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Overweight in relation to tumour size and axillary lymph node involvement in postmenopausal breast cancer patients-differences between women invited to vs. not invited to mammography in a randomized screening trial.

Olsson, Åsa LU ; Garne, Jens Peter; Tengrup, Ingrid LU ; Zackrisson, Sophia LU and Manjer, Jonas LU (2009) In Cancer Epidemiology 33(1). p.41532-41532
Abstract
OBJECTIVES: Overweight is associated with advanced stage at diagnosis in breast cancer patients. This could be explained by specific tumour characteristics or tumour promoting factors in the obese, but a diagnostic delay could also be of importance. Mammographic screening has caused a change towards diagnosis of less advanced tumours. This study investigates invitation to mammographic screening and the association between overweight and tumour size/axillary lymph node involvement at breast cancer diagnosis in postmenopausal women. METHODS: In 1976 a randomized mammographic screening trial, inviting 50% of all women aged 45-69 was set up in Malmö, Sweden. The present analysis examined overweight (body mass index >or=25) as a determinant... (More)
OBJECTIVES: Overweight is associated with advanced stage at diagnosis in breast cancer patients. This could be explained by specific tumour characteristics or tumour promoting factors in the obese, but a diagnostic delay could also be of importance. Mammographic screening has caused a change towards diagnosis of less advanced tumours. This study investigates invitation to mammographic screening and the association between overweight and tumour size/axillary lymph node involvement at breast cancer diagnosis in postmenopausal women. METHODS: In 1976 a randomized mammographic screening trial, inviting 50% of all women aged 45-69 was set up in Malmö, Sweden. The present analysis examined overweight (body mass index >or=25) as a determinant for large tumours (>20mm) and axillary lymph node involvement in postmenopausal women. These associations were studied separately in patients diagnosed prior to the mammographic screening trial, in invited women and in non-invited subjects (controls). In all, 2478 postmenopausal women were diagnosed with invasive breast cancer in these groups between 1961 and 1991. Logistic regression analysis allowed adjustment for other potential determinants of tumours size and axillary lymph node involvement. RESULTS: In women diagnosed before the onset of the screening trial and in women not invited to mammography in the trial (controls), overweight was positively associated with large tumour size and axillary node involvement. There was no statistically significant association between overweight and these factors in women invited to mammographic screening. CONCLUSION: Invitation to mammographic screening may be particularly important for overweight postmenopausal women in order to detect breast tumours early. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Cancer Epidemiology
volume
33
issue
1
pages
41532 - 41532
publisher
Elsevier
external identifiers
  • wos:000269846400003
  • pmid:19679041
  • scopus:67649844032
ISSN
1877-7821
DOI
10.1016/j.canep.2009.04.008
language
English
LU publication?
yes
id
581ac91c-56ec-4520-af24-e8f07a38841a (old id 1469775)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19679041?dopt=Abstract
date added to LUP
2009-09-08 09:16:53
date last changed
2017-01-01 07:36:38
@article{581ac91c-56ec-4520-af24-e8f07a38841a,
  abstract     = {OBJECTIVES: Overweight is associated with advanced stage at diagnosis in breast cancer patients. This could be explained by specific tumour characteristics or tumour promoting factors in the obese, but a diagnostic delay could also be of importance. Mammographic screening has caused a change towards diagnosis of less advanced tumours. This study investigates invitation to mammographic screening and the association between overweight and tumour size/axillary lymph node involvement at breast cancer diagnosis in postmenopausal women. METHODS: In 1976 a randomized mammographic screening trial, inviting 50% of all women aged 45-69 was set up in Malmö, Sweden. The present analysis examined overweight (body mass index >or=25) as a determinant for large tumours (>20mm) and axillary lymph node involvement in postmenopausal women. These associations were studied separately in patients diagnosed prior to the mammographic screening trial, in invited women and in non-invited subjects (controls). In all, 2478 postmenopausal women were diagnosed with invasive breast cancer in these groups between 1961 and 1991. Logistic regression analysis allowed adjustment for other potential determinants of tumours size and axillary lymph node involvement. RESULTS: In women diagnosed before the onset of the screening trial and in women not invited to mammography in the trial (controls), overweight was positively associated with large tumour size and axillary node involvement. There was no statistically significant association between overweight and these factors in women invited to mammographic screening. CONCLUSION: Invitation to mammographic screening may be particularly important for overweight postmenopausal women in order to detect breast tumours early.},
  author       = {Olsson, Åsa and Garne, Jens Peter and Tengrup, Ingrid and Zackrisson, Sophia and Manjer, Jonas},
  issn         = {1877-7821},
  language     = {eng},
  number       = {1},
  pages        = {41532--41532},
  publisher    = {Elsevier},
  series       = {Cancer Epidemiology},
  title        = {Overweight in relation to tumour size and axillary lymph node involvement in postmenopausal breast cancer patients-differences between women invited to vs. not invited to mammography in a randomized screening trial.},
  url          = {http://dx.doi.org/10.1016/j.canep.2009.04.008},
  volume       = {33},
  year         = {2009},
}