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Immune function and organochlorine pollutants in arctic breeding glaucous gulls

Bustnes, JO; Hanssen, SA; Folstad, I; Erikstad, KE; Hasselquist, Dennis LU and Skaare, JU (2004) In Archives of Environmental Contamination and Toxicology 47(4). p.530-541
Abstract
Organochlorine contaminants (OCs) are known to affect the immune systems of wildlife, and in this study we assessed the relationship between blood concentration of different OCs and measurements relevant to immune status and function in arctic breeding glaucous gulls (Larus hyperboreus). In 1997 and 2001, we counted white blood cells (heterophils and lymphocytes) from blood smears, and in 2000 and 2001 we injected two novel nonpathogenic antigens (diphtheria and tetanus toxoids) into the pectoral muscle of gulls and measured the primary antibody responses. We then related these measurements to the blood concentrations of three pesticides (hexachlorobenzene [HCB], oxychlordane, and p,p'-dichlorodiphenyldichloroethylene) and seven different... (More)
Organochlorine contaminants (OCs) are known to affect the immune systems of wildlife, and in this study we assessed the relationship between blood concentration of different OCs and measurements relevant to immune status and function in arctic breeding glaucous gulls (Larus hyperboreus). In 1997 and 2001, we counted white blood cells (heterophils and lymphocytes) from blood smears, and in 2000 and 2001 we injected two novel nonpathogenic antigens (diphtheria and tetanus toxoids) into the pectoral muscle of gulls and measured the primary antibody responses. We then related these measurements to the blood concentrations of three pesticides (hexachlorobenzene [HCB], oxychlordane, and p,p'-dichlorodiphenyldichloroethylene) and seven different polychlorinated biphenyl congeners (PCB 101, 99, 118, 153, 138, 180, and 170). There were significant or near significant positive relationships (0.1 > p > 0.001) between most persistent OCs and the levels of heterophils in the blood for both sexes in 1997 and for male gulls in 2001. Similarly, levels of all persistent OCs and lymphocytes were positively related (0.1 > p > 0.001) in both sexes in 1997. This suggests that OCs are causing alterations to immune systems, which may decrease their efficiency and make the birds more susceptible to parasites and diseases. In female gulls, the antibody response to the diphtheria toxoid was significant and negative for HCB (p <0.01) and weaker, but significant, for oxychlordane (p <0.05), suggesting that OCs were causing an impairment of the humoral immunity. Various OCs have been linked to negative effects in our study population, including decreased survival and reproduction, and this study suggests that such compounds also affect immune status and function. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Archives of Environmental Contamination and Toxicology
volume
47
issue
4
pages
530 - 541
publisher
Springer
external identifiers
  • pmid:15499504
  • wos:000224753800013
  • scopus:7944235838
ISSN
0090-4341
DOI
10.1007/s00244-003-3203-6
language
English
LU publication?
yes
id
ef0228cf-0266-4f9d-9f76-0ead28175363 (old id 145180)
date added to LUP
2007-06-25 13:09:43
date last changed
2017-07-02 03:31:30
@article{ef0228cf-0266-4f9d-9f76-0ead28175363,
  abstract     = {Organochlorine contaminants (OCs) are known to affect the immune systems of wildlife, and in this study we assessed the relationship between blood concentration of different OCs and measurements relevant to immune status and function in arctic breeding glaucous gulls (Larus hyperboreus). In 1997 and 2001, we counted white blood cells (heterophils and lymphocytes) from blood smears, and in 2000 and 2001 we injected two novel nonpathogenic antigens (diphtheria and tetanus toxoids) into the pectoral muscle of gulls and measured the primary antibody responses. We then related these measurements to the blood concentrations of three pesticides (hexachlorobenzene [HCB], oxychlordane, and p,p'-dichlorodiphenyldichloroethylene) and seven different polychlorinated biphenyl congeners (PCB 101, 99, 118, 153, 138, 180, and 170). There were significant or near significant positive relationships (0.1 &gt; p &gt; 0.001) between most persistent OCs and the levels of heterophils in the blood for both sexes in 1997 and for male gulls in 2001. Similarly, levels of all persistent OCs and lymphocytes were positively related (0.1 &gt; p &gt; 0.001) in both sexes in 1997. This suggests that OCs are causing alterations to immune systems, which may decrease their efficiency and make the birds more susceptible to parasites and diseases. In female gulls, the antibody response to the diphtheria toxoid was significant and negative for HCB (p &lt;0.01) and weaker, but significant, for oxychlordane (p &lt;0.05), suggesting that OCs were causing an impairment of the humoral immunity. Various OCs have been linked to negative effects in our study population, including decreased survival and reproduction, and this study suggests that such compounds also affect immune status and function.},
  author       = {Bustnes, JO and Hanssen, SA and Folstad, I and Erikstad, KE and Hasselquist, Dennis and Skaare, JU},
  issn         = {0090-4341},
  language     = {eng},
  number       = {4},
  pages        = {530--541},
  publisher    = {Springer},
  series       = {Archives of Environmental Contamination and Toxicology},
  title        = {Immune function and organochlorine pollutants in arctic breeding glaucous gulls},
  url          = {http://dx.doi.org/10.1007/s00244-003-3203-6},
  volume       = {47},
  year         = {2004},
}