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Implementing a feasible exercise programme in an allogeneic haematopoietic stem cell transplantation setting—impact on physical activity and fatigue

Kisch, Annika LU orcid ; Jakobsson, Sofie and Forsberg, Anna LU (2020) In International Journal of Environmental Research and Public Health 17(12).
Abstract

Physical exercise for patients treated with allogeneic haematopoietic stem cell transplantation (allo-HSCT) has shown positive effects on the quality of life and fatigue in experimental trials. However, there is a need for longitudinal evaluation of exercise programmes implemented in a real-world clinical setting. The aim of this prospective study was to evaluate the impact of an exercise programme introduced before allo-HSCT on physical activity and fatigue before, during and after in-patient care. A structured exercise programme, including strength and endurance exercises, was implemented at a Swedish university hospital four weeks before transplantation, continuing during in-patient care and after discharge. Between March 2016 and... (More)

Physical exercise for patients treated with allogeneic haematopoietic stem cell transplantation (allo-HSCT) has shown positive effects on the quality of life and fatigue in experimental trials. However, there is a need for longitudinal evaluation of exercise programmes implemented in a real-world clinical setting. The aim of this prospective study was to evaluate the impact of an exercise programme introduced before allo-HSCT on physical activity and fatigue before, during and after in-patient care. A structured exercise programme, including strength and endurance exercises, was implemented at a Swedish university hospital four weeks before transplantation, continuing during in-patient care and after discharge. Between March 2016 and May 2018, 67 adult patients, 33 women and 34 men with a mean age of 55.5 years participated. Fatigue was measured by the Multidimensional Fatigue Inventory at four time points. The patients documented their exercises on a checklist each week during the entire study period. The fatigue trajectory differed between various sub-groups, thus individualized supervision and support to maintain motivation is needed. In conclusion, a structured yet realistic exercise programme before admission is beneficial for allo-HSCT patients in order to reduce fatigue and prepare them for transplantation both physically and mentally.

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author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Allogeneic haematopoietic stem cell transplantation, Exercise, Fatigue
in
International Journal of Environmental Research and Public Health
volume
17
issue
12
article number
4302
pages
13 pages
publisher
MDPI AG
external identifiers
  • scopus:85086628519
  • pmid:32560160
ISSN
1661-7827
DOI
10.3390/ijerph17124302
language
English
LU publication?
yes
id
1459807b-9c1b-4448-9af5-a345525a3c09
date added to LUP
2020-07-03 10:44:47
date last changed
2025-10-18 01:18:33
@article{1459807b-9c1b-4448-9af5-a345525a3c09,
  abstract     = {{<p>Physical exercise for patients treated with allogeneic haematopoietic stem cell transplantation (allo-HSCT) has shown positive effects on the quality of life and fatigue in experimental trials. However, there is a need for longitudinal evaluation of exercise programmes implemented in a real-world clinical setting. The aim of this prospective study was to evaluate the impact of an exercise programme introduced before allo-HSCT on physical activity and fatigue before, during and after in-patient care. A structured exercise programme, including strength and endurance exercises, was implemented at a Swedish university hospital four weeks before transplantation, continuing during in-patient care and after discharge. Between March 2016 and May 2018, 67 adult patients, 33 women and 34 men with a mean age of 55.5 years participated. Fatigue was measured by the Multidimensional Fatigue Inventory at four time points. The patients documented their exercises on a checklist each week during the entire study period. The fatigue trajectory differed between various sub-groups, thus individualized supervision and support to maintain motivation is needed. In conclusion, a structured yet realistic exercise programme before admission is beneficial for allo-HSCT patients in order to reduce fatigue and prepare them for transplantation both physically and mentally.</p>}},
  author       = {{Kisch, Annika and Jakobsson, Sofie and Forsberg, Anna}},
  issn         = {{1661-7827}},
  keywords     = {{Allogeneic haematopoietic stem cell transplantation; Exercise; Fatigue}},
  language     = {{eng}},
  number       = {{12}},
  publisher    = {{MDPI AG}},
  series       = {{International Journal of Environmental Research and Public Health}},
  title        = {{Implementing a feasible exercise programme in an allogeneic haematopoietic stem cell transplantation setting—impact on physical activity and fatigue}},
  url          = {{http://dx.doi.org/10.3390/ijerph17124302}},
  doi          = {{10.3390/ijerph17124302}},
  volume       = {{17}},
  year         = {{2020}},
}