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The Effect of Postadded Ethylene Glycol Surfactants on DNA-Cationic Surfactant/Water Mesophases.

Leal, Cecilia LU ; Bilalov, Azat LU and Lindman, Björn LU (2009) In The Journal of Physical Chemistry Part B 113(29). p.9909-9914
Abstract
The addition of amphiphiles grafted with polyethylene glycol units to constructs of DNA-amphiphiles is of most relevance for applications demanding colloidal stability. In this work, we study the self-assembly behavior of a true ternary mixture comprising (i) an electroneutral complex of DNA and a cationic surfactant (dodecyltrimethylammonium, DTA), (ii) water, and (iii) nonionic surfactant (dodecyl tetraethylene glycol, C(12)EO(4); and dodecyl octaethylene glycol, C(12)EO(8)). The phase diagrams of the two systems: DNA-DTA/C(12)EO(4)/water and DNA-DTA/C(12)EO(8)/water were carried out using (2)H NMR, and small-angle X-ray scattering (SAXS). In both mixtures, the DNA-DTA complex incorporates the postadded nonionic surfactant and large... (More)
The addition of amphiphiles grafted with polyethylene glycol units to constructs of DNA-amphiphiles is of most relevance for applications demanding colloidal stability. In this work, we study the self-assembly behavior of a true ternary mixture comprising (i) an electroneutral complex of DNA and a cationic surfactant (dodecyltrimethylammonium, DTA), (ii) water, and (iii) nonionic surfactant (dodecyl tetraethylene glycol, C(12)EO(4); and dodecyl octaethylene glycol, C(12)EO(8)). The phase diagrams of the two systems: DNA-DTA/C(12)EO(4)/water and DNA-DTA/C(12)EO(8)/water were carried out using (2)H NMR, and small-angle X-ray scattering (SAXS). In both mixtures, the DNA-DTA complex incorporates the postadded nonionic surfactant and large liquid crystalline regions were found. The supramolecular assemblies evolve from a 2D hexagonal structure of the normal type to a lamellar phase as the content of nonionic surfactant is increased. The effect of ethylene glycol unit size in the phase behavior is discussed. We suggest that when longer ethylene glycol units (C(12)EO(8) vs C(12)EO(4)) are used, the DNA-DTA aggregate gets saturated with the nonionic surfactant and there exists a coexistence of a fully swollen mesophase phase of C(12)EO(8) alone presumably of the normal hexagonal type with the lamellar and hexagonal phases of DNA-DTA/C(12)EO(8)/water. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
The Journal of Physical Chemistry Part B
volume
113
issue
29
pages
9909 - 9914
publisher
The American Chemical Society
external identifiers
  • wos:000268139600036
  • pmid:19603840
  • scopus:67650819119
ISSN
1520-5207
DOI
10.1021/jp810185k
language
English
LU publication?
yes
id
cb7fdbdf-f38a-4c25-b7b3-022384337ced (old id 1453075)
date added to LUP
2009-09-01 08:40:09
date last changed
2017-09-24 04:05:02
@article{cb7fdbdf-f38a-4c25-b7b3-022384337ced,
  abstract     = {The addition of amphiphiles grafted with polyethylene glycol units to constructs of DNA-amphiphiles is of most relevance for applications demanding colloidal stability. In this work, we study the self-assembly behavior of a true ternary mixture comprising (i) an electroneutral complex of DNA and a cationic surfactant (dodecyltrimethylammonium, DTA), (ii) water, and (iii) nonionic surfactant (dodecyl tetraethylene glycol, C(12)EO(4); and dodecyl octaethylene glycol, C(12)EO(8)). The phase diagrams of the two systems: DNA-DTA/C(12)EO(4)/water and DNA-DTA/C(12)EO(8)/water were carried out using (2)H NMR, and small-angle X-ray scattering (SAXS). In both mixtures, the DNA-DTA complex incorporates the postadded nonionic surfactant and large liquid crystalline regions were found. The supramolecular assemblies evolve from a 2D hexagonal structure of the normal type to a lamellar phase as the content of nonionic surfactant is increased. The effect of ethylene glycol unit size in the phase behavior is discussed. We suggest that when longer ethylene glycol units (C(12)EO(8) vs C(12)EO(4)) are used, the DNA-DTA aggregate gets saturated with the nonionic surfactant and there exists a coexistence of a fully swollen mesophase phase of C(12)EO(8) alone presumably of the normal hexagonal type with the lamellar and hexagonal phases of DNA-DTA/C(12)EO(8)/water.},
  author       = {Leal, Cecilia and Bilalov, Azat and Lindman, Björn},
  issn         = {1520-5207},
  language     = {eng},
  number       = {29},
  pages        = {9909--9914},
  publisher    = {The American Chemical Society},
  series       = {The Journal of Physical Chemistry Part B},
  title        = {The Effect of Postadded Ethylene Glycol Surfactants on DNA-Cationic Surfactant/Water Mesophases.},
  url          = {http://dx.doi.org/10.1021/jp810185k},
  volume       = {113},
  year         = {2009},
}