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Low levels of insulin-like growth-factor-binding protein-1 (IGFBP-1) are prospectively associated with the incidence of type 2 diabetes and impaired glucose tolerance (IGT): The Soderakra Cardiovascular Risk Factor Study

Petersson, U.; Oestgren, C. J.; Brudin, L.; Brismar, K. and Nilsson, Peter LU (2009) In Diabetes & Metabolism1996-01-01+01:00 35(3). p.198-205
Abstract
Aim. - To explore the association between baseline levels of insulin-like growth-factor-binding protein-1 (IGFBP-1), a marker of insulin sensitivity, and the development of type 2 diabetes or impaired glucose tolerance (IGT) in a specifically defined middle-aged population. Methods. - This cross-sectional population-based screening study was conducted in 1989-1990 and included baseline data for 664 non-diabetic subjects aged 40-59 years. Clinical data were collected and blood samples analyzed for blood glucose, serum lipids and insulin. Blood specimens were frozen at baseline and later analyzed for IGF-I, IGFBP-1 and C-reactive protein (CRP). At the follow-up in 2006, the incidence of type 2 diabetes and IGT was reported based on... (More)
Aim. - To explore the association between baseline levels of insulin-like growth-factor-binding protein-1 (IGFBP-1), a marker of insulin sensitivity, and the development of type 2 diabetes or impaired glucose tolerance (IGT) in a specifically defined middle-aged population. Methods. - This cross-sectional population-based screening study was conducted in 1989-1990 and included baseline data for 664 non-diabetic subjects aged 40-59 years. Clinical data were collected and blood samples analyzed for blood glucose, serum lipids and insulin. Blood specimens were frozen at baseline and later analyzed for IGF-I, IGFBP-1 and C-reactive protein (CRP). At the follow-up in 2006, the incidence of type 2 diabetes and IGT was reported based on primary-care medical records. Results. - During the 17-year observation period, 42 subjects (6.3%) developed type 2 diabetes/IGT. Those in the lowest quintile of IGFBP-1 (<= 24 mu g/L) at baseline had a diabetes incidence of 12.6% while, in the highest quintile of IGFBP-1 (>= 59 mu g/L), the incidence was 1.5%. Cox's proportional-hazards model regression analyses were used to determine the incidence of type 2 diabetes/IGT, corrected for age and gender, in relation to IGFBP-1, CRP and waist circumference. Subjects in the lowest IGFBP-1 quintile showed an independently increased risk of type 2 diabetes/IGT [hazards ratio (HR): 3.54; 95% Cl 1.18-10.6; P = 0.024]. For CRP and waist circumference, the corresponding figures were HR: 6.81; 95% Cl 2.50-18.6; P < 0.001 and HR: 3.33; 95% Cl 1.47-7.6; P = 0.004, respectively. Conclusion. - Low levels of IGFBP-1 predicted the long-term development of type 2 diabetes or IGT in a middle-aged population. The association was independent of CRP and abdominal obesity. (C) 2009 Elsevier Masson SAS. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Longitudinal study, Type 2 diabetes, Screening, Prediction, CRP, IGFBP-1
in
Diabetes & Metabolism1996-01-01+01:00
volume
35
issue
3
pages
198 - 205
publisher
Masson Editeur
external identifiers
  • wos:000267655700006
  • scopus:67349108377
ISSN
1878-1780
DOI
10.1016/j.diabet.2008.11.003
language
English
LU publication?
yes
id
5b7ac6c9-a387-48b4-9a8e-1d56a1b5c2bb (old id 1463321)
date added to LUP
2009-08-31 11:02:27
date last changed
2017-10-29 03:58:28
@article{5b7ac6c9-a387-48b4-9a8e-1d56a1b5c2bb,
  abstract     = {Aim. - To explore the association between baseline levels of insulin-like growth-factor-binding protein-1 (IGFBP-1), a marker of insulin sensitivity, and the development of type 2 diabetes or impaired glucose tolerance (IGT) in a specifically defined middle-aged population. Methods. - This cross-sectional population-based screening study was conducted in 1989-1990 and included baseline data for 664 non-diabetic subjects aged 40-59 years. Clinical data were collected and blood samples analyzed for blood glucose, serum lipids and insulin. Blood specimens were frozen at baseline and later analyzed for IGF-I, IGFBP-1 and C-reactive protein (CRP). At the follow-up in 2006, the incidence of type 2 diabetes and IGT was reported based on primary-care medical records. Results. - During the 17-year observation period, 42 subjects (6.3%) developed type 2 diabetes/IGT. Those in the lowest quintile of IGFBP-1 (&lt;= 24 mu g/L) at baseline had a diabetes incidence of 12.6% while, in the highest quintile of IGFBP-1 (&gt;= 59 mu g/L), the incidence was 1.5%. Cox's proportional-hazards model regression analyses were used to determine the incidence of type 2 diabetes/IGT, corrected for age and gender, in relation to IGFBP-1, CRP and waist circumference. Subjects in the lowest IGFBP-1 quintile showed an independently increased risk of type 2 diabetes/IGT [hazards ratio (HR): 3.54; 95% Cl 1.18-10.6; P = 0.024]. For CRP and waist circumference, the corresponding figures were HR: 6.81; 95% Cl 2.50-18.6; P &lt; 0.001 and HR: 3.33; 95% Cl 1.47-7.6; P = 0.004, respectively. Conclusion. - Low levels of IGFBP-1 predicted the long-term development of type 2 diabetes or IGT in a middle-aged population. The association was independent of CRP and abdominal obesity. (C) 2009 Elsevier Masson SAS. All rights reserved.},
  author       = {Petersson, U. and Oestgren, C. J. and Brudin, L. and Brismar, K. and Nilsson, Peter},
  issn         = {1878-1780},
  keyword      = {Longitudinal study,Type 2 diabetes,Screening,Prediction,CRP,IGFBP-1},
  language     = {eng},
  number       = {3},
  pages        = {198--205},
  publisher    = {Masson Editeur},
  series       = {Diabetes & Metabolism1996-01-01+01:00},
  title        = {Low levels of insulin-like growth-factor-binding protein-1 (IGFBP-1) are prospectively associated with the incidence of type 2 diabetes and impaired glucose tolerance (IGT): The Soderakra Cardiovascular Risk Factor Study},
  url          = {http://dx.doi.org/10.1016/j.diabet.2008.11.003},
  volume       = {35},
  year         = {2009},
}