Thiopental pharmacokinetics in newborn infants: a case report of overdose.
Norman, Elisabeth LU ; Malmqvist, Ulf LU ; Westrin, Per LU and Fellman, Vineta LU
(2009)
In Acta paediatrica
98.
p.1680-1682
- Abstract
- Abstract Thiopental may be used for sedation before intubation in newborn infants. A boy, born at 33 weeks of gestation (gw); birth weight 2435 g, was prescribed thiopental 3 mg/kg before intubation. He developed temporary hypotension and oxygen desaturation, and remained unconscious for longer than expected with a suppressed electroencephalography for 48 h. Serum thiopental concentration was 82, 59, 42 and 32 mumol/L after 20 min and 6, 24 and 68 h respectively. Serum concentrations from five newborn infants at the same time points after intubation with the same thiopental dose were used as reference values, and indicated a 10-fold overdose in the index case. The cause of the overdose could not be identified. The infant recovered;... (More)
- Abstract Thiopental may be used for sedation before intubation in newborn infants. A boy, born at 33 weeks of gestation (gw); birth weight 2435 g, was prescribed thiopental 3 mg/kg before intubation. He developed temporary hypotension and oxygen desaturation, and remained unconscious for longer than expected with a suppressed electroencephalography for 48 h. Serum thiopental concentration was 82, 59, 42 and 32 mumol/L after 20 min and 6, 24 and 68 h respectively. Serum concentrations from five newborn infants at the same time points after intubation with the same thiopental dose were used as reference values, and indicated a 10-fold overdose in the index case. The cause of the overdose could not be identified. The infant recovered; cerebral magnetic resonance imaging at the age of 42 gw and psychomotor development at 2 years were normal. These results show that thiopental concentrations are variable in neonates and there is a high risk of dosage error as no specific paediatric formulation is available. Conclusion: Well-designed procedures and continuous education are required to prevent errors and adverse events during drug delivery to newborn infants. To develop a safe method of administration for thiopental, an extended pharmacokinetic and pharmacodynamic study in neonates is warranted. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1453324
- author
- Norman, Elisabeth
LU
; Malmqvist, Ulf
LU
; Westrin, Per
LU
and Fellman, Vineta
LU
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Acta paediatrica
- volume
- 98
- pages
- 1680 - 1682
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000269491100029
- pmid:19583708
- scopus:69749119542
- pmid:19583708
- ISSN
- 1651-2227
- DOI
- 10.1111/j.1651-2227.2009.01394.x
- language
- English
- LU publication?
- yes
- id
- 704b00e4-e211-4116-821d-e1ef3b19ed7d (old id 1453324)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/19583708?dopt=Abstract
- date added to LUP
- 2016-04-04 09:06:04
- date last changed
- 2022-01-29 08:17:24
@article{704b00e4-e211-4116-821d-e1ef3b19ed7d,
abstract = {{Abstract Thiopental may be used for sedation before intubation in newborn infants. A boy, born at 33 weeks of gestation (gw); birth weight 2435 g, was prescribed thiopental 3 mg/kg before intubation. He developed temporary hypotension and oxygen desaturation, and remained unconscious for longer than expected with a suppressed electroencephalography for 48 h. Serum thiopental concentration was 82, 59, 42 and 32 mumol/L after 20 min and 6, 24 and 68 h respectively. Serum concentrations from five newborn infants at the same time points after intubation with the same thiopental dose were used as reference values, and indicated a 10-fold overdose in the index case. The cause of the overdose could not be identified. The infant recovered; cerebral magnetic resonance imaging at the age of 42 gw and psychomotor development at 2 years were normal. These results show that thiopental concentrations are variable in neonates and there is a high risk of dosage error as no specific paediatric formulation is available. Conclusion: Well-designed procedures and continuous education are required to prevent errors and adverse events during drug delivery to newborn infants. To develop a safe method of administration for thiopental, an extended pharmacokinetic and pharmacodynamic study in neonates is warranted.}},
author = {{Norman, Elisabeth and Malmqvist, Ulf and Westrin, Per and Fellman, Vineta}},
issn = {{1651-2227}},
language = {{eng}},
pages = {{1680--1682}},
publisher = {{Wiley-Blackwell}},
series = {{Acta paediatrica}},
title = {{Thiopental pharmacokinetics in newborn infants: a case report of overdose.}},
url = {{http://dx.doi.org/10.1111/j.1651-2227.2009.01394.x}},
doi = {{10.1111/j.1651-2227.2009.01394.x}},
volume = {{98}},
year = {{2009}},
}