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Serological testing in small vessel vasculitis

Segelmark, Mårten LU (2020) In Rheumatology (Oxford, England) 59(3). p.51-54
Abstract

Serological analysis has a central role in the diagnostic work-up of patients with suspected small vessel vasculitis, both for establishing a specific diagnosis and for the monitoring of response to therapy. Autoantibodies can be detected in all forms of primary small vessel vasculitis as well as in the most common forms of secondary vasculitis. For primary vasculitis the most important serological test is for ANCA. ANCA can be found in 75-95% of patients with pauci-immune small vessel vasculitis leading to this subgroup of vasculitides being named ANCA associated vasculitis. ANCA levels often follow this disease course, but the value of serial ANCA testing is controversial. Other important autoantibodies in primary small vessel... (More)

Serological analysis has a central role in the diagnostic work-up of patients with suspected small vessel vasculitis, both for establishing a specific diagnosis and for the monitoring of response to therapy. Autoantibodies can be detected in all forms of primary small vessel vasculitis as well as in the most common forms of secondary vasculitis. For primary vasculitis the most important serological test is for ANCA. ANCA can be found in 75-95% of patients with pauci-immune small vessel vasculitis leading to this subgroup of vasculitides being named ANCA associated vasculitis. ANCA levels often follow this disease course, but the value of serial ANCA testing is controversial. Other important autoantibodies in primary small vessel vasculitis are anti-glomerular basement membrane antibodies, anti-C1q, anti-galactose deficient IgA and cryoglobulins. A wide variety of systemic inflammatory diseases and infections can be complicated by small vessel vasculitis and detected by serological testing. Important examples are SLE, rheumatoid arthritis, Hepatitis C and HIV.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
ANCA, autoantibodies, complement, cryoglobulins, vasculitis
in
Rheumatology (Oxford, England)
volume
59
issue
3
pages
4 pages
publisher
Oxford University Press
external identifiers
  • pmid:32348521
  • scopus:85084169307
ISSN
1462-0332
DOI
10.1093/rheumatology/kez633
language
English
LU publication?
yes
id
14549df5-d3f7-43da-8aa5-322b5894cae2
date added to LUP
2020-06-09 13:31:27
date last changed
2020-06-10 06:30:42
@article{14549df5-d3f7-43da-8aa5-322b5894cae2,
  abstract     = {<p>Serological analysis has a central role in the diagnostic work-up of patients with suspected small vessel vasculitis, both for establishing a specific diagnosis and for the monitoring of response to therapy. Autoantibodies can be detected in all forms of primary small vessel vasculitis as well as in the most common forms of secondary vasculitis. For primary vasculitis the most important serological test is for ANCA. ANCA can be found in 75-95% of patients with pauci-immune small vessel vasculitis leading to this subgroup of vasculitides being named ANCA associated vasculitis. ANCA levels often follow this disease course, but the value of serial ANCA testing is controversial. Other important autoantibodies in primary small vessel vasculitis are anti-glomerular basement membrane antibodies, anti-C1q, anti-galactose deficient IgA and cryoglobulins. A wide variety of systemic inflammatory diseases and infections can be complicated by small vessel vasculitis and detected by serological testing. Important examples are SLE, rheumatoid arthritis, Hepatitis C and HIV.</p>},
  author       = {Segelmark, Mårten},
  issn         = {1462-0332},
  language     = {eng},
  month        = {05},
  number       = {3},
  pages        = {51--54},
  publisher    = {Oxford University Press},
  series       = {Rheumatology (Oxford, England)},
  title        = {Serological testing in small vessel vasculitis},
  url          = {http://dx.doi.org/10.1093/rheumatology/kez633},
  doi          = {10.1093/rheumatology/kez633},
  volume       = {59},
  year         = {2020},
}