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Serum chlamydial lipopolysaccharide as a prognostic factor for a new cardiovascular event.

Pesonen, Erkki LU ; Tiirola, Terttu; Andsberg, Eeva; Jauhiainen, Matti; Paldanius, Matti; Persson, Kenneth LU ; Saikku, Pekka; Sarna, Seppo; Öhlin, Hans LU and Leinonen, Maija (2009) In Heart & Lung 38(3). p.176-181
Abstract
BACKGROUND: Infections caused by Chlamydia pneumoniae are considered to participate in inflammatory processes leading to coronary artery disease. After a primary infection, the bacteria remain dormant intracellularly causing a chronic inflammatory stimulus. MATERIALS AND METHODS: Blood samples were obtained from 235 patients with acute myocardial infarction (AMI) and 108 patients with unstable angina pectoris (UA). We evaluated the prognostic significance of bacterial and viral antibody titers, serum troponin T, C-reactive protein, and chlamydial lipopolysaccharide (cLPS) concentrations during acute coronary syndrome of patients with AMI and UA for cardiovascular death and new UA and AMI that required hospital care during a 6-year... (More)
BACKGROUND: Infections caused by Chlamydia pneumoniae are considered to participate in inflammatory processes leading to coronary artery disease. After a primary infection, the bacteria remain dormant intracellularly causing a chronic inflammatory stimulus. MATERIALS AND METHODS: Blood samples were obtained from 235 patients with acute myocardial infarction (AMI) and 108 patients with unstable angina pectoris (UA). We evaluated the prognostic significance of bacterial and viral antibody titers, serum troponin T, C-reactive protein, and chlamydial lipopolysaccharide (cLPS) concentrations during acute coronary syndrome of patients with AMI and UA for cardiovascular death and new UA and AMI that required hospital care during a 6-year follow-up. RESULTS: Serum cLPS levels correlated with C-reactive protein and serum troponin T concentrations during acute coronary events. Patients with AMI had significantly higher serum concentration of cLPS compared with patients with UA. Enterovirus antibody titers and cholesterol-lowering therapy at admission of the index event were negatively correlated with cLPS concentration (r = -.198, P = .0003 and r = -.26, P = .019, respectively). The presence of circulating cLPS was associated with a hazard ratio of 2.04 for a new cardiovascular event during the follow-up period (P = .006). The area under the curve in the receiver operating graph was .572. CONCLUSION: cLPS is evidently liberated from the infected atherosclerotic tissue during an acute coronary event. Our study supports the view that inflammation caused by C. pneumoniae infection is an important but as yet poorly understood factor in the development of atherosclerosis and may play a role in acute vascular events. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Heart & Lung
volume
38
issue
3
pages
176 - 181
publisher
Mosby
external identifiers
  • wos:000266618400003
  • pmid:19486785
  • scopus:66449119708
ISSN
1527-3288
DOI
10.1016/j.hrtlng.2008.06.001
language
English
LU publication?
yes
id
32bcefd7-01c9-4542-8a34-18ce69b430a2 (old id 1434667)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19486785?dopt=Abstract
date added to LUP
2009-07-02 12:57:20
date last changed
2017-01-01 07:36:16
@article{32bcefd7-01c9-4542-8a34-18ce69b430a2,
  abstract     = {BACKGROUND: Infections caused by Chlamydia pneumoniae are considered to participate in inflammatory processes leading to coronary artery disease. After a primary infection, the bacteria remain dormant intracellularly causing a chronic inflammatory stimulus. MATERIALS AND METHODS: Blood samples were obtained from 235 patients with acute myocardial infarction (AMI) and 108 patients with unstable angina pectoris (UA). We evaluated the prognostic significance of bacterial and viral antibody titers, serum troponin T, C-reactive protein, and chlamydial lipopolysaccharide (cLPS) concentrations during acute coronary syndrome of patients with AMI and UA for cardiovascular death and new UA and AMI that required hospital care during a 6-year follow-up. RESULTS: Serum cLPS levels correlated with C-reactive protein and serum troponin T concentrations during acute coronary events. Patients with AMI had significantly higher serum concentration of cLPS compared with patients with UA. Enterovirus antibody titers and cholesterol-lowering therapy at admission of the index event were negatively correlated with cLPS concentration (r = -.198, P = .0003 and r = -.26, P = .019, respectively). The presence of circulating cLPS was associated with a hazard ratio of 2.04 for a new cardiovascular event during the follow-up period (P = .006). The area under the curve in the receiver operating graph was .572. CONCLUSION: cLPS is evidently liberated from the infected atherosclerotic tissue during an acute coronary event. Our study supports the view that inflammation caused by C. pneumoniae infection is an important but as yet poorly understood factor in the development of atherosclerosis and may play a role in acute vascular events.},
  author       = {Pesonen, Erkki and Tiirola, Terttu and Andsberg, Eeva and Jauhiainen, Matti and Paldanius, Matti and Persson, Kenneth and Saikku, Pekka and Sarna, Seppo and Öhlin, Hans and Leinonen, Maija},
  issn         = {1527-3288},
  language     = {eng},
  number       = {3},
  pages        = {176--181},
  publisher    = {Mosby},
  series       = {Heart & Lung},
  title        = {Serum chlamydial lipopolysaccharide as a prognostic factor for a new cardiovascular event.},
  url          = {http://dx.doi.org/10.1016/j.hrtlng.2008.06.001},
  volume       = {38},
  year         = {2009},
}