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Association between plasma homocysteine levels and mortality in elderly patients with mental illness.

Nilsson, Karin LU ; Gustafson, Lars LU and Hultberg, Björn LU (2009) In Dementia and Geriatric Cognitive Disorders 27(6). p.579-583
Abstract
BACKGROUND/METHOD: Total plasma homocysteine (tHcy) concentration is elevated in elderly patients with mental illness. Plasma tHcy is known to be associated with cardiovascular disease, renal impairment and negative lifestyle factors, and has been shown to predict mortality in human subjects. Epidemiological data on this topic in elderly patients with mental illness are missing. We therefore investigated the association between plasma tHcy levels and mortality in these patients. RESULTS: The group of deceased patients showed higher age, higher plasma tHcy, lower renal function and lower serum folate than patients who were still alive. Only age, plasma tHcy and the presence of vascular disease significantly influenced mortality. CONCLUSION:... (More)
BACKGROUND/METHOD: Total plasma homocysteine (tHcy) concentration is elevated in elderly patients with mental illness. Plasma tHcy is known to be associated with cardiovascular disease, renal impairment and negative lifestyle factors, and has been shown to predict mortality in human subjects. Epidemiological data on this topic in elderly patients with mental illness are missing. We therefore investigated the association between plasma tHcy levels and mortality in these patients. RESULTS: The group of deceased patients showed higher age, higher plasma tHcy, lower renal function and lower serum folate than patients who were still alive. Only age, plasma tHcy and the presence of vascular disease significantly influenced mortality. CONCLUSION: The association between plasma tHcy level and mortality risk was probably explained in part by the two plasma tHcy determinants age and presence of vascular disease. The determination of plasma tHcy in elderly patients with mental illness may help to identify patients in need of more intensive treatment. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Dementia and Geriatric Cognitive Disorders
volume
27
issue
6
pages
579 - 583
publisher
Karger
external identifiers
  • wos:000269160500013
  • pmid:19602886
  • scopus:67650099739
ISSN
1420-8008
DOI
10.1159/000228260
language
English
LU publication?
yes
id
1974375c-ed71-4008-a48d-06a6b880ca02 (old id 1453081)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19602886?dopt=Abstract
date added to LUP
2009-08-04 11:24:41
date last changed
2017-01-01 07:32:41
@article{1974375c-ed71-4008-a48d-06a6b880ca02,
  abstract     = {BACKGROUND/METHOD: Total plasma homocysteine (tHcy) concentration is elevated in elderly patients with mental illness. Plasma tHcy is known to be associated with cardiovascular disease, renal impairment and negative lifestyle factors, and has been shown to predict mortality in human subjects. Epidemiological data on this topic in elderly patients with mental illness are missing. We therefore investigated the association between plasma tHcy levels and mortality in these patients. RESULTS: The group of deceased patients showed higher age, higher plasma tHcy, lower renal function and lower serum folate than patients who were still alive. Only age, plasma tHcy and the presence of vascular disease significantly influenced mortality. CONCLUSION: The association between plasma tHcy level and mortality risk was probably explained in part by the two plasma tHcy determinants age and presence of vascular disease. The determination of plasma tHcy in elderly patients with mental illness may help to identify patients in need of more intensive treatment.},
  author       = {Nilsson, Karin and Gustafson, Lars and Hultberg, Björn},
  issn         = {1420-8008},
  language     = {eng},
  number       = {6},
  pages        = {579--583},
  publisher    = {Karger},
  series       = {Dementia and Geriatric Cognitive Disorders},
  title        = {Association between plasma homocysteine levels and mortality in elderly patients with mental illness.},
  url          = {http://dx.doi.org/10.1159/000228260},
  volume       = {27},
  year         = {2009},
}