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New vanadium oxido complexes with potential biological activity

Nilsson, Jessica LU (2009)
Abstract
Several biological aspects of vanadium are known and even though it has not been proven to be an essential metal for humans, it might have implication as a drug against the disease diabetes mellitus. However, undesired side effect as a result of the toxicity of vanadium must be reduced. Studies have shown that the toxicity is decreased by coordination of the metal to organic ligands. This thesis presents several new oxidovanadium complexes that have been evaluated for their ability to mimic certain aspects of insulin signaling. The complexes are NXOY- or O4-coordinated with variable lipophilicity and/or stability. Stable complexes of tetra- and tridentate ligands, viz. [V(IV)O(bp-O)HSO4], [V(IV)O(bp-OH)Cl2] (bp-OH =... (More)
Several biological aspects of vanadium are known and even though it has not been proven to be an essential metal for humans, it might have implication as a drug against the disease diabetes mellitus. However, undesired side effect as a result of the toxicity of vanadium must be reduced. Studies have shown that the toxicity is decreased by coordination of the metal to organic ligands. This thesis presents several new oxidovanadium complexes that have been evaluated for their ability to mimic certain aspects of insulin signaling. The complexes are NXOY- or O4-coordinated with variable lipophilicity and/or stability. Stable complexes of tetra- and tridentate ligands, viz. [V(IV)O(bp-O)HSO4], [V(IV)O(bp-OH)Cl2] (bp-OH = bis(pyridylmethyl)-o-hydroxybenzylamine) and [{(papy)(VO)}2µ-O)] (H2papy = N-(2-hydroxybenzyl)-N-(2-picolyl)-glycine), as well as the lipophilic complex [V(V)O(tBuLNO)2(CH3O)] (tBuLNOH = di(4-tert-butylphenyl)-2-pyridylcarbinol), show less insulin-mimetic effect than the benchmark VOSO4 salt. However, two new complexes, viz. [(glysal)VO(H2O)] (H2glysal = N-(2-hydroxybenzyl)glycine) and [(salam)2VO] (Hsalam = salicylamide), did show effects comparable to VOSO4. Additional oxidovanadium complexes that were not subjected to biological testing, viz. ([bp-OH)V(V)O(O2)]+ and [V(IV)O(tBuLNO)2], as well as one new decavanadate structure, [Na(H2O)4]6[V10O28].2H2O, are also presented. (Less)
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author
supervisor
opponent
  • Prof. Kabanos, Themistoklis, University of Ioannina, Department of Chemistry, Section of Inorganic and Analytical Chemistry
organization
publishing date
type
Thesis
publication status
published
subject
defense location
Chemical centre, lecture hall C
defense date
2009-10-09 10:30
ISBN
978-91-7422-230-2
language
English
LU publication?
yes
id
aed64edb-396d-4d60-986d-bddbfdd1b000 (old id 1474213)
date added to LUP
2009-09-15 13:03:18
date last changed
2016-09-19 08:45:17
@phdthesis{aed64edb-396d-4d60-986d-bddbfdd1b000,
  abstract     = {Several biological aspects of vanadium are known and even though it has not been proven to be an essential metal for humans, it might have implication as a drug against the disease diabetes mellitus. However, undesired side effect as a result of the toxicity of vanadium must be reduced. Studies have shown that the toxicity is decreased by coordination of the metal to organic ligands. This thesis presents several new oxidovanadium complexes that have been evaluated for their ability to mimic certain aspects of insulin signaling. The complexes are NXOY- or O4-coordinated with variable lipophilicity and/or stability. Stable complexes of tetra- and tridentate ligands, viz. [V(IV)O(bp-O)HSO4], [V(IV)O(bp-OH)Cl2] (bp-OH = bis(pyridylmethyl)-o-hydroxybenzylamine) and [{(papy)(VO)}2µ-O)] (H2papy = N-(2-hydroxybenzyl)-N-(2-picolyl)-glycine), as well as the lipophilic complex [V(V)O(tBuLNO)2(CH3O)] (tBuLNOH = di(4-tert-butylphenyl)-2-pyridylcarbinol), show less insulin-mimetic effect than the benchmark VOSO4 salt. However, two new complexes, viz. [(glysal)VO(H2O)] (H2glysal = N-(2-hydroxybenzyl)glycine) and [(salam)2VO] (Hsalam = salicylamide), did show effects comparable to VOSO4. Additional oxidovanadium complexes that were not subjected to biological testing, viz. ([bp-OH)V(V)O(O2)]+ and [V(IV)O(tBuLNO)2], as well as one new decavanadate structure, [Na(H2O)4]6[V10O28].2H2O, are also presented.},
  author       = {Nilsson, Jessica},
  isbn         = {978-91-7422-230-2},
  language     = {eng},
  school       = {Lund University},
  title        = {New vanadium oxido complexes with potential biological activity},
  year         = {2009},
}