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Prognostic Significance of Stromal Platelet-Derived Growth Factor beta-Receptor Expression in Human Breast Cancer

Paulsson, Janna; Sjoblom, Tobias; Micke, Patrick; Ponten, Fredrik; Landberg, Goran; Heldin, Carl-Henrik; Bergh, Jonas; Brennan, Donal J.; Jirström, Karin LU and Ostman, Arne (2009) In American Journal of Pathology 175(1). p.334-341
Abstract
This study systematically analyzes platelet-derived growth factor (PDGF) receptor expression in six types of common tumors as well as examines associations between PDGF beta-receptor status and clinicopathological characteristics in breast cancer. PDGF receptor expression was determined by immunohistochemistry on tumor tissue microarrays. Breast tumor data were combined with prognostic factors and related to outcome endpoints. PDGF alpha- and beta-receptors were independently expressed, at variable frequencies, in the tumor stroma of all tested tumor types. There was a significant association between PDGF beta-receptor expression on fibroblasts and perivascular cells in individual colon and prostate tumors. In breast cancer, high stromal... (More)
This study systematically analyzes platelet-derived growth factor (PDGF) receptor expression in six types of common tumors as well as examines associations between PDGF beta-receptor status and clinicopathological characteristics in breast cancer. PDGF receptor expression was determined by immunohistochemistry on tumor tissue microarrays. Breast tumor data were combined with prognostic factors and related to outcome endpoints. PDGF alpha- and beta-receptors were independently expressed, at variable frequencies, in the tumor stroma of all tested tumor types. There was a significant association between PDGF beta-receptor expression on fibroblasts and perivascular cells in individual colon and prostate tumors. In breast cancer, high stromal PDGF beta-receptor expression was significantly associated with high histopathological grade, estrogen receptor negativity, and high HER2 expression. High stromal PDGF beta-receptor expression was correlated with significantly shorter recurrence-free and breast cancer-specific survival. The prognostic significance of stromal PDGF beta-receptor expression was particularly prominent in tumors from premenopausal women. Stromal PDGF alpha- and beta-receptor expression is a common, but variable and independent, property of solid tumors. in breast cancer, stromal PDGF beta-receptor expression significantly correlates with less favorable clinicopatho-logical parameters and shorter survival. These findings highlight the prognostic significance of stromal markers and should be considered in ongoing clinical development of PDGF receptor inhibitors. (Am J Pathol 2009, 175.334-341; DOI: 10.2353/ajpath.2009.081030) (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
American Journal of Pathology
volume
175
issue
1
pages
334 - 341
publisher
American Society for Investigative Pathology
external identifiers
  • wos:000267508600031
  • scopus:67649975270
ISSN
1525-2191
DOI
10.2353/ajpath.2009.081030
language
English
LU publication?
yes
id
f4fc74e4-866e-4cd6-8500-a91b89ca2a77 (old id 1463500)
date added to LUP
2009-08-31 11:02:18
date last changed
2017-12-10 03:49:25
@article{f4fc74e4-866e-4cd6-8500-a91b89ca2a77,
  abstract     = {This study systematically analyzes platelet-derived growth factor (PDGF) receptor expression in six types of common tumors as well as examines associations between PDGF beta-receptor status and clinicopathological characteristics in breast cancer. PDGF receptor expression was determined by immunohistochemistry on tumor tissue microarrays. Breast tumor data were combined with prognostic factors and related to outcome endpoints. PDGF alpha- and beta-receptors were independently expressed, at variable frequencies, in the tumor stroma of all tested tumor types. There was a significant association between PDGF beta-receptor expression on fibroblasts and perivascular cells in individual colon and prostate tumors. In breast cancer, high stromal PDGF beta-receptor expression was significantly associated with high histopathological grade, estrogen receptor negativity, and high HER2 expression. High stromal PDGF beta-receptor expression was correlated with significantly shorter recurrence-free and breast cancer-specific survival. The prognostic significance of stromal PDGF beta-receptor expression was particularly prominent in tumors from premenopausal women. Stromal PDGF alpha- and beta-receptor expression is a common, but variable and independent, property of solid tumors. in breast cancer, stromal PDGF beta-receptor expression significantly correlates with less favorable clinicopatho-logical parameters and shorter survival. These findings highlight the prognostic significance of stromal markers and should be considered in ongoing clinical development of PDGF receptor inhibitors. (Am J Pathol 2009, 175.334-341; DOI: 10.2353/ajpath.2009.081030)},
  author       = {Paulsson, Janna and Sjoblom, Tobias and Micke, Patrick and Ponten, Fredrik and Landberg, Goran and Heldin, Carl-Henrik and Bergh, Jonas and Brennan, Donal J. and Jirström, Karin and Ostman, Arne},
  issn         = {1525-2191},
  language     = {eng},
  number       = {1},
  pages        = {334--341},
  publisher    = {American Society for Investigative Pathology},
  series       = {American Journal of Pathology},
  title        = {Prognostic Significance of Stromal Platelet-Derived Growth Factor beta-Receptor Expression in Human Breast Cancer},
  url          = {http://dx.doi.org/10.2353/ajpath.2009.081030},
  volume       = {175},
  year         = {2009},
}