Association between a Polymorphism of the 5-HT2C Receptor and Weight Loss in Teenage Girls
(2002) In Neuropsychopharmacology 26(6). p.789-793- Abstract
- Receptors of the 5-HT2C subtype are assumed to be involved in the influence of serotonin on food intake. A polymorphism in the coding region of the gene for this receptor, resulting in a cysteine to serine substitution, has been reported. Fifty-seven somatically healthy teenage girls displaying weight loss and 91 normal-weight girls of the same age, all recruited by means of a population-based screening study, were compared with respect to this polymorphism. Subjects in the weight loss group displayed a higher frequency of the serine allele than those in the comparison group (23.7% vs. 7.7%, p = .0001). Seventy-two percent of the weight loss girls fulfilled the diagnostic criteria of anorexia nervosa, whereas 28% did not; when these two... (More)
- Receptors of the 5-HT2C subtype are assumed to be involved in the influence of serotonin on food intake. A polymorphism in the coding region of the gene for this receptor, resulting in a cysteine to serine substitution, has been reported. Fifty-seven somatically healthy teenage girls displaying weight loss and 91 normal-weight girls of the same age, all recruited by means of a population-based screening study, were compared with respect to this polymorphism. Subjects in the weight loss group displayed a higher frequency of the serine allele than those in the comparison group (23.7% vs. 7.7%, p = .0001). Seventy-two percent of the weight loss girls fulfilled the diagnostic criteria of anorexia nervosa, whereas 28% did not; when these two groups were separately analyzed, both differed significantly from controls with respect to serine allele frequency. The results support the notion that the studied gene may be involved in the regulation of food intake in young women. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1464167
- author
- Westberg, Lars ; Bah, Jessica ; Råstam, Maria LU ; Gillberg, Christopher ; Wentz, Elisabet ; Melke, Jonas and Eriksson, Elias
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Anorexia nervosa, Eating disorder, Serotonin, 5-HT2C receptor, Genetics
- in
- Neuropsychopharmacology
- volume
- 26
- issue
- 6
- pages
- 789 - 793
- publisher
- Elsevier
- external identifiers
-
- scopus:0036235909
- ISSN
- 1740-634X
- DOI
- 10.1016/S0893-133X(01)00417-1
- language
- English
- LU publication?
- no
- id
- 918bd6c0-d0e4-4d8a-bc7b-e31133e0637b (old id 1464167)
- date added to LUP
- 2016-04-04 11:20:50
- date last changed
- 2022-01-29 21:41:50
@article{918bd6c0-d0e4-4d8a-bc7b-e31133e0637b, abstract = {{Receptors of the 5-HT2C subtype are assumed to be involved in the influence of serotonin on food intake. A polymorphism in the coding region of the gene for this receptor, resulting in a cysteine to serine substitution, has been reported. Fifty-seven somatically healthy teenage girls displaying weight loss and 91 normal-weight girls of the same age, all recruited by means of a population-based screening study, were compared with respect to this polymorphism. Subjects in the weight loss group displayed a higher frequency of the serine allele than those in the comparison group (23.7% vs. 7.7%, p = .0001). Seventy-two percent of the weight loss girls fulfilled the diagnostic criteria of anorexia nervosa, whereas 28% did not; when these two groups were separately analyzed, both differed significantly from controls with respect to serine allele frequency. The results support the notion that the studied gene may be involved in the regulation of food intake in young women.}}, author = {{Westberg, Lars and Bah, Jessica and Råstam, Maria and Gillberg, Christopher and Wentz, Elisabet and Melke, Jonas and Eriksson, Elias}}, issn = {{1740-634X}}, keywords = {{Anorexia nervosa; Eating disorder; Serotonin; 5-HT2C receptor; Genetics}}, language = {{eng}}, number = {{6}}, pages = {{789--793}}, publisher = {{Elsevier}}, series = {{Neuropsychopharmacology}}, title = {{Association between a Polymorphism of the 5-HT2C Receptor and Weight Loss in Teenage Girls}}, url = {{http://dx.doi.org/10.1016/S0893-133X(01)00417-1}}, doi = {{10.1016/S0893-133X(01)00417-1}}, volume = {{26}}, year = {{2002}}, }