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Genetic Variation in Brain-Derived Neurotrophic Factor Is Associated with Serotonin Transporter but Not Serotonin-1A Receptor Availability in Men

Henningsson, Susanne; Borg, Jacqueline; Lundberg, Johan; Bah, Jessica; Lindström, Mats LU ; Ryding, Erik LU ; Jovanovic, Hristina; Saijo, Tomoyuki; Inoue, Makoto and Rosén, Ingmar LU , et al. (2009) In Biological Psychiatry 66(5). p.477-485
Abstract
Background: The serotonergic system, including the serotonin transporter (5-HTT), which is the target of many antidepressants, seems to be influenced by brain-derived neurotrophic factor (BDNF). Methods: Positron emission tomography (PET) was used to address, in 25 and 53 healthy volunteers, respectively, the possible association between six polymorphisms in the gene encoding BDNF and the availability of two proteins expressed by serotonergic neurons: the 5-HTT, measured with the radioligand [C-11]MADAM, and the serotonin-1A (5-HT1A) receptor, measured with [C-11]WAY-100635. Results: Several single nucleotide polymorphisms were associated with [C-11]MADAM binding potential (BP) in most brain regions, male carriers of the valine/valine... (More)
Background: The serotonergic system, including the serotonin transporter (5-HTT), which is the target of many antidepressants, seems to be influenced by brain-derived neurotrophic factor (BDNF). Methods: Positron emission tomography (PET) was used to address, in 25 and 53 healthy volunteers, respectively, the possible association between six polymorphisms in the gene encoding BDNF and the availability of two proteins expressed by serotonergic neurons: the 5-HTT, measured with the radioligand [C-11]MADAM, and the serotonin-1A (5-HT1A) receptor, measured with [C-11]WAY-100635. Results: Several single nucleotide polymorphisms were associated with [C-11]MADAM binding potential (BP) in most brain regions, male carriers of the valine/valine genotype of the Val66Met polymorphism displaying higher availability. Effect sizes ranged from a 50% to a threefold increase. In contrast, there was no association for [C-11]WAY-100635 BP. The observation that BDNF polymorphisms were associated with 5-HTT availability could be partly replicated in an independent population comprising nine male suicide attempters and nine matched control subjects, in which transporter availability had been measured with single photon emission computed tomography with I-123-beta-CIT as ligand. Conclusions: Our results suggest that genetic variation in BDNF influences 5-HTT but not 5-HT1A receptor density in the human brain. (Less)
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Contribution to journal
publication status
published
subject
keywords
SPECT, serotonin transporter, serotonin, PET, BDNF, imaging
in
Biological Psychiatry
volume
66
issue
5
pages
477 - 485
publisher
Society of Biological Psychiatry Published by Elsevier Inc.
external identifiers
  • wos:000269330900010
  • scopus:68049127796
ISSN
0006-3223
DOI
10.1016/j.biopsych.2009.04.009
language
English
LU publication?
yes
id
f781fd19-240f-4d6a-b7ff-ebf00017302a (old id 1476777)
date added to LUP
2009-09-25 08:53:48
date last changed
2017-05-14 03:42:31
@article{f781fd19-240f-4d6a-b7ff-ebf00017302a,
  abstract     = {Background: The serotonergic system, including the serotonin transporter (5-HTT), which is the target of many antidepressants, seems to be influenced by brain-derived neurotrophic factor (BDNF). Methods: Positron emission tomography (PET) was used to address, in 25 and 53 healthy volunteers, respectively, the possible association between six polymorphisms in the gene encoding BDNF and the availability of two proteins expressed by serotonergic neurons: the 5-HTT, measured with the radioligand [C-11]MADAM, and the serotonin-1A (5-HT1A) receptor, measured with [C-11]WAY-100635. Results: Several single nucleotide polymorphisms were associated with [C-11]MADAM binding potential (BP) in most brain regions, male carriers of the valine/valine genotype of the Val66Met polymorphism displaying higher availability. Effect sizes ranged from a 50% to a threefold increase. In contrast, there was no association for [C-11]WAY-100635 BP. The observation that BDNF polymorphisms were associated with 5-HTT availability could be partly replicated in an independent population comprising nine male suicide attempters and nine matched control subjects, in which transporter availability had been measured with single photon emission computed tomography with I-123-beta-CIT as ligand. Conclusions: Our results suggest that genetic variation in BDNF influences 5-HTT but not 5-HT1A receptor density in the human brain.},
  author       = {Henningsson, Susanne and Borg, Jacqueline and Lundberg, Johan and Bah, Jessica and Lindström, Mats and Ryding, Erik and Jovanovic, Hristina and Saijo, Tomoyuki and Inoue, Makoto and Rosén, Ingmar and Träskman Bendz, Lil and Farde, Lars and Eriksson, Elias},
  issn         = {0006-3223},
  keyword      = {SPECT,serotonin transporter,serotonin,PET,BDNF,imaging},
  language     = {eng},
  number       = {5},
  pages        = {477--485},
  publisher    = {Society of Biological Psychiatry Published by Elsevier Inc.},
  series       = {Biological Psychiatry},
  title        = {Genetic Variation in Brain-Derived Neurotrophic Factor Is Associated with Serotonin Transporter but Not Serotonin-1A Receptor Availability in Men},
  url          = {http://dx.doi.org/10.1016/j.biopsych.2009.04.009},
  volume       = {66},
  year         = {2009},
}