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Increased retinopathy occurrence in type 1 diabetes patients with increased serum levels of the advanced glycation endproduct hydroimidazolone

Fosmark, Dag S.; Berg, Jens P.; Jensen, Aase-Brith; Sandvik, Leiv; Agardh, Elisabet LU ; Agardh, Carl-David LU and Hanssen, Kristian F. (2009) In Acta Ophthalmologica 87(5). p.498-500
Abstract
Purpose: We aimed to investigate associations between serum levels of the advanced glycation endproduct methylglyoxal-derived hydroimidazolone (MG-H1) and retinopathy in a sample of patients with type 1 diabetes. Methods: We conducted a cross-sectional study in a Scandinavian ophthalmology outpatient clinic on 61 randomly selected patients with type 1 diabetes. Blood samples and retinal photographs were taken at the same visit. Serum levels of hydroimidazolone immunoreactivity were determined using an immunoassay, and levels of retinopathy were determined from seven standard field stereo photographs of each eye according to the ETDRS method. Results were compared between patients with and without retinopathy. Results: Hydroimidazolone... (More)
Purpose: We aimed to investigate associations between serum levels of the advanced glycation endproduct methylglyoxal-derived hydroimidazolone (MG-H1) and retinopathy in a sample of patients with type 1 diabetes. Methods: We conducted a cross-sectional study in a Scandinavian ophthalmology outpatient clinic on 61 randomly selected patients with type 1 diabetes. Blood samples and retinal photographs were taken at the same visit. Serum levels of hydroimidazolone immunoreactivity were determined using an immunoassay, and levels of retinopathy were determined from seven standard field stereo photographs of each eye according to the ETDRS method. Results were compared between patients with and without retinopathy. Results: Hydroimidazolone quartiles were significantly associated with retinopathy (p = 0.013). The most profound increase in occurrence of retinopathy was observed from the lowest to the second-lowest hydroimidazolone quartile. Adjusted for duration of diabetes using logistic regression, a significant difference in the presence of retinopathy was found when comparing the lowest quartile with the rest (p = 0.022). Conclusions: In our patients with type 1 diabetes, serum levels of hydroimidazolone were found to be associated with retinopathy. This is in keeping with findings in a larger sample of patients with type 2 diabetes. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
MG-H1, (MG), methylglyoxal, advanced glycation endproducts (AGEs), hydroimidazolone, retinopathy, type 1 diabetes
in
Acta Ophthalmologica
volume
87
issue
5
pages
498 - 500
publisher
Wiley-Blackwell
external identifiers
  • wos:000268214200003
  • scopus:70350511901
ISSN
1755-3768
DOI
10.1111/j.1755-3768.2008.01300.x
language
English
LU publication?
yes
id
e0706f09-ec19-4576-abf3-729d55e3ca06 (old id 1461889)
date added to LUP
2009-08-31 10:51:50
date last changed
2017-11-05 03:33:17
@article{e0706f09-ec19-4576-abf3-729d55e3ca06,
  abstract     = {Purpose: We aimed to investigate associations between serum levels of the advanced glycation endproduct methylglyoxal-derived hydroimidazolone (MG-H1) and retinopathy in a sample of patients with type 1 diabetes. Methods: We conducted a cross-sectional study in a Scandinavian ophthalmology outpatient clinic on 61 randomly selected patients with type 1 diabetes. Blood samples and retinal photographs were taken at the same visit. Serum levels of hydroimidazolone immunoreactivity were determined using an immunoassay, and levels of retinopathy were determined from seven standard field stereo photographs of each eye according to the ETDRS method. Results were compared between patients with and without retinopathy. Results: Hydroimidazolone quartiles were significantly associated with retinopathy (p = 0.013). The most profound increase in occurrence of retinopathy was observed from the lowest to the second-lowest hydroimidazolone quartile. Adjusted for duration of diabetes using logistic regression, a significant difference in the presence of retinopathy was found when comparing the lowest quartile with the rest (p = 0.022). Conclusions: In our patients with type 1 diabetes, serum levels of hydroimidazolone were found to be associated with retinopathy. This is in keeping with findings in a larger sample of patients with type 2 diabetes.},
  author       = {Fosmark, Dag S. and Berg, Jens P. and Jensen, Aase-Brith and Sandvik, Leiv and Agardh, Elisabet and Agardh, Carl-David and Hanssen, Kristian F.},
  issn         = {1755-3768},
  keyword      = {MG-H1,(MG),methylglyoxal,advanced glycation endproducts (AGEs),hydroimidazolone,retinopathy,type 1 diabetes},
  language     = {eng},
  number       = {5},
  pages        = {498--500},
  publisher    = {Wiley-Blackwell},
  series       = {Acta Ophthalmologica},
  title        = {Increased retinopathy occurrence in type 1 diabetes patients with increased serum levels of the advanced glycation endproduct hydroimidazolone},
  url          = {http://dx.doi.org/10.1111/j.1755-3768.2008.01300.x},
  volume       = {87},
  year         = {2009},
}