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Circulatory recovery is as fast with air ventilation as with 100% oxygen after asphyxia-induced cardiac arrest in piglets.

Linnér, Rikard LU ; Werner, Olof LU ; Perez de Sá, Valéria LU and Cunha Goncalves, Doris LU (2009) In Pediatric Research 66. p.391-394
Abstract
We investigated return of spontaneous circulation and of cerebral oxygenation after asphyxia-induced cardiac arrest, using ventilation with air, throughout, or with 100% oxygen for a shorter or longer period. Arterial pressure, heart rate, regional cerebral oxygen saturation (CrSO2) and brain tissue oxygen tension (PbtO2) were measured in one day old piglets that were hypoventilated with air and left in apnea until cardiac arrest. They were randomly assigned to be resuscitated with air (n=13), or with oxygen for 3 (n=12) or 30 min (n = 13) and then with air. Nine, 10, and 10 animals, respectively, needed closed chest cardiac massage. One, none, and 1, respectively, died. Median (quartile range) times from start of ventilation until heart... (More)
We investigated return of spontaneous circulation and of cerebral oxygenation after asphyxia-induced cardiac arrest, using ventilation with air, throughout, or with 100% oxygen for a shorter or longer period. Arterial pressure, heart rate, regional cerebral oxygen saturation (CrSO2) and brain tissue oxygen tension (PbtO2) were measured in one day old piglets that were hypoventilated with air and left in apnea until cardiac arrest. They were randomly assigned to be resuscitated with air (n=13), or with oxygen for 3 (n=12) or 30 min (n = 13) and then with air. Nine, 10, and 10 animals, respectively, needed closed chest cardiac massage. One, none, and 1, respectively, died. Median (quartile range) times from start of ventilation until heart rate reached 150 bpm were 67 (60-76), 88 (76-126), and 68 (56-81) s. They were not significantly different, nor were the arterial pressure responses, times until CrSO2 reached 30%, or times until PbtO2 had increased by 0.1 kPa from its nadir. Peak PbtO2 values during resuscitation were 4.2 (3.3-5.4), 12 (6.4 - 15), and 25 (15 - 36) kPa. Thus, pure oxygen did not accelerate the recovery of circulation or of cerebral oxygenation, while even a brief exposure caused cerebral hyperoxia. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Pediatric Research
volume
66
pages
391 - 394
publisher
International Pediatric Foundation Inc.
external identifiers
  • wos:000270285400007
  • pmid:19581834
  • scopus:70350442811
ISSN
1530-0447
DOI
10.1203/PDR.0b013e3181b3b110
language
English
LU publication?
yes
id
56f757fd-ca9c-4bcd-88e9-e248d6f3bdf7 (old id 1453356)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19581834?dopt=Abstract
date added to LUP
2009-08-04 10:18:38
date last changed
2017-11-19 04:18:01
@article{56f757fd-ca9c-4bcd-88e9-e248d6f3bdf7,
  abstract     = {We investigated return of spontaneous circulation and of cerebral oxygenation after asphyxia-induced cardiac arrest, using ventilation with air, throughout, or with 100% oxygen for a shorter or longer period. Arterial pressure, heart rate, regional cerebral oxygen saturation (CrSO2) and brain tissue oxygen tension (PbtO2) were measured in one day old piglets that were hypoventilated with air and left in apnea until cardiac arrest. They were randomly assigned to be resuscitated with air (n=13), or with oxygen for 3 (n=12) or 30 min (n = 13) and then with air. Nine, 10, and 10 animals, respectively, needed closed chest cardiac massage. One, none, and 1, respectively, died. Median (quartile range) times from start of ventilation until heart rate reached 150 bpm were 67 (60-76), 88 (76-126), and 68 (56-81) s. They were not significantly different, nor were the arterial pressure responses, times until CrSO2 reached 30%, or times until PbtO2 had increased by 0.1 kPa from its nadir. Peak PbtO2 values during resuscitation were 4.2 (3.3-5.4), 12 (6.4 - 15), and 25 (15 - 36) kPa. Thus, pure oxygen did not accelerate the recovery of circulation or of cerebral oxygenation, while even a brief exposure caused cerebral hyperoxia.},
  author       = {Linnér, Rikard and Werner, Olof and Perez de Sá, Valéria and Cunha Goncalves, Doris},
  issn         = {1530-0447},
  language     = {eng},
  pages        = {391--394},
  publisher    = {International Pediatric Foundation Inc.},
  series       = {Pediatric Research},
  title        = {Circulatory recovery is as fast with air ventilation as with 100% oxygen after asphyxia-induced cardiac arrest in piglets.},
  url          = {http://dx.doi.org/10.1203/PDR.0b013e3181b3b110},
  volume       = {66},
  year         = {2009},
}