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Basal metabolic rate and the evolution of the adaptive immune system

Råberg, Lars LU ; Vestberg, Mikael LU ; Hasselquist, Dennis LU ; Holmdahl, Rikard LU ; Svensson, Erik LU and Nilsson, Jan-Åke LU (2002) In Royal Society of London. Proceedings B. Biological Sciences 269(1493). p.817-821
Abstract
Vertebrates have evolved an adaptive immune system in addition to the ancestral innate immune system. It is often assumed that a trade-off between costs and benefits of defence governs the evolution of immunological defence, but the costs and benefits specific to the adaptive immune system are poorly known. We used genetically engineered mice lacking lymphocytes (i.e. mice without adaptive, but with innate, immunity) as a model of the ancestral state in the evolution of the vertebrate immune system. To investigate if the magnitude of adaptive defence is constrained by the energetic costs of producing lymphocytes etc., we compared the basal metabolic rate of normal and lymphocyte-deficient mice. We found that lymphocyte-deficient mice had a... (More)
Vertebrates have evolved an adaptive immune system in addition to the ancestral innate immune system. It is often assumed that a trade-off between costs and benefits of defence governs the evolution of immunological defence, but the costs and benefits specific to the adaptive immune system are poorly known. We used genetically engineered mice lacking lymphocytes (i.e. mice without adaptive, but with innate, immunity) as a model of the ancestral state in the evolution of the vertebrate immune system. To investigate if the magnitude of adaptive defence is constrained by the energetic costs of producing lymphocytes etc., we compared the basal metabolic rate of normal and lymphocyte-deficient mice. We found that lymphocyte-deficient mice had a higher basal metabolic rate than normal mice with both innate and adaptive immune defence. This suggests that the evolution of the adaptive immune system has not been constrained by energetic costs. Rather, it should have been favoured by the energy savings associated with a combination of innate and adaptive immune defence. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Royal Society of London. Proceedings B. Biological Sciences
volume
269
issue
1493
pages
817 - 821
publisher
Royal Society
external identifiers
  • wos:000175122600007
  • pmid:11958713
  • scopus:41049090932
ISSN
1471-2954
DOI
10.1098/rspb.2001.1953
language
English
LU publication?
yes
id
eab1b5dd-3950-422e-9428-a574b0839537 (old id 145598)
date added to LUP
2007-06-25 11:04:31
date last changed
2017-08-20 03:48:49
@article{eab1b5dd-3950-422e-9428-a574b0839537,
  abstract     = {Vertebrates have evolved an adaptive immune system in addition to the ancestral innate immune system. It is often assumed that a trade-off between costs and benefits of defence governs the evolution of immunological defence, but the costs and benefits specific to the adaptive immune system are poorly known. We used genetically engineered mice lacking lymphocytes (i.e. mice without adaptive, but with innate, immunity) as a model of the ancestral state in the evolution of the vertebrate immune system. To investigate if the magnitude of adaptive defence is constrained by the energetic costs of producing lymphocytes etc., we compared the basal metabolic rate of normal and lymphocyte-deficient mice. We found that lymphocyte-deficient mice had a higher basal metabolic rate than normal mice with both innate and adaptive immune defence. This suggests that the evolution of the adaptive immune system has not been constrained by energetic costs. Rather, it should have been favoured by the energy savings associated with a combination of innate and adaptive immune defence.},
  author       = {Råberg, Lars and Vestberg, Mikael and Hasselquist, Dennis and Holmdahl, Rikard and Svensson, Erik and Nilsson, Jan-Åke},
  issn         = {1471-2954},
  language     = {eng},
  number       = {1493},
  pages        = {817--821},
  publisher    = {Royal Society},
  series       = {Royal Society of London. Proceedings B. Biological Sciences},
  title        = {Basal metabolic rate and the evolution of the adaptive immune system},
  url          = {http://dx.doi.org/10.1098/rspb.2001.1953},
  volume       = {269},
  year         = {2002},
}