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Vaccination against atherosclerosis? Induction of atheroprotective immunity

Hansson, Goran K. and Nilsson, Jan LU (2009) In Seminars in Immunopathology2007-01-01+01:00 31(1). p.95-101
Abstract
Atherosclerosis involves the formation of inflammatory arterial lesions and is one of the most common causes of death globally. It has been evident for more than 20 years that adaptive immunity regulates the magnitude of the atherogenic proinflammatory response. T cells may also influence the stability of the atherosclerotic lesion and thus the propensity for thrombus formation and the clinical outcome of disease. Immunization of hypercholesterolemic animals with low-density lipoprotein preparations reduces atherosclerosis, suggesting that vaccination may represent a useful strategy for disease prevention or modulation. This review summarizes our current understanding of the role immunity in atherosclerosis and outlines strategies for... (More)
Atherosclerosis involves the formation of inflammatory arterial lesions and is one of the most common causes of death globally. It has been evident for more than 20 years that adaptive immunity regulates the magnitude of the atherogenic proinflammatory response. T cells may also influence the stability of the atherosclerotic lesion and thus the propensity for thrombus formation and the clinical outcome of disease. Immunization of hypercholesterolemic animals with low-density lipoprotein preparations reduces atherosclerosis, suggesting that vaccination may represent a useful strategy for disease prevention or modulation. This review summarizes our current understanding of the role immunity in atherosclerosis and outlines strategies for antigen-specific prevention of this disease. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Seminars in Immunopathology2007-01-01+01:00
volume
31
issue
1
pages
95 - 101
publisher
Springer
external identifiers
  • wos:000266884000008
  • scopus:67749133396
ISSN
1863-2300
DOI
10.1007/s00281-009-0151-x
language
English
LU publication?
yes
id
14185c23-00e7-4240-b3da-761ed974fa31 (old id 1441866)
date added to LUP
2009-07-27 15:05:09
date last changed
2017-01-01 05:08:00
@article{14185c23-00e7-4240-b3da-761ed974fa31,
  abstract     = {Atherosclerosis involves the formation of inflammatory arterial lesions and is one of the most common causes of death globally. It has been evident for more than 20 years that adaptive immunity regulates the magnitude of the atherogenic proinflammatory response. T cells may also influence the stability of the atherosclerotic lesion and thus the propensity for thrombus formation and the clinical outcome of disease. Immunization of hypercholesterolemic animals with low-density lipoprotein preparations reduces atherosclerosis, suggesting that vaccination may represent a useful strategy for disease prevention or modulation. This review summarizes our current understanding of the role immunity in atherosclerosis and outlines strategies for antigen-specific prevention of this disease.},
  author       = {Hansson, Goran K. and Nilsson, Jan},
  issn         = {1863-2300},
  language     = {eng},
  number       = {1},
  pages        = {95--101},
  publisher    = {Springer},
  series       = {Seminars in Immunopathology2007-01-01+01:00},
  title        = {Vaccination against atherosclerosis? Induction of atheroprotective immunity},
  url          = {http://dx.doi.org/10.1007/s00281-009-0151-x},
  volume       = {31},
  year         = {2009},
}