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Clinical Manifestations and Epidemiology of the New Genetic Variant of Chlamydia trachomatis.

Bjartling, Carina LU ; Osser, Stellan LU ; Johnsson, Annika LU and Persson, Kenneth LU (2009) In Sexually Transmitted Diseases 36. p.529-535
Abstract
BACKGROUND:: In 2006, a new genetic variant of Chlamydia trachomatis (nvCT) was discovered in Sweden. Clinical manifestations of this infection were studied in a high-risk population. METHODS:: During 2007, a prospective case-control study on sexual lifestyle and urogenital infections was performed at the Centre for Sexual Health (CSH), affiliated to Malmo University Hospital. A total of 629 C. trachomatis positive cases and 1252 negative controls were included. At Malmo University Hospital, Department of Obstetrics and Gynecology, all cases of pelvic inflammatory disease (PID) were assessed and correlated to the prevalence of nvCT. RESULTS:: Patients with nvCT or wild type C. trachomatis (wtCT) infection did not differ regarding their... (More)
BACKGROUND:: In 2006, a new genetic variant of Chlamydia trachomatis (nvCT) was discovered in Sweden. Clinical manifestations of this infection were studied in a high-risk population. METHODS:: During 2007, a prospective case-control study on sexual lifestyle and urogenital infections was performed at the Centre for Sexual Health (CSH), affiliated to Malmo University Hospital. A total of 629 C. trachomatis positive cases and 1252 negative controls were included. At Malmo University Hospital, Department of Obstetrics and Gynecology, all cases of pelvic inflammatory disease (PID) were assessed and correlated to the prevalence of nvCT. RESULTS:: Patients with nvCT or wild type C. trachomatis (wtCT) infection did not differ regarding their sexual lifestyle. Men with nvCT or wtCT infection did not differ in uro-genital symptoms or clinical findings. Women with nvCT infection reported painful urination (12.2% vs. 25.8%, P = 0.02) and were diagnosed with urethritis (11.1% vs. 40.0%, P = 0.04) less often than women with wtCT infection. The ratio of lower abdominal pain in women with nvCT infection was only half of that in women with wtCT infection (13.4% vs. 27.8%, P = 0.02). PID was detected in 0.8% of women with C. trachomatis infection in Malmo. All these cases were due to wtCT infection. CONCLUSIONS:: Symptomatic urethral infection and lower abdominal pain was less common in women with nvCT as compared to wtCT. Infection with nvCT was more frequently asymptomatic suggesting a possible difference in virulence between the nvCT strain and the wtCT strain. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Sexually Transmitted Diseases
volume
36
pages
529 - 535
publisher
Lippincott Williams & Wilkins
external identifiers
  • wos:000269374100001
  • pmid:19617866
  • scopus:70349329734
ISSN
1537-4521
DOI
10.1097/OLQ.0b013e3181a8cef1
language
English
LU publication?
yes
id
be66a972-be1d-4e92-9a17-bd1270edf8cb (old id 1452960)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19617866?dopt=Abstract
date added to LUP
2009-08-04 11:57:29
date last changed
2017-01-01 07:53:59
@article{be66a972-be1d-4e92-9a17-bd1270edf8cb,
  abstract     = {BACKGROUND:: In 2006, a new genetic variant of Chlamydia trachomatis (nvCT) was discovered in Sweden. Clinical manifestations of this infection were studied in a high-risk population. METHODS:: During 2007, a prospective case-control study on sexual lifestyle and urogenital infections was performed at the Centre for Sexual Health (CSH), affiliated to Malmo University Hospital. A total of 629 C. trachomatis positive cases and 1252 negative controls were included. At Malmo University Hospital, Department of Obstetrics and Gynecology, all cases of pelvic inflammatory disease (PID) were assessed and correlated to the prevalence of nvCT. RESULTS:: Patients with nvCT or wild type C. trachomatis (wtCT) infection did not differ regarding their sexual lifestyle. Men with nvCT or wtCT infection did not differ in uro-genital symptoms or clinical findings. Women with nvCT infection reported painful urination (12.2% vs. 25.8%, P = 0.02) and were diagnosed with urethritis (11.1% vs. 40.0%, P = 0.04) less often than women with wtCT infection. The ratio of lower abdominal pain in women with nvCT infection was only half of that in women with wtCT infection (13.4% vs. 27.8%, P = 0.02). PID was detected in 0.8% of women with C. trachomatis infection in Malmo. All these cases were due to wtCT infection. CONCLUSIONS:: Symptomatic urethral infection and lower abdominal pain was less common in women with nvCT as compared to wtCT. Infection with nvCT was more frequently asymptomatic suggesting a possible difference in virulence between the nvCT strain and the wtCT strain.},
  author       = {Bjartling, Carina and Osser, Stellan and Johnsson, Annika and Persson, Kenneth},
  issn         = {1537-4521},
  language     = {eng},
  pages        = {529--535},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Sexually Transmitted Diseases},
  title        = {Clinical Manifestations and Epidemiology of the New Genetic Variant of Chlamydia trachomatis.},
  url          = {http://dx.doi.org/10.1097/OLQ.0b013e3181a8cef1},
  volume       = {36},
  year         = {2009},
}