Activation of the Human Contact System on Neutrophil Extracellular Traps
(2009) In Journal of Innate Immunity 1(3). p.225-230- Abstract
- Pattern recognition is an integral part of the innate immune system. The human contact system has been shown to interact with the surface of many bacterial and fungal pathogens, and once activated leads to the generation of antimicrobial peptides and the proinflammatory mediator bradykinin. Here we show that apart from these surfaces also neutrophil extracellular traps (NETs) provide a surface that allows the binding and activation of the contact system. In addition, we present evidence that M1 protein, a streptococcal surface protein, in concert with human fibrinogen triggers polymorphonuclear neutrophils to form NETs. Copyright (C) 2009 S. Karger AG, Basel
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1461546
- author
- Oehmcke, Sonja
LU
; Mörgelin, Matthias
LU
and Herwald, Heiko
LU
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Innate, Immunity, Contact system, DNA-protein interaction, Polymorphonuclear leukocytes, Streptococcus
- in
- Journal of Innate Immunity
- volume
- 1
- issue
- 3
- pages
- 225 - 230
- publisher
- Karger
- external identifiers
-
- wos:000268091300007
- scopus:70349578489
- ISSN
- 1662-811X
- DOI
- 10.1159/000203700
- language
- English
- LU publication?
- yes
- id
- 3edba5da-75a3-43b8-b7d2-091a522af8a8 (old id 1461546)
- date added to LUP
- 2016-04-01 11:36:59
- date last changed
- 2022-04-20 19:13:55
@article{3edba5da-75a3-43b8-b7d2-091a522af8a8, abstract = {{Pattern recognition is an integral part of the innate immune system. The human contact system has been shown to interact with the surface of many bacterial and fungal pathogens, and once activated leads to the generation of antimicrobial peptides and the proinflammatory mediator bradykinin. Here we show that apart from these surfaces also neutrophil extracellular traps (NETs) provide a surface that allows the binding and activation of the contact system. In addition, we present evidence that M1 protein, a streptococcal surface protein, in concert with human fibrinogen triggers polymorphonuclear neutrophils to form NETs. Copyright (C) 2009 S. Karger AG, Basel}}, author = {{Oehmcke, Sonja and Mörgelin, Matthias and Herwald, Heiko}}, issn = {{1662-811X}}, keywords = {{Innate; Immunity; Contact system; DNA-protein interaction; Polymorphonuclear leukocytes; Streptococcus}}, language = {{eng}}, number = {{3}}, pages = {{225--230}}, publisher = {{Karger}}, series = {{Journal of Innate Immunity}}, title = {{Activation of the Human Contact System on Neutrophil Extracellular Traps}}, url = {{http://dx.doi.org/10.1159/000203700}}, doi = {{10.1159/000203700}}, volume = {{1}}, year = {{2009}}, }