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Ototoxicity on cochlear nucleus neurons following systemic application of gentamicin

Xu, Min; Hu, Hai-Tao; Jin, Zhe LU ; Chen, Gang; Wang, Wei-Xi; Fan, Yu-Lin; Anniko, Matti and Duan, Maoli (2009) In Acta Oto-Laryngologica 129(7). p.745-748
Abstract
Conclusion. The gentamicin-induced pathological alteration in the cochlear nucleus is not exclusively a secondary consequence of the damage in the cochlea. Instead, the toxic effect of gentamicin on the cochlear nucleus may occur simultaneously or even earlier than that on the cochlea. Objectives. To investigate the pathological alteration of cochlear nucleus neurons in guinea pigs following systemic application of gentamicin. Materials and methods. Guinea pigs were injected with gentamicin for I day, 3 days, I week, 2 weeks, and 3 weeks, respectively. In gentamicin-treated animals, the hearing function was evaluated by measuring the auditory brainstem response (ABR). The number and cross-sectional area of substance P-positive neurons in... (More)
Conclusion. The gentamicin-induced pathological alteration in the cochlear nucleus is not exclusively a secondary consequence of the damage in the cochlea. Instead, the toxic effect of gentamicin on the cochlear nucleus may occur simultaneously or even earlier than that on the cochlea. Objectives. To investigate the pathological alteration of cochlear nucleus neurons in guinea pigs following systemic application of gentamicin. Materials and methods. Guinea pigs were injected with gentamicin for I day, 3 days, I week, 2 weeks, and 3 weeks, respectively. In gentamicin-treated animals, the hearing function was evaluated by measuring the auditory brainstem response (ABR). The number and cross-sectional area of substance P-positive neurons in the cochlear nucleus were also measured. Results. The threshold of ABR and the number of substance P-positive neurons in the cochlear nucleus were significantly increased after I week and 3 days of injection of gentamicin, respectively. The cross-sectional area of substance P-positive neurons in the cochlear nucleus was significantly reduced after 1-day injection of gentamicin. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
substance P, immunohistochemistry, hearing loss, Cochlear nucleus, gentamicin
in
Acta Oto-Laryngologica
volume
129
issue
7
pages
745 - 748
publisher
Taylor & Francis
external identifiers
  • wos:000268569900008
  • scopus:71949109848
ISSN
1651-2251
DOI
10.1080/00016480802454716
language
English
LU publication?
yes
id
80a06afd-a743-4806-83d7-e078a0bb2683 (old id 1460165)
date added to LUP
2009-08-31 11:07:12
date last changed
2017-03-05 04:01:11
@article{80a06afd-a743-4806-83d7-e078a0bb2683,
  abstract     = {Conclusion. The gentamicin-induced pathological alteration in the cochlear nucleus is not exclusively a secondary consequence of the damage in the cochlea. Instead, the toxic effect of gentamicin on the cochlear nucleus may occur simultaneously or even earlier than that on the cochlea. Objectives. To investigate the pathological alteration of cochlear nucleus neurons in guinea pigs following systemic application of gentamicin. Materials and methods. Guinea pigs were injected with gentamicin for I day, 3 days, I week, 2 weeks, and 3 weeks, respectively. In gentamicin-treated animals, the hearing function was evaluated by measuring the auditory brainstem response (ABR). The number and cross-sectional area of substance P-positive neurons in the cochlear nucleus were also measured. Results. The threshold of ABR and the number of substance P-positive neurons in the cochlear nucleus were significantly increased after I week and 3 days of injection of gentamicin, respectively. The cross-sectional area of substance P-positive neurons in the cochlear nucleus was significantly reduced after 1-day injection of gentamicin.},
  author       = {Xu, Min and Hu, Hai-Tao and Jin, Zhe and Chen, Gang and Wang, Wei-Xi and Fan, Yu-Lin and Anniko, Matti and Duan, Maoli},
  issn         = {1651-2251},
  keyword      = {substance P,immunohistochemistry,hearing loss,Cochlear nucleus,gentamicin},
  language     = {eng},
  number       = {7},
  pages        = {745--748},
  publisher    = {Taylor & Francis},
  series       = {Acta Oto-Laryngologica},
  title        = {Ototoxicity on cochlear nucleus neurons following systemic application of gentamicin},
  url          = {http://dx.doi.org/10.1080/00016480802454716},
  volume       = {129},
  year         = {2009},
}