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Persistent Decline in Longitudinal and Radial Strain After Coronary Microembolization Detected on Velocity Encoded Phase Contrast Magnetic Resonance Imaging

Dicks, Demetrius L.; Carlsson, Marcus; Heiberg, Einar LU ; Martin, Alastair; Saloner, David; Arheden, Håkan LU and Saeed, Maythem (2009) In Journal of Magnetic Resonance Imaging 30(1). p.69-76
Abstract
Purpose: To use velocity-encoded phase contrast (PC) MRI in assessing the effect of coronary microembolization on longitudinal and radial myocardial strain. Materials and Methods: A combined X-ray and MR system (XMR) was used for selective left anterior descending artery catheterization and microinfarct assessment in swine (n = 6). The embolized area at risk was defined on perfusion MRI followed by administration of a 7500 count (size = 100-300 mu m) of the embolic agent. Quantification of strain and microinfarction was performed at 1 h and 1 week using PC-MRI and delayed enhancement (DE) MRI, respectively. At postmortem, sliced hearts were stained to define microinfarction. Results: Baseline longitudinal and radial strain did not differ... (More)
Purpose: To use velocity-encoded phase contrast (PC) MRI in assessing the effect of coronary microembolization on longitudinal and radial myocardial strain. Materials and Methods: A combined X-ray and MR system (XMR) was used for selective left anterior descending artery catheterization and microinfarct assessment in swine (n = 6). The embolized area at risk was defined on perfusion MRI followed by administration of a 7500 count (size = 100-300 mu m) of the embolic agent. Quantification of strain and microinfarction was performed at 1 h and 1 week using PC-MRI and delayed enhancement (DE) MRI, respectively. At postmortem, sliced hearts were stained to define microinfarction. Results: Baseline longitudinal and radial strain did not differ between area-at-risk and remote myocardium. The embolized territory (area at risk) showed significant decline in longitudinal strain from -11.5 +/- 3.2% to 1.8 +/- 2.5% at 1 h (P < 0.05) and -3.9 +/- 1.1% at 1 week (P < 0.05). Similarly, regional radial strain progressively declined from 23.6 +/- 2.5% at baseline to 12.5 +/- 3.7% at 1 h (P < 0.05) and 4.8 +/- 5.0% at 1 week (P < 0.01). The size of microinfarction was not significantly different between DE-MRI and histochemical staining. Conclusion: PC-MRI is sensitive in assessing changes in regional longitudinal and radial strain after coronary embolization. Longitudinal and radial strain of the hyperenhanced patchy microinfarction demonstrates persistent decline over the course of 1 week. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
coronary intervention, microinfarction, myocardial strain, MR imaging
in
Journal of Magnetic Resonance Imaging
volume
30
issue
1
pages
69 - 76
publisher
John Wiley & Sons
external identifiers
  • wos:000267452600010
  • scopus:67650151591
ISSN
1522-2586
DOI
10.1002/jmri.21773
language
English
LU publication?
yes
id
e1297bb8-993a-4663-8ae8-06cc451675ea (old id 1463079)
date added to LUP
2009-08-31 10:43:00
date last changed
2017-01-01 05:18:55
@article{e1297bb8-993a-4663-8ae8-06cc451675ea,
  abstract     = {Purpose: To use velocity-encoded phase contrast (PC) MRI in assessing the effect of coronary microembolization on longitudinal and radial myocardial strain. Materials and Methods: A combined X-ray and MR system (XMR) was used for selective left anterior descending artery catheterization and microinfarct assessment in swine (n = 6). The embolized area at risk was defined on perfusion MRI followed by administration of a 7500 count (size = 100-300 mu m) of the embolic agent. Quantification of strain and microinfarction was performed at 1 h and 1 week using PC-MRI and delayed enhancement (DE) MRI, respectively. At postmortem, sliced hearts were stained to define microinfarction. Results: Baseline longitudinal and radial strain did not differ between area-at-risk and remote myocardium. The embolized territory (area at risk) showed significant decline in longitudinal strain from -11.5 +/- 3.2% to 1.8 +/- 2.5% at 1 h (P &lt; 0.05) and -3.9 +/- 1.1% at 1 week (P &lt; 0.05). Similarly, regional radial strain progressively declined from 23.6 +/- 2.5% at baseline to 12.5 +/- 3.7% at 1 h (P &lt; 0.05) and 4.8 +/- 5.0% at 1 week (P &lt; 0.01). The size of microinfarction was not significantly different between DE-MRI and histochemical staining. Conclusion: PC-MRI is sensitive in assessing changes in regional longitudinal and radial strain after coronary embolization. Longitudinal and radial strain of the hyperenhanced patchy microinfarction demonstrates persistent decline over the course of 1 week.},
  author       = {Dicks, Demetrius L. and Carlsson, Marcus and Heiberg, Einar and Martin, Alastair and Saloner, David and Arheden, Håkan and Saeed, Maythem},
  issn         = {1522-2586},
  keyword      = {coronary intervention,microinfarction,myocardial strain,MR imaging},
  language     = {eng},
  number       = {1},
  pages        = {69--76},
  publisher    = {John Wiley & Sons},
  series       = {Journal of Magnetic Resonance Imaging},
  title        = {Persistent Decline in Longitudinal and Radial Strain After Coronary Microembolization Detected on Velocity Encoded Phase Contrast Magnetic Resonance Imaging},
  url          = {http://dx.doi.org/10.1002/jmri.21773},
  volume       = {30},
  year         = {2009},
}