The contact/kinin and complement systems in vasculitis.
Karpman, Diana LU
and Kahn, Robin
LU
(2009)
In APMIS Acta Pathologica, Microbiologica et Immunologica Scandinavica. Supplementum
117.
p.48-54
- Abstract
- Vasculitides are a group of conditions with marked inflammation in and around vessel walls and vascular leakage. These conditions may involve the presence of auto-antibodies such as ANCA or may be mediated by other autoimmune or pathogenic mechanisms. Regardless of the primary trigger, vasculitides entail activation of the complement system as well as the contact/kinin system. In vivo and in vitro data support the involvement of these systems showing activation of the alternative, classical and lectin complement pathways as well as release of bradykinin at sites of vascular inflammation. This short review will summarize some of the data regarding the participation of these systems and the interplay between the complement and kinin systems... (More)
- Vasculitides are a group of conditions with marked inflammation in and around vessel walls and vascular leakage. These conditions may involve the presence of auto-antibodies such as ANCA or may be mediated by other autoimmune or pathogenic mechanisms. Regardless of the primary trigger, vasculitides entail activation of the complement system as well as the contact/kinin system. In vivo and in vitro data support the involvement of these systems showing activation of the alternative, classical and lectin complement pathways as well as release of bradykinin at sites of vascular inflammation. This short review will summarize some of the data regarding the participation of these systems and the interplay between the complement and kinin systems as well as their interaction with the endothelium and neutrophils. Although these systems do not play a primary role in induction of vasculitis, the peptides released contribute to inflammation and vascular leakage and may thus be identified as potential therapeutic targets. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1452722
- author
- Karpman, Diana
LU
and Kahn, Robin
LU
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- in
- APMIS Acta Pathologica, Microbiologica et Immunologica Scandinavica. Supplementum
- volume
- 117
- pages
- 48 - 54
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000268183700009
- pmid:19515140
- scopus:66949161955
- pmid:19515140
- ISSN
- 0903-465X
- DOI
- 10.1111/j.1600-0463.2009.02477.x
- language
- English
- LU publication?
- yes
- id
- ac0e944b-ff9c-4bbd-a517-ff594727f759 (old id 1452722)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/19515140?dopt=Abstract
- date added to LUP
- 2016-04-04 09:15:29
- date last changed
- 2022-01-29 17:00:43
@article{ac0e944b-ff9c-4bbd-a517-ff594727f759,
abstract = {{Vasculitides are a group of conditions with marked inflammation in and around vessel walls and vascular leakage. These conditions may involve the presence of auto-antibodies such as ANCA or may be mediated by other autoimmune or pathogenic mechanisms. Regardless of the primary trigger, vasculitides entail activation of the complement system as well as the contact/kinin system. In vivo and in vitro data support the involvement of these systems showing activation of the alternative, classical and lectin complement pathways as well as release of bradykinin at sites of vascular inflammation. This short review will summarize some of the data regarding the participation of these systems and the interplay between the complement and kinin systems as well as their interaction with the endothelium and neutrophils. Although these systems do not play a primary role in induction of vasculitis, the peptides released contribute to inflammation and vascular leakage and may thus be identified as potential therapeutic targets.}},
author = {{Karpman, Diana and Kahn, Robin}},
issn = {{0903-465X}},
language = {{eng}},
pages = {{48--54}},
publisher = {{Wiley-Blackwell}},
series = {{APMIS Acta Pathologica, Microbiologica et Immunologica Scandinavica. Supplementum}},
title = {{The contact/kinin and complement systems in vasculitis.}},
url = {{http://dx.doi.org/10.1111/j.1600-0463.2009.02477.x}},
doi = {{10.1111/j.1600-0463.2009.02477.x}},
volume = {{117}},
year = {{2009}},
}