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Activation of the Human Contact System on Neutrophil Extracellular Traps

Oehmcke, Sonja LU ; Mörgelin, Matthias LU and Herwald, Heiko LU (2009) In Journal of Innate Immunity 1(3). p.225-230
Abstract
Pattern recognition is an integral part of the innate immune system. The human contact system has been shown to interact with the surface of many bacterial and fungal pathogens, and once activated leads to the generation of antimicrobial peptides and the proinflammatory mediator bradykinin. Here we show that apart from these surfaces also neutrophil extracellular traps (NETs) provide a surface that allows the binding and activation of the contact system. In addition, we present evidence that M1 protein, a streptococcal surface protein, in concert with human fibrinogen triggers polymorphonuclear neutrophils to form NETs. Copyright (C) 2009 S. Karger AG, Basel
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Innate, Immunity, Contact system, DNA-protein interaction, Polymorphonuclear leukocytes, Streptococcus
in
Journal of Innate Immunity
volume
1
issue
3
pages
225 - 230
publisher
Karger
external identifiers
  • wos:000268091300007
  • scopus:70349578489
ISSN
1662-811X
DOI
10.1159/000203700
language
English
LU publication?
yes
id
3edba5da-75a3-43b8-b7d2-091a522af8a8 (old id 1461546)
date added to LUP
2009-08-31 11:01:07
date last changed
2017-11-12 03:18:29
@article{3edba5da-75a3-43b8-b7d2-091a522af8a8,
  abstract     = {Pattern recognition is an integral part of the innate immune system. The human contact system has been shown to interact with the surface of many bacterial and fungal pathogens, and once activated leads to the generation of antimicrobial peptides and the proinflammatory mediator bradykinin. Here we show that apart from these surfaces also neutrophil extracellular traps (NETs) provide a surface that allows the binding and activation of the contact system. In addition, we present evidence that M1 protein, a streptococcal surface protein, in concert with human fibrinogen triggers polymorphonuclear neutrophils to form NETs. Copyright (C) 2009 S. Karger AG, Basel},
  author       = {Oehmcke, Sonja and Mörgelin, Matthias and Herwald, Heiko},
  issn         = {1662-811X},
  keyword      = {Innate,Immunity,Contact system,DNA-protein interaction,Polymorphonuclear leukocytes,Streptococcus},
  language     = {eng},
  number       = {3},
  pages        = {225--230},
  publisher    = {Karger},
  series       = {Journal of Innate Immunity},
  title        = {Activation of the Human Contact System on Neutrophil Extracellular Traps},
  url          = {http://dx.doi.org/10.1159/000203700},
  volume       = {1},
  year         = {2009},
}