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Carotid Intima-Media Thickness, Systemic Inflammation, and Incidence of Heart Failure Hospitalizations.

Engström, Gunnar LU ; Melander, Olle LU and Hedblad, Bo LU (2009) In Arteriosclerosis, Thrombosis and Vascular Biology 29. p.1691-1695
Abstract
OBJECTIVE: This study explored the relationships between carotid intima-media thickness (IMT), plasma levels of C-reactive protein (CRP), and incidence of heart failure hospitalizations. METHODS AND RESULTS: Men and women from the general population (n=4691), without history of myocardial infarction or stroke, were examined. Incidence of hospitalizations attributable to heart failure was studied over a mean follow-up of 13 years. A total of 75 subjects were hospitalized with a primary diagnosis of heart failure. Adjusted for risk factors, the hazards ratios (95% CI) were 1.00, 0.98 (0.36 to 2.7), 1.9 (0.80 to 4.6), and 2.7 (1.1 to 6.2), respectively, for the 1st, 2nd, 3rd, and 4th quartiles of IMT (P for trend=0.003). The HR associated... (More)
OBJECTIVE: This study explored the relationships between carotid intima-media thickness (IMT), plasma levels of C-reactive protein (CRP), and incidence of heart failure hospitalizations. METHODS AND RESULTS: Men and women from the general population (n=4691), without history of myocardial infarction or stroke, were examined. Incidence of hospitalizations attributable to heart failure was studied over a mean follow-up of 13 years. A total of 75 subjects were hospitalized with a primary diagnosis of heart failure. Adjusted for risk factors, the hazards ratios (95% CI) were 1.00, 0.98 (0.36 to 2.7), 1.9 (0.80 to 4.6), and 2.7 (1.1 to 6.2), respectively, for the 1st, 2nd, 3rd, and 4th quartiles of IMT (P for trend=0.003). The HR associated with CRP levels >/=3 mg/L (versus <1 mg/L) was 2.0 (95% CI: 1.06 to 3.9) after adjustments for risk factors. There was a significant interaction between IMT and CRP on heart failure incidence (P=0.028). Subjects with CRP >/=3 mg/L and IMT in the 4th quartile had an adjusted HR of 3.7 (1.9 to 7.1) compared to those with CRP <3 mg/L and IMT in quartile 1 to 3. CONCLUSIONS: High IMT and high CRP are both independent risk factors for incidence of heart failure requiring hospitalization. The joint exposure to both risk factors substantially increases the risk. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Arteriosclerosis, Thrombosis and Vascular Biology
volume
29
pages
1691 - 1695
publisher
American Heart Association
external identifiers
  • wos:000269848600045
  • pmid:19644052
  • scopus:70349567634
ISSN
1524-4636
DOI
10.1161/ATVBAHA.109.193490
language
English
LU publication?
yes
id
0d77f720-4e9f-4298-b427-abfefe1e1526 (old id 1470219)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19644052?dopt=Abstract
date added to LUP
2009-09-04 10:55:04
date last changed
2017-05-21 04:33:14
@article{0d77f720-4e9f-4298-b427-abfefe1e1526,
  abstract     = {OBJECTIVE: This study explored the relationships between carotid intima-media thickness (IMT), plasma levels of C-reactive protein (CRP), and incidence of heart failure hospitalizations. METHODS AND RESULTS: Men and women from the general population (n=4691), without history of myocardial infarction or stroke, were examined. Incidence of hospitalizations attributable to heart failure was studied over a mean follow-up of 13 years. A total of 75 subjects were hospitalized with a primary diagnosis of heart failure. Adjusted for risk factors, the hazards ratios (95% CI) were 1.00, 0.98 (0.36 to 2.7), 1.9 (0.80 to 4.6), and 2.7 (1.1 to 6.2), respectively, for the 1st, 2nd, 3rd, and 4th quartiles of IMT (P for trend=0.003). The HR associated with CRP levels &gt;/=3 mg/L (versus &lt;1 mg/L) was 2.0 (95% CI: 1.06 to 3.9) after adjustments for risk factors. There was a significant interaction between IMT and CRP on heart failure incidence (P=0.028). Subjects with CRP &gt;/=3 mg/L and IMT in the 4th quartile had an adjusted HR of 3.7 (1.9 to 7.1) compared to those with CRP &lt;3 mg/L and IMT in quartile 1 to 3. CONCLUSIONS: High IMT and high CRP are both independent risk factors for incidence of heart failure requiring hospitalization. The joint exposure to both risk factors substantially increases the risk.},
  author       = {Engström, Gunnar and Melander, Olle and Hedblad, Bo},
  issn         = {1524-4636},
  language     = {eng},
  pages        = {1691--1695},
  publisher    = {American Heart Association},
  series       = {Arteriosclerosis, Thrombosis and Vascular Biology},
  title        = {Carotid Intima-Media Thickness, Systemic Inflammation, and Incidence of Heart Failure Hospitalizations.},
  url          = {http://dx.doi.org/10.1161/ATVBAHA.109.193490},
  volume       = {29},
  year         = {2009},
}