Histologic and Manometric Studies on the Esophagus Following Endoscopic Sclerotherapy
(2009) In Digestive Diseases and Sciences 54(8). p.1713-1719- Abstract
- Objective The aim of this work was to study the histologic and manometric changes in the distal esophagus beyond 2 years following endoscopic sclerotherapy (EST) and/or surgical intervention, and to try to understand the etiological factors associated with these changes. Patients and interventions Forty patients, with an average age of 61.5 years, were studied for 2-12 years following sclerotherapy and/or surgical intervention. The causes of liver disease were alcoholic cirrhosis (78.6%), primary biliary cirrhosis (14.3%), and chronic aggressive hepatitis (7.1%). A predominant number of cases (65%) had a mesocaval interposition shunt due to the failure of EST, 32.5% EST alone, and 2.5% esophageal devascularization. All patients had... (More)
- Objective The aim of this work was to study the histologic and manometric changes in the distal esophagus beyond 2 years following endoscopic sclerotherapy (EST) and/or surgical intervention, and to try to understand the etiological factors associated with these changes. Patients and interventions Forty patients, with an average age of 61.5 years, were studied for 2-12 years following sclerotherapy and/or surgical intervention. The causes of liver disease were alcoholic cirrhosis (78.6%), primary biliary cirrhosis (14.3%), and chronic aggressive hepatitis (7.1%). A predominant number of cases (65%) had a mesocaval interposition shunt due to the failure of EST, 32.5% EST alone, and 2.5% esophageal devascularization. All patients had esophageal manometry following mucosal biopsies taken in duplicate endoscopically from three levels of the distal esophagus. Results In the EST and shunt groups, 88.5% had manometric abnormalities, esophagitis, and chronic inflammatory changes. In the EST group, all but two patients had manometric abnormalities and chronic inflammatory changes. Analysis of the patient groups on the basis of the number of EST sessions and the amount of sclerosant injected showed that both histologic changes and dysmotility were more profound in those treated over five times with EST. The differences were significant. Conclusion It appears that EST causes persistent manometric abnormalities and chronic inflammatory changes in the distal esophagus, the severity of which seems to vary directly with the frequency of sclerotherapy and not amount of sclerosant injected. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1463316
- author
- Sharma, Peeyush ; Hagerstrand, Inga LU and Sharma, Dave Krishan
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- sphincter (LES), Lower esophageal, Manometry, Endoscopic sclerotherapy (EST), Esophagus, Peristalsis, Histology
- in
- Digestive Diseases and Sciences
- volume
- 54
- issue
- 8
- pages
- 1713 - 1719
- publisher
- Springer
- external identifiers
-
- wos:000267485400016
- scopus:67649945532
- ISSN
- 1573-2568
- DOI
- 10.1007/s10620-008-0536-z
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pathology, (Lund) (013030000)
- id
- 4aec8367-a9ff-4d67-9f88-63e6c2f99e74 (old id 1463316)
- date added to LUP
- 2016-04-01 11:50:23
- date last changed
- 2022-04-20 22:36:12
@article{4aec8367-a9ff-4d67-9f88-63e6c2f99e74,
abstract = {{Objective The aim of this work was to study the histologic and manometric changes in the distal esophagus beyond 2 years following endoscopic sclerotherapy (EST) and/or surgical intervention, and to try to understand the etiological factors associated with these changes. Patients and interventions Forty patients, with an average age of 61.5 years, were studied for 2-12 years following sclerotherapy and/or surgical intervention. The causes of liver disease were alcoholic cirrhosis (78.6%), primary biliary cirrhosis (14.3%), and chronic aggressive hepatitis (7.1%). A predominant number of cases (65%) had a mesocaval interposition shunt due to the failure of EST, 32.5% EST alone, and 2.5% esophageal devascularization. All patients had esophageal manometry following mucosal biopsies taken in duplicate endoscopically from three levels of the distal esophagus. Results In the EST and shunt groups, 88.5% had manometric abnormalities, esophagitis, and chronic inflammatory changes. In the EST group, all but two patients had manometric abnormalities and chronic inflammatory changes. Analysis of the patient groups on the basis of the number of EST sessions and the amount of sclerosant injected showed that both histologic changes and dysmotility were more profound in those treated over five times with EST. The differences were significant. Conclusion It appears that EST causes persistent manometric abnormalities and chronic inflammatory changes in the distal esophagus, the severity of which seems to vary directly with the frequency of sclerotherapy and not amount of sclerosant injected.}},
author = {{Sharma, Peeyush and Hagerstrand, Inga and Sharma, Dave Krishan}},
issn = {{1573-2568}},
keywords = {{sphincter (LES); Lower esophageal; Manometry; Endoscopic sclerotherapy (EST); Esophagus; Peristalsis; Histology}},
language = {{eng}},
number = {{8}},
pages = {{1713--1719}},
publisher = {{Springer}},
series = {{Digestive Diseases and Sciences}},
title = {{Histologic and Manometric Studies on the Esophagus Following Endoscopic Sclerotherapy}},
url = {{http://dx.doi.org/10.1007/s10620-008-0536-z}},
doi = {{10.1007/s10620-008-0536-z}},
volume = {{54}},
year = {{2009}},
}