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Demonstration of fluid channels in human dura and their relationship to age and intradural bleeding

Squier, W. ; Lindberg, E LU ; Mack, J. and Darby, S. (2009) In Child's Nervous System 25(8). p.925-931
Abstract
This paper aims to make a systematic study of human dura to establish the presence of fluid transport channels and their relationship to age. Samples of parasagittal dura from autopsy cases from mid-gestation to the ninth decade were examined by light microscopy. We have demonstrated the presence of unlined rounded spaces, uncommon in the fetus and neonate but increasingly evident after 30 weeks of postnatal life. We have shown that intradural bleeding is inversely correlated with the presence of these channels and with age. We suggest that dural maturation, involving the development of arachnoid granulations, may be related to dilatation of intradural fluid channels, allowing them to be identified histologically. The risk of reflux of... (More)
This paper aims to make a systematic study of human dura to establish the presence of fluid transport channels and their relationship to age. Samples of parasagittal dura from autopsy cases from mid-gestation to the ninth decade were examined by light microscopy. We have demonstrated the presence of unlined rounded spaces, uncommon in the fetus and neonate but increasingly evident after 30 weeks of postnatal life. We have shown that intradural bleeding is inversely correlated with the presence of these channels and with age. We suggest that dural maturation, involving the development of arachnoid granulations, may be related to dilatation of intradural fluid channels, allowing them to be identified histologically. The risk of reflux of blood into the dura appears to reduce with age. (Less)
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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Dural bleeding, Infant, Dura, CSF transport, Arachnoid granulations
in
Child's Nervous System
volume
25
issue
8
pages
925 - 931
publisher
Springer
external identifiers
  • wos:000267484800004
  • scopus:67749084125
ISSN
1433-0350
DOI
10.1007/s00381-009-0888-5
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pathology, (Lund) (013030000), Pathology (Malmö) (013031000)
id
97063c1d-1019-4cb0-80f3-fc1d56932981 (old id 1463375)
date added to LUP
2016-04-01 12:12:15
date last changed
2021-06-08 05:51:45
@article{97063c1d-1019-4cb0-80f3-fc1d56932981,
  abstract     = {This paper aims to make a systematic study of human dura to establish the presence of fluid transport channels and their relationship to age. Samples of parasagittal dura from autopsy cases from mid-gestation to the ninth decade were examined by light microscopy. We have demonstrated the presence of unlined rounded spaces, uncommon in the fetus and neonate but increasingly evident after 30 weeks of postnatal life. We have shown that intradural bleeding is inversely correlated with the presence of these channels and with age. We suggest that dural maturation, involving the development of arachnoid granulations, may be related to dilatation of intradural fluid channels, allowing them to be identified histologically. The risk of reflux of blood into the dura appears to reduce with age.},
  author       = {Squier, W. and Lindberg, E and Mack, J. and Darby, S.},
  issn         = {1433-0350},
  language     = {eng},
  number       = {8},
  pages        = {925--931},
  publisher    = {Springer},
  series       = {Child's Nervous System},
  title        = {Demonstration of fluid channels in human dura and their relationship to age and intradural bleeding},
  url          = {http://dx.doi.org/10.1007/s00381-009-0888-5},
  doi          = {10.1007/s00381-009-0888-5},
  volume       = {25},
  year         = {2009},
}