
  year         = {2009},
}