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Enhanced Protein Steering: Cooperative Electrostatic and van der Waals Forces in Antigen-Antibody Complexes.

Persson, Björn LU ; Jönsson, Bo LU and Lund, Mikael LU (2009) In The Journal of Physical Chemistry Part B 113(30). p.10459-10464
Abstract
We study the association of the cationic protein lysozyme with several almost neutral protein fragments but with highly uneven charge distributions. Using mesoscopic protein models, we show how electrostatic interactions can align or steer protein complexes into specific constellations dictated by the specific charge distributions of the interacting biomolecules. Including van der Waals forces significantly amplifies the electrostatically induced orientational steering at physiological solution conditions, demonstrating that different intermolecular interactions can work in a cooperative way in order to optimize specific biochemical mechanisms. Individually, the electrostatic and van der Waals interactions lead only to a relatively weak... (More)
We study the association of the cationic protein lysozyme with several almost neutral protein fragments but with highly uneven charge distributions. Using mesoscopic protein models, we show how electrostatic interactions can align or steer protein complexes into specific constellations dictated by the specific charge distributions of the interacting biomolecules. Including van der Waals forces significantly amplifies the electrostatically induced orientational steering at physiological solution conditions, demonstrating that different intermolecular interactions can work in a cooperative way in order to optimize specific biochemical mechanisms. Individually, the electrostatic and van der Waals interactions lead only to a relatively weak intermolecular alignment, but when combined, the effect increases significantly. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
The Journal of Physical Chemistry Part B
volume
113
issue
30
pages
10459 - 10464
publisher
The American Chemical Society
external identifiers
  • wos:000268231000055
  • pmid:19583233
  • scopus:67651207529
ISSN
1520-5207
DOI
10.1021/jp904541g
language
English
LU publication?
yes
id
e63ebffd-f91a-4532-8a3b-45d93c0746bf (old id 1453337)
date added to LUP
2009-09-01 08:35:48
date last changed
2017-07-23 04:05:54
@article{e63ebffd-f91a-4532-8a3b-45d93c0746bf,
  abstract     = {We study the association of the cationic protein lysozyme with several almost neutral protein fragments but with highly uneven charge distributions. Using mesoscopic protein models, we show how electrostatic interactions can align or steer protein complexes into specific constellations dictated by the specific charge distributions of the interacting biomolecules. Including van der Waals forces significantly amplifies the electrostatically induced orientational steering at physiological solution conditions, demonstrating that different intermolecular interactions can work in a cooperative way in order to optimize specific biochemical mechanisms. Individually, the electrostatic and van der Waals interactions lead only to a relatively weak intermolecular alignment, but when combined, the effect increases significantly.},
  author       = {Persson, Björn and Jönsson, Bo and Lund, Mikael},
  issn         = {1520-5207},
  language     = {eng},
  number       = {30},
  pages        = {10459--10464},
  publisher    = {The American Chemical Society},
  series       = {The Journal of Physical Chemistry Part B},
  title        = {Enhanced Protein Steering: Cooperative Electrostatic and van der Waals Forces in Antigen-Antibody Complexes.},
  url          = {http://dx.doi.org/10.1021/jp904541g},
  volume       = {113},
  year         = {2009},
}