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From sneeze to wheeze: Non-invasive studies on asthma and rhinitis

Aronsson, David LU (2009) In Lund University, Faculty of Medicine Doctoral Dissertation Serie 2009:77.
Abstract
Asthma and allergic rhinitis are diseases that cause major disability and illness in all ethnic groups and ages. It is well established that allergic rhinitis and asthma are closely linked entities and more than 75 % of the patients with asthma reports concomitant rhinitis. Asthma is also closely associated to bronchial hyperresponsiveness, and a large part of patients with rhinitis alone show a reactive pattern in bronchial provocation tests, even though they have no symptoms of clinical asthma. The fact that patients can react with airway obstruction to bronchial challenge, which is a hallmark of asthma, without experiencing symptoms is curious and could possible be explained by difference in degree and/or geographical distribution of... (More)
Asthma and allergic rhinitis are diseases that cause major disability and illness in all ethnic groups and ages. It is well established that allergic rhinitis and asthma are closely linked entities and more than 75 % of the patients with asthma reports concomitant rhinitis. Asthma is also closely associated to bronchial hyperresponsiveness, and a large part of patients with rhinitis alone show a reactive pattern in bronchial provocation tests, even though they have no symptoms of clinical asthma. The fact that patients can react with airway obstruction to bronchial challenge, which is a hallmark of asthma, without experiencing symptoms is curious and could possible be explained by difference in degree and/or geographical distribution of inflammation. In this thesis I wanted to investigate the distribution of inflammation and obstruction in asthmatics compared to patients with allergic rhinitis with or without bronchial hyperresponsiveness. We found that patients with asthma had a greater perception of the obstruction induced during methacholine challenge test compared to patients with rhinitis and bronchial hyperresponsiveness. By using non-invasive techniques such as induced sputum, exhaled nitric oxide and impulse oscillometry in addition to bronchial provocation tests we found signs indicating a higher degree of peripheral airway involvement in the asthmatic group. The transition from allergic rhinitis to clinical asthma is probably a gradual one, with bronchial hyperresponsiveness possibly representing an intermediate step. The geographical distribution of the airway inflammation seems to be a key element in the progress of the airway disease. (Less)
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author
supervisor
opponent
  • Ass Prof Backer, Vibeke, Department of Respiratory Medicine L, Bispebjerg Hospital, Copenhagen
organization
publishing date
type
Thesis
publication status
published
subject
keywords
airway inflammation, united airways, airway hyperresponsiveness, asthma, allergíc rhinitis
in
Lund University, Faculty of Medicine Doctoral Dissertation Serie
volume
2009:77
pages
146 pages
publisher
Lund University, Faculty of Medicine
defense location
Föreläsningssal F1, Blocket, USiL
defense date
2009-10-02 09:00
ISSN
1652-8220
ISBN
978-91-86253-65-3
language
English
LU publication?
yes
id
7a3afa74-3eaf-477e-9be9-a09d9e3ae7d1 (old id 1473976)
date added to LUP
2009-09-21 09:54:52
date last changed
2016-09-19 08:44:48
@phdthesis{7a3afa74-3eaf-477e-9be9-a09d9e3ae7d1,
  abstract     = {Asthma and allergic rhinitis are diseases that cause major disability and illness in all ethnic groups and ages. It is well established that allergic rhinitis and asthma are closely linked entities and more than 75 % of the patients with asthma reports concomitant rhinitis. Asthma is also closely associated to bronchial hyperresponsiveness, and a large part of patients with rhinitis alone show a reactive pattern in bronchial provocation tests, even though they have no symptoms of clinical asthma. The fact that patients can react with airway obstruction to bronchial challenge, which is a hallmark of asthma, without experiencing symptoms is curious and could possible be explained by difference in degree and/or geographical distribution of inflammation. In this thesis I wanted to investigate the distribution of inflammation and obstruction in asthmatics compared to patients with allergic rhinitis with or without bronchial hyperresponsiveness. We found that patients with asthma had a greater perception of the obstruction induced during methacholine challenge test compared to patients with rhinitis and bronchial hyperresponsiveness. By using non-invasive techniques such as induced sputum, exhaled nitric oxide and impulse oscillometry in addition to bronchial provocation tests we found signs indicating a higher degree of peripheral airway involvement in the asthmatic group. The transition from allergic rhinitis to clinical asthma is probably a gradual one, with bronchial hyperresponsiveness possibly representing an intermediate step. The geographical distribution of the airway inflammation seems to be a key element in the progress of the airway disease.},
  author       = {Aronsson, David},
  isbn         = {978-91-86253-65-3},
  issn         = {1652-8220},
  keyword      = {airway inflammation,united airways,airway hyperresponsiveness,asthma,allergíc rhinitis},
  language     = {eng},
  pages        = {146},
  publisher    = {Lund University, Faculty of Medicine},
  school       = {Lund University},
  series       = {Lund University, Faculty of Medicine Doctoral Dissertation Serie},
  title        = {From sneeze to wheeze: Non-invasive studies on asthma and rhinitis},
  volume       = {2009:77},
  year         = {2009},
}