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Gastrointestinal neuromuscular pathology: guidelines for histological techniques and reporting on behalf of the Gastro 2009 International Working Group

Knowles, Charles H.; De Giorgio, Roberto; Kapur, Raj P.; Bruder, Elisabeth; Farrugia, Gianrico; Geboes, Karel; Gershon, Michael D.; Hutson, John; Lindberg, Greger and Martin, Joanne E., et al. (2009) In Acta Neuropathologica 118(2). p.271-301
Abstract
The term gastrointestinal neuromuscular disease describes a clinically heterogeneous group of disorders of children and adults in which symptoms are presumed or proven to arise as a result of neuromuscular, including interstitial cell of Cajal, dysfunction. Such disorders commonly have impaired motor activity, i.e. slowed or obstructed transit with radiological evidence of transient or persistent visceral dilatation. Whilst sensorimotor abnormalities have been demonstrated by a variety of methods in these conditions, standards for histopathological reporting remain relatively neglected. Significant differences in methodologies and expertise continue to confound the reliable delineation of normality and specificity of particular... (More)
The term gastrointestinal neuromuscular disease describes a clinically heterogeneous group of disorders of children and adults in which symptoms are presumed or proven to arise as a result of neuromuscular, including interstitial cell of Cajal, dysfunction. Such disorders commonly have impaired motor activity, i.e. slowed or obstructed transit with radiological evidence of transient or persistent visceral dilatation. Whilst sensorimotor abnormalities have been demonstrated by a variety of methods in these conditions, standards for histopathological reporting remain relatively neglected. Significant differences in methodologies and expertise continue to confound the reliable delineation of normality and specificity of particular pathological changes for disease. Such issues require urgent clarification to standardize acquisition and handling of tissue specimens, interpretation of findings and make informed decisions on risk-benefit of full-thickness tissue biopsy of bowel or other diagnostic procedures. Such information will also allow increased certainty of diagnosis, facilitating factual discussion between patients and caregivers, as well as giving prognostic and therapeutic information. The following report, produced by an international working group, using established consensus methodology, presents proposed guidelines on histological techniques and reporting for adult and paediatric gastrointestinal neuromuscular pathology. The report addresses the main areas of histopathological practice as confronted by the pathologist, including suction rectal biopsy and full-thickness tissue obtained with diagnostic or therapeutic intent. For each, indications, safe acquisition of tissue, histological techniques, reporting and referral recommendations are presented. (Less)
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organization
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Contribution to journal
publication status
published
subject
keywords
Intestinal, Suction rectal biopsy, pseudo-obstruction, Hirschsprung disease, Histopathology, Interstitial cells of Cajal, Enteric neuropathy, Enteric myopathy
in
Acta Neuropathologica
volume
118
issue
2
pages
271 - 301
publisher
Springer
external identifiers
  • wos:000267776900006
  • scopus:67650671504
ISSN
1432-0533
DOI
10.1007/s00401-009-0527-y
language
English
LU publication?
yes
id
ece18ced-01ed-4493-b763-c12b61148d83 (old id 1462891)
date added to LUP
2009-08-31 10:57:55
date last changed
2017-09-24 03:55:17
@misc{ece18ced-01ed-4493-b763-c12b61148d83,
  abstract     = {The term gastrointestinal neuromuscular disease describes a clinically heterogeneous group of disorders of children and adults in which symptoms are presumed or proven to arise as a result of neuromuscular, including interstitial cell of Cajal, dysfunction. Such disorders commonly have impaired motor activity, i.e. slowed or obstructed transit with radiological evidence of transient or persistent visceral dilatation. Whilst sensorimotor abnormalities have been demonstrated by a variety of methods in these conditions, standards for histopathological reporting remain relatively neglected. Significant differences in methodologies and expertise continue to confound the reliable delineation of normality and specificity of particular pathological changes for disease. Such issues require urgent clarification to standardize acquisition and handling of tissue specimens, interpretation of findings and make informed decisions on risk-benefit of full-thickness tissue biopsy of bowel or other diagnostic procedures. Such information will also allow increased certainty of diagnosis, facilitating factual discussion between patients and caregivers, as well as giving prognostic and therapeutic information. The following report, produced by an international working group, using established consensus methodology, presents proposed guidelines on histological techniques and reporting for adult and paediatric gastrointestinal neuromuscular pathology. The report addresses the main areas of histopathological practice as confronted by the pathologist, including suction rectal biopsy and full-thickness tissue obtained with diagnostic or therapeutic intent. For each, indications, safe acquisition of tissue, histological techniques, reporting and referral recommendations are presented.},
  author       = {Knowles, Charles H. and De Giorgio, Roberto and Kapur, Raj P. and Bruder, Elisabeth and Farrugia, Gianrico and Geboes, Karel and Gershon, Michael D. and Hutson, John and Lindberg, Greger and Martin, Joanne E. and Meier-Ruge, William A. and Milla, Peter J. and Smith, Virpi V. and Vandervinden, Jean Marie and Veress, Bela and Wedel, Thilo},
  issn         = {1432-0533},
  keyword      = {Intestinal,Suction rectal biopsy,pseudo-obstruction,Hirschsprung disease,Histopathology,Interstitial cells of Cajal,Enteric neuropathy,Enteric myopathy},
  language     = {eng},
  number       = {2},
  pages        = {271--301},
  publisher    = {Springer},
  series       = {Acta Neuropathologica},
  title        = {Gastrointestinal neuromuscular pathology: guidelines for histological techniques and reporting on behalf of the Gastro 2009 International Working Group},
  url          = {http://dx.doi.org/10.1007/s00401-009-0527-y},
  volume       = {118},
  year         = {2009},
}