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Tissue responses to novel tissue engineering biodegradable cryogel scaffolds: An animal model

Bolgen, Nimet; Vargel, Ibrahim; Korkusuz, Petek; Guzel, Elif; Plieva, Fatima; Galaev, Igor LU ; Matiasson, Bo and Piskin, Erhan (2009) In Journal of Biomedical Materials Research. Part A 91A(1). p.60-68
Abstract
Biodegradable macroporous cryogels with highly open and interconnected pore structures were produced from dextran modified with oligo L-lactide bearing hydroxyethylmethacrylate (HEMA) end groups in moderately frozen solutions. Tissue responses to these novel scaffolds were evaluated in rats after dorsal subcutaneous implantation, iliac submuscular implantation, auricular implantation, or in calvarial defect model. In no case, either necrosis or foreign body reaction was observed during histological studies. The cryogel scaffolds integrated with the surrounding tissue and the formation of a new tissue were accompanied with significant ingrowth of connective tissue cells and new blood vessels into the cryogel. The tissue responses were... (More)
Biodegradable macroporous cryogels with highly open and interconnected pore structures were produced from dextran modified with oligo L-lactide bearing hydroxyethylmethacrylate (HEMA) end groups in moderately frozen solutions. Tissue responses to these novel scaffolds were evaluated in rats after dorsal subcutaneous implantation, iliac submuscular implantation, auricular implantation, or in calvarial defect model. In no case, either necrosis or foreign body reaction was observed during histological studies. The cryogel scaffolds integrated with the surrounding tissue and the formation of a new tissue were accompanied with significant ingrowth of connective tissue cells and new blood vessels into the cryogel. The tissue responses were significantly lower in auricular and calvarial implantations when compared with the subcutanous and the submuscular implantations. The degradation of the scaffold was slower in bone comparing to soft tissues. The biodegradable cryogels are highly biocompatible and combine extraordinary properties including having soft and elastic nature, open porous structure, and very rapid and controllable swelling. Therefore, the cryogels could be promising candidates for further clinical applications in tissue regeneration. (C) 2008 Wiley Periodicals, Inc. J Biomed Mater Res 91 A: 60-68, 2009 (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
HEMA-L-lactide-dextran, biodegradable, tissue-engineering scaffolds, cryogels, animal model, tissue reponses
in
Journal of Biomedical Materials Research. Part A
volume
91A
issue
1
pages
60 - 68
publisher
John Wiley & Sons
external identifiers
  • wos:000269627700007
  • scopus:70349113963
ISSN
1552-4965
DOI
10.1002/jbm.a.32193
language
English
LU publication?
yes
id
4a067f6a-7a74-4b87-9046-d450790e0dde (old id 1475171)
date added to LUP
2009-10-01 16:07:27
date last changed
2017-11-19 03:30:18
@article{4a067f6a-7a74-4b87-9046-d450790e0dde,
  abstract     = {Biodegradable macroporous cryogels with highly open and interconnected pore structures were produced from dextran modified with oligo L-lactide bearing hydroxyethylmethacrylate (HEMA) end groups in moderately frozen solutions. Tissue responses to these novel scaffolds were evaluated in rats after dorsal subcutaneous implantation, iliac submuscular implantation, auricular implantation, or in calvarial defect model. In no case, either necrosis or foreign body reaction was observed during histological studies. The cryogel scaffolds integrated with the surrounding tissue and the formation of a new tissue were accompanied with significant ingrowth of connective tissue cells and new blood vessels into the cryogel. The tissue responses were significantly lower in auricular and calvarial implantations when compared with the subcutanous and the submuscular implantations. The degradation of the scaffold was slower in bone comparing to soft tissues. The biodegradable cryogels are highly biocompatible and combine extraordinary properties including having soft and elastic nature, open porous structure, and very rapid and controllable swelling. Therefore, the cryogels could be promising candidates for further clinical applications in tissue regeneration. (C) 2008 Wiley Periodicals, Inc. J Biomed Mater Res 91 A: 60-68, 2009},
  author       = {Bolgen, Nimet and Vargel, Ibrahim and Korkusuz, Petek and Guzel, Elif and Plieva, Fatima and Galaev, Igor and Matiasson, Bo and Piskin, Erhan},
  issn         = {1552-4965},
  keyword      = {HEMA-L-lactide-dextran,biodegradable,tissue-engineering scaffolds,cryogels,animal model,tissue reponses},
  language     = {eng},
  number       = {1},
  pages        = {60--68},
  publisher    = {John Wiley & Sons},
  series       = {Journal of Biomedical Materials Research. Part A},
  title        = {Tissue responses to novel tissue engineering biodegradable cryogel scaffolds: An animal model},
  url          = {http://dx.doi.org/10.1002/jbm.a.32193},
  volume       = {91A},
  year         = {2009},
}