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The value of animal models in predicting genetic susceptibility to complex diseases such as rheumatoid arthritis.

Ahlqvist, Emma LU ; Hultqvist, Malin LU and Holmdahl, Rikard LU (2009) In Arthritis Research and Therapy 11(3).
Abstract
ABSTRACT: For a long time, genetic studies of complex diseases were most successfully conducted in animal models. However, the field of genetics is now rapidly evolving, and human genetics has also started to produce strong candidate genes for complex diseases. This raises the question of how to continue gene-finding attempts in animals and how to use animal models to enhance our understanding of gene function. In this review we summarize the uses and advantages of animal studies in identification of disease susceptibility genes, focusing on rheumatoid arthritis. We are convinced that animal genetics will remain a valuable tool for the identification and investigation of pathways that lead to disease, well into the future.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Arthritis Research and Therapy
volume
11
issue
3
publisher
BioMed Central
external identifiers
  • wos:000269019300012
  • pmid:19490601
  • scopus:65949083562
ISSN
1478-6362
DOI
10.1186/ar2600
language
English
LU publication?
yes
id
06a3068c-5b3c-41e5-9a9b-1ac765bab715 (old id 1434624)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19490601?dopt=Abstract
date added to LUP
2009-07-02 12:36:34
date last changed
2017-01-01 07:33:04
@article{06a3068c-5b3c-41e5-9a9b-1ac765bab715,
  abstract     = {ABSTRACT: For a long time, genetic studies of complex diseases were most successfully conducted in animal models. However, the field of genetics is now rapidly evolving, and human genetics has also started to produce strong candidate genes for complex diseases. This raises the question of how to continue gene-finding attempts in animals and how to use animal models to enhance our understanding of gene function. In this review we summarize the uses and advantages of animal studies in identification of disease susceptibility genes, focusing on rheumatoid arthritis. We are convinced that animal genetics will remain a valuable tool for the identification and investigation of pathways that lead to disease, well into the future.},
  articleno    = {226},
  author       = {Ahlqvist, Emma and Hultqvist, Malin and Holmdahl, Rikard},
  issn         = {1478-6362},
  language     = {eng},
  number       = {3},
  publisher    = {BioMed Central},
  series       = {Arthritis Research and Therapy},
  title        = {The value of animal models in predicting genetic susceptibility to complex diseases such as rheumatoid arthritis.},
  url          = {http://dx.doi.org/10.1186/ar2600},
  volume       = {11},
  year         = {2009},
}