Hippocampal theta activity during encoding promotes subsequent associative memory in humans
(2023) In Cerebral Cortex 33(13). p.8792-8802- Abstract
Hippocampal theta oscillations have been implicated in associative memory in humans. However, findings from electrophysiological studies using scalp electroencephalography or magnetoencephalography, and those using intracranial electroencephalography are mixed. Here we asked 10 pre-surgical epilepsy patients undergoing intracranial electroencephalography recording, along with 21 participants undergoing magnetoencephalography recordings, to perform an associative memory task, and examined whether hippocampal theta activity during encoding was predictive of subsequent associative memory performance. Across the intracranial electroencephalography and magnetoencephalography studies, we observed that theta power in the hippocampus increased... (More)
Hippocampal theta oscillations have been implicated in associative memory in humans. However, findings from electrophysiological studies using scalp electroencephalography or magnetoencephalography, and those using intracranial electroencephalography are mixed. Here we asked 10 pre-surgical epilepsy patients undergoing intracranial electroencephalography recording, along with 21 participants undergoing magnetoencephalography recordings, to perform an associative memory task, and examined whether hippocampal theta activity during encoding was predictive of subsequent associative memory performance. Across the intracranial electroencephalography and magnetoencephalography studies, we observed that theta power in the hippocampus increased during encoding, and that this increase differed as a function of subsequent memory, with greater theta activity for pairs that were successfully retrieved in their entirety compared with those that were not remembered. This helps to clarify the role of theta oscillations in associative memory formation in humans, and further, demonstrates that findings in epilepsy patients undergoing intracranial electroencephalography recordings can be extended to healthy participants undergoing magnetoencephalography recordings.
(Less)
- author
- Joensen, Bárður H. LU ; Bush, Daniel ; Vivekananda, Umesh ; Horner, Aidan J. ; Bisby, James A. ; Diehl, Beate ; Miserocchi, Anna ; Mcevoy, Andrew W. ; Walker, Matthew C. and Burgess, Neil
- publishing date
- 2023-07-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- associative memory, hippocampus, intracranial EEG, MEG, theta oscillations
- in
- Cerebral Cortex
- volume
- 33
- issue
- 13
- pages
- 11 pages
- publisher
- Oxford University Press
- external identifiers
-
- pmid:37160345
- scopus:85162044610
- ISSN
- 1047-3211
- DOI
- 10.1093/cercor/bhad162
- language
- English
- LU publication?
- no
- additional info
- Publisher Copyright: © 2023 The Author(s). Published by Oxford University Press.
- id
- 143a9903-436a-4578-bdc4-57cf8f70b28a
- date added to LUP
- 2024-03-18 11:49:10
- date last changed
- 2024-06-10 14:57:16
@article{143a9903-436a-4578-bdc4-57cf8f70b28a,
abstract = {{<p>Hippocampal theta oscillations have been implicated in associative memory in humans. However, findings from electrophysiological studies using scalp electroencephalography or magnetoencephalography, and those using intracranial electroencephalography are mixed. Here we asked 10 pre-surgical epilepsy patients undergoing intracranial electroencephalography recording, along with 21 participants undergoing magnetoencephalography recordings, to perform an associative memory task, and examined whether hippocampal theta activity during encoding was predictive of subsequent associative memory performance. Across the intracranial electroencephalography and magnetoencephalography studies, we observed that theta power in the hippocampus increased during encoding, and that this increase differed as a function of subsequent memory, with greater theta activity for pairs that were successfully retrieved in their entirety compared with those that were not remembered. This helps to clarify the role of theta oscillations in associative memory formation in humans, and further, demonstrates that findings in epilepsy patients undergoing intracranial electroencephalography recordings can be extended to healthy participants undergoing magnetoencephalography recordings.</p>}},
author = {{Joensen, Bárður H. and Bush, Daniel and Vivekananda, Umesh and Horner, Aidan J. and Bisby, James A. and Diehl, Beate and Miserocchi, Anna and Mcevoy, Andrew W. and Walker, Matthew C. and Burgess, Neil}},
issn = {{1047-3211}},
keywords = {{associative memory; hippocampus; intracranial EEG; MEG; theta oscillations}},
language = {{eng}},
month = {{07}},
number = {{13}},
pages = {{8792--8802}},
publisher = {{Oxford University Press}},
series = {{Cerebral Cortex}},
title = {{Hippocampal theta activity during encoding promotes subsequent associative memory in humans}},
url = {{http://dx.doi.org/10.1093/cercor/bhad162}},
doi = {{10.1093/cercor/bhad162}},
volume = {{33}},
year = {{2023}},
}