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Full-thickness biopsy findings in chronic intestinal pseudo-obstruction and enteric dysmotility

Lindberg, G.; Tornblom, H.; Iwarzon, M.; Nyberg, B.; Martin, J. E. and Veress, Bela LU (2009) In Gut 58(8). p.1084-1090
Abstract
Background and Aims: Small bowel manometry is increasingly used in the clinical investigation of patients with symptoms of intestinal motor dysfunction. Enteric dysmotility (ED) has been suggested as a new diagnostic term for patients with abnormal intestinal motor activity but no radiological signs of chronic intestinal pseudo-obstruction (CIP). Histopathological features of adult patients with ED and CIP have been compared in a large case series to study differences and similarities between the two diagnostic groups. Methods: Routine staining and an extensive panel of immunohistochemical stains on transversal and tangential cuts from full-thickness biopsies of the small bowel were used. Results: 39 females and 11 males with CIP and 58... (More)
Background and Aims: Small bowel manometry is increasingly used in the clinical investigation of patients with symptoms of intestinal motor dysfunction. Enteric dysmotility (ED) has been suggested as a new diagnostic term for patients with abnormal intestinal motor activity but no radiological signs of chronic intestinal pseudo-obstruction (CIP). Histopathological features of adult patients with ED and CIP have been compared in a large case series to study differences and similarities between the two diagnostic groups. Methods: Routine staining and an extensive panel of immunohistochemical stains on transversal and tangential cuts from full-thickness biopsies of the small bowel were used. Results: 39 females and 11 males with CIP and 58 females and 7 males with ED were investigated. The underlying lesion was more often a visceral myopathy (22% vs 5%) or neuromyopathy (30% vs 12%) in patients with CIP than in those with ED, whereas the predominant lesion in ED was neuropathy with inflammation. Conclusion: CIP in adults is associated with very different underlying pathology, whereas ED is more homogeneously associated with neuropathy in the enteric nervous system. Neuropathy of enteric ganglia with inflammation seems to be the most common cause for measurable disturbances of intestinal motor function. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Gut
volume
58
issue
8
pages
1084 - 1090
publisher
BMJ Publishing Group
external identifiers
  • wos:000267903400015
  • scopus:67650215095
ISSN
1468-3288
DOI
10.1136/gut.2008.148296
language
English
LU publication?
yes
id
38beed01-4386-40b3-891f-39f7ee76ee3c (old id 1462694)
date added to LUP
2009-08-31 10:59:07
date last changed
2017-12-10 03:58:34
@article{38beed01-4386-40b3-891f-39f7ee76ee3c,
  abstract     = {Background and Aims: Small bowel manometry is increasingly used in the clinical investigation of patients with symptoms of intestinal motor dysfunction. Enteric dysmotility (ED) has been suggested as a new diagnostic term for patients with abnormal intestinal motor activity but no radiological signs of chronic intestinal pseudo-obstruction (CIP). Histopathological features of adult patients with ED and CIP have been compared in a large case series to study differences and similarities between the two diagnostic groups. Methods: Routine staining and an extensive panel of immunohistochemical stains on transversal and tangential cuts from full-thickness biopsies of the small bowel were used. Results: 39 females and 11 males with CIP and 58 females and 7 males with ED were investigated. The underlying lesion was more often a visceral myopathy (22% vs 5%) or neuromyopathy (30% vs 12%) in patients with CIP than in those with ED, whereas the predominant lesion in ED was neuropathy with inflammation. Conclusion: CIP in adults is associated with very different underlying pathology, whereas ED is more homogeneously associated with neuropathy in the enteric nervous system. Neuropathy of enteric ganglia with inflammation seems to be the most common cause for measurable disturbances of intestinal motor function.},
  author       = {Lindberg, G. and Tornblom, H. and Iwarzon, M. and Nyberg, B. and Martin, J. E. and Veress, Bela},
  issn         = {1468-3288},
  language     = {eng},
  number       = {8},
  pages        = {1084--1090},
  publisher    = {BMJ Publishing Group},
  series       = {Gut},
  title        = {Full-thickness biopsy findings in chronic intestinal pseudo-obstruction and enteric dysmotility},
  url          = {http://dx.doi.org/10.1136/gut.2008.148296},
  volume       = {58},
  year         = {2009},
}