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Potential roles for the small leucine-rich proteoglycans biglycan and fibromodulin in ectopic ossification of tendon induced by exercise and in modulating rotarod performance

Kilts, T.; Ameye, L.; Syed-Picard, F.; Ono, M.; Berendsen, A. D.; Oldberg, Åke LU ; Heegaard, A. -M.; Bi, Y. and Young, M. F. (2009) In Scandinavian Journal of Medicine & Science in Sports 19(4). p.536-546
Abstract
We present a detailed comparison of ectopic ossification (EO) found in tendons of biglycan (Bgn), fibromodulin (Fmod) single and double Bgn/Fmod-deficient (DKO) mice with aging. At 3 months, Fmod KO, Bgn KO and DKO displayed torn cruciate ligaments and EO in their quadriceps tendon, menisci and cruciate and patellar ligaments. The phenotype was the least severe in the Fmod KO, intermediate in the Bgn KO and the most severe in the DKO. This condition progressed with age in all three mouse strains and resulted in the development of large supernumerary sesmoid bones. To determine the role of exercise in the extent of EO, we subjected normal and DKO mice to a treadmill exercise 3 days a week for 4 weeks. In contrast to previous findings using... (More)
We present a detailed comparison of ectopic ossification (EO) found in tendons of biglycan (Bgn), fibromodulin (Fmod) single and double Bgn/Fmod-deficient (DKO) mice with aging. At 3 months, Fmod KO, Bgn KO and DKO displayed torn cruciate ligaments and EO in their quadriceps tendon, menisci and cruciate and patellar ligaments. The phenotype was the least severe in the Fmod KO, intermediate in the Bgn KO and the most severe in the DKO. This condition progressed with age in all three mouse strains and resulted in the development of large supernumerary sesmoid bones. To determine the role of exercise in the extent of EO, we subjected normal and DKO mice to a treadmill exercise 3 days a week for 4 weeks. In contrast to previous findings using more rigorous exercise regimes, the EO in moderately exercised DKO was decreased compared with unexercised DKO mice. Finally, DKO and Bgn KO mice tested using a rotarod showed a reduced ability to maintain their grip on a rotating cylinder compared with wild-type controls. In summary, we show (1) a detailed description of EO formed by Bgn, Fmod or combined depletion, (2) the role of exercise in modulating EO and (3) that Bgn and Fmod are critical in controlling motor function. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
ectopic ossification, extracellular matrix, tendon, treadmill, rotarod
in
Scandinavian Journal of Medicine & Science in Sports
volume
19
issue
4
pages
536 - 546
publisher
Wiley-Blackwell
external identifiers
  • wos:000269192000010
  • scopus:69149095063
ISSN
1600-0838
DOI
10.1111/j.1600-0838.2009.00909.x
language
English
LU publication?
yes
id
e8b29aee-6309-437a-91d8-1e75c066310f (old id 1476867)
date added to LUP
2009-09-28 11:27:25
date last changed
2017-10-22 04:25:55
@article{e8b29aee-6309-437a-91d8-1e75c066310f,
  abstract     = {We present a detailed comparison of ectopic ossification (EO) found in tendons of biglycan (Bgn), fibromodulin (Fmod) single and double Bgn/Fmod-deficient (DKO) mice with aging. At 3 months, Fmod KO, Bgn KO and DKO displayed torn cruciate ligaments and EO in their quadriceps tendon, menisci and cruciate and patellar ligaments. The phenotype was the least severe in the Fmod KO, intermediate in the Bgn KO and the most severe in the DKO. This condition progressed with age in all three mouse strains and resulted in the development of large supernumerary sesmoid bones. To determine the role of exercise in the extent of EO, we subjected normal and DKO mice to a treadmill exercise 3 days a week for 4 weeks. In contrast to previous findings using more rigorous exercise regimes, the EO in moderately exercised DKO was decreased compared with unexercised DKO mice. Finally, DKO and Bgn KO mice tested using a rotarod showed a reduced ability to maintain their grip on a rotating cylinder compared with wild-type controls. In summary, we show (1) a detailed description of EO formed by Bgn, Fmod or combined depletion, (2) the role of exercise in modulating EO and (3) that Bgn and Fmod are critical in controlling motor function.},
  author       = {Kilts, T. and Ameye, L. and Syed-Picard, F. and Ono, M. and Berendsen, A. D. and Oldberg, Åke and Heegaard, A. -M. and Bi, Y. and Young, M. F.},
  issn         = {1600-0838},
  keyword      = {ectopic ossification,extracellular matrix,tendon,treadmill,rotarod},
  language     = {eng},
  number       = {4},
  pages        = {536--546},
  publisher    = {Wiley-Blackwell},
  series       = {Scandinavian Journal of Medicine & Science in Sports},
  title        = {Potential roles for the small leucine-rich proteoglycans biglycan and fibromodulin in ectopic ossification of tendon induced by exercise and in modulating rotarod performance},
  url          = {http://dx.doi.org/10.1111/j.1600-0838.2009.00909.x},
  volume       = {19},
  year         = {2009},
}