Advanced

From the fetal liver to spleen and gut: the highway to natural antibody

Rosado, M. M.; Aranburu, A.; Capolunghi, F.; Giorda, E.; Cascioli, S.; Cenci, F.; Petrini, S.; Miller, Eva LU ; Leanderson, Tomas LU and Bottazzo, G. F., et al. (2009) In Mucosal Immunology 2(4). p.351-361
Abstract
The film of sIgA lining the intestinal epithelium plays a role in the regulation of the commensal microflora and prevention of pathogen invasion. We show that, in the absence of intentional immunization, all sIgA in the gut is produced by B-1a B cells. We also show that B-1a B cells and sIgA derive from lineage-negative precursors found in the fetal liver and located in the spleen after birth. The splenic precursors do not generate B cells of the adaptive immune system in bone marrow, spleen, and lymph nodes, but efficiently replenish the cells producing the natural antibodies. Therefore, B-1a B cells with their splenic progenitors and their progeny of plasma cells fill the same function of the primordial immune system of lower... (More)
The film of sIgA lining the intestinal epithelium plays a role in the regulation of the commensal microflora and prevention of pathogen invasion. We show that, in the absence of intentional immunization, all sIgA in the gut is produced by B-1a B cells. We also show that B-1a B cells and sIgA derive from lineage-negative precursors found in the fetal liver and located in the spleen after birth. The splenic precursors do not generate B cells of the adaptive immune system in bone marrow, spleen, and lymph nodes, but efficiently replenish the cells producing the natural antibodies. Therefore, B-1a B cells with their splenic progenitors and their progeny of plasma cells fill the same function of the primordial immune system of lower vertebrates. The natural antibodies in the serum and on the intestinal epithelium may be an evolutionary ancient tool for the immediate protection against commensal and pathogenic bacteria. (Less)
Please use this url to cite or link to this publication:
author
, et al. (More)
(Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Mucosal Immunology
volume
2
issue
4
pages
351 - 361
publisher
Nature Publishing Group
external identifiers
  • wos:000267055000010
  • scopus:67649277662
ISSN
1933-0219
DOI
10.1038/mi.2009.15
language
English
LU publication?
yes
id
4b43a6ba-4d16-42e4-bb81-a5fe903cbfea (old id 1441586)
date added to LUP
2009-07-28 08:29:18
date last changed
2017-10-01 03:46:01
@article{4b43a6ba-4d16-42e4-bb81-a5fe903cbfea,
  abstract     = {The film of sIgA lining the intestinal epithelium plays a role in the regulation of the commensal microflora and prevention of pathogen invasion. We show that, in the absence of intentional immunization, all sIgA in the gut is produced by B-1a B cells. We also show that B-1a B cells and sIgA derive from lineage-negative precursors found in the fetal liver and located in the spleen after birth. The splenic precursors do not generate B cells of the adaptive immune system in bone marrow, spleen, and lymph nodes, but efficiently replenish the cells producing the natural antibodies. Therefore, B-1a B cells with their splenic progenitors and their progeny of plasma cells fill the same function of the primordial immune system of lower vertebrates. The natural antibodies in the serum and on the intestinal epithelium may be an evolutionary ancient tool for the immediate protection against commensal and pathogenic bacteria.},
  author       = {Rosado, M. M. and Aranburu, A. and Capolunghi, F. and Giorda, E. and Cascioli, S. and Cenci, F. and Petrini, S. and Miller, Eva and Leanderson, Tomas and Bottazzo, G. F. and Natali, P. G. and Carsetti, R.},
  issn         = {1933-0219},
  language     = {eng},
  number       = {4},
  pages        = {351--361},
  publisher    = {Nature Publishing Group},
  series       = {Mucosal Immunology},
  title        = {From the fetal liver to spleen and gut: the highway to natural antibody},
  url          = {http://dx.doi.org/10.1038/mi.2009.15},
  volume       = {2},
  year         = {2009},
}