Advanced

Highly increased familial risks for specific lymphoma subtypes

Goldin, Lynn R.; Bjorkholm, Magnus; Kristinsson, Sigurdur Y.; Turesson, Ingemar LU and Landgren, Ola (2009) In British Journal of Haematology 146(1). p.91-94
Abstract
P>Studies have shown that familial risk contributes to aetiology of lymphomas. Using large population registries from Sweden, we evaluated risk of lymphoma subtypes among first-degree relatives of 2668 follicular lymphoma (FL) patients, 2517 diffuse large B-cell lymphoma (DLBCL) patients, and 6963 Hodgkin lymphoma (HL) patients compared to first-degree relatives of controls. Relatives were at the highest risk for developing the same lymphoma subtype as the case. DLBCL was increased 10-fold among relatives of DLBCL patients, FL was increased fourfold among relatives of FL patients and HL was increased fourfold among relatives of HL patients. These results imply that germline susceptibility genes are specific to lymphoma subtype.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
non-Hodgkin lymphoma, diffuse large B-cell lymphoma, follicular, familial risk, lymphoma, Hodgkin lymphoma
in
British Journal of Haematology
volume
146
issue
1
pages
91 - 94
publisher
Federation of European Neuroscience Societies and Blackwell Publishing Ltd
external identifiers
  • wos:000266921600011
  • scopus:66949164763
ISSN
0007-1048
DOI
10.1111/j.1365-2141.2009.07721.x
language
English
LU publication?
yes
id
6b065690-18df-4d4d-a830-483c1cb043ae (old id 1442361)
date added to LUP
2009-07-24 13:39:27
date last changed
2017-08-13 03:39:16
@article{6b065690-18df-4d4d-a830-483c1cb043ae,
  abstract     = {P>Studies have shown that familial risk contributes to aetiology of lymphomas. Using large population registries from Sweden, we evaluated risk of lymphoma subtypes among first-degree relatives of 2668 follicular lymphoma (FL) patients, 2517 diffuse large B-cell lymphoma (DLBCL) patients, and 6963 Hodgkin lymphoma (HL) patients compared to first-degree relatives of controls. Relatives were at the highest risk for developing the same lymphoma subtype as the case. DLBCL was increased 10-fold among relatives of DLBCL patients, FL was increased fourfold among relatives of FL patients and HL was increased fourfold among relatives of HL patients. These results imply that germline susceptibility genes are specific to lymphoma subtype.},
  author       = {Goldin, Lynn R. and Bjorkholm, Magnus and Kristinsson, Sigurdur Y. and Turesson, Ingemar and Landgren, Ola},
  issn         = {0007-1048},
  keyword      = {non-Hodgkin lymphoma,diffuse large B-cell lymphoma,follicular,familial risk,lymphoma,Hodgkin lymphoma},
  language     = {eng},
  number       = {1},
  pages        = {91--94},
  publisher    = {Federation of European Neuroscience Societies and Blackwell Publishing Ltd},
  series       = {British Journal of Haematology},
  title        = {Highly increased familial risks for specific lymphoma subtypes},
  url          = {http://dx.doi.org/10.1111/j.1365-2141.2009.07721.x},
  volume       = {146},
  year         = {2009},
}