Advanced

The Modern RNP World of Eukaryotes

Collins, Lesley J.; Kurland, Charles LU ; Biggs, Patrick and Penny, David (2009) In Journal of Heredity 100(5). p.597-604
Abstract
Eukaryote gene expression is mediated by a cascade of RNA functions that regulate, process, store, transport, and translate RNA transcripts. The RNA network that promotes this cascade depends on a large cohort of proteins that partner RNAs; thus, the modern RNA world of eukaryotes is really a ribonucleoprotein (RNP) world. Features of this "RNP infrastructure" can be related to the high cytosolic density of macromolecules and the large size of eukaryote cells. Because of the densely packed cytosol or nucleoplasm (with its severe restriction on diffusion of macromolecules), partitioning of the eukaryote cell into functionally specialized compartments is essential for efficiency. This necessitates the association of RNA and protein into... (More)
Eukaryote gene expression is mediated by a cascade of RNA functions that regulate, process, store, transport, and translate RNA transcripts. The RNA network that promotes this cascade depends on a large cohort of proteins that partner RNAs; thus, the modern RNA world of eukaryotes is really a ribonucleoprotein (RNP) world. Features of this "RNP infrastructure" can be related to the high cytosolic density of macromolecules and the large size of eukaryote cells. Because of the densely packed cytosol or nucleoplasm (with its severe restriction on diffusion of macromolecules), partitioning of the eukaryote cell into functionally specialized compartments is essential for efficiency. This necessitates the association of RNA and protein into large RNP complexes including ribosomes and spliceosomes. This is well illustrated by the ubiquitous spliceosome for which most components are conserved throughout eukaryotes and which interacts with other RNP-based machineries. The complexes involved in gene processing in modern eukaryotes have broad phylogenetic distributions suggesting that the common ancestor of extant eukaryotes had a fully evolved RNP network. Thus, the eukaryote genome may be uniquely informative about the transition from an earlier RNA genome world to the modern DNA genome world. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
RNA world, RNA infrastructure, molecular evolution, origin of eukaryotes
in
Journal of Heredity
volume
100
issue
5
pages
597 - 604
publisher
Oxford University Press
external identifiers
  • wos:000269206800011
  • scopus:69249215256
ISSN
0022-1503
DOI
10.1093/jhered/esp064
language
English
LU publication?
yes
id
0e9c7853-79b0-4ee9-91ab-546cb2ccf67a (old id 1477018)
date added to LUP
2009-09-24 10:56:22
date last changed
2017-01-01 04:39:10
@article{0e9c7853-79b0-4ee9-91ab-546cb2ccf67a,
  abstract     = {Eukaryote gene expression is mediated by a cascade of RNA functions that regulate, process, store, transport, and translate RNA transcripts. The RNA network that promotes this cascade depends on a large cohort of proteins that partner RNAs; thus, the modern RNA world of eukaryotes is really a ribonucleoprotein (RNP) world. Features of this "RNP infrastructure" can be related to the high cytosolic density of macromolecules and the large size of eukaryote cells. Because of the densely packed cytosol or nucleoplasm (with its severe restriction on diffusion of macromolecules), partitioning of the eukaryote cell into functionally specialized compartments is essential for efficiency. This necessitates the association of RNA and protein into large RNP complexes including ribosomes and spliceosomes. This is well illustrated by the ubiquitous spliceosome for which most components are conserved throughout eukaryotes and which interacts with other RNP-based machineries. The complexes involved in gene processing in modern eukaryotes have broad phylogenetic distributions suggesting that the common ancestor of extant eukaryotes had a fully evolved RNP network. Thus, the eukaryote genome may be uniquely informative about the transition from an earlier RNA genome world to the modern DNA genome world.},
  author       = {Collins, Lesley J. and Kurland, Charles and Biggs, Patrick and Penny, David},
  issn         = {0022-1503},
  keyword      = {RNA world,RNA infrastructure,molecular evolution,origin of eukaryotes},
  language     = {eng},
  number       = {5},
  pages        = {597--604},
  publisher    = {Oxford University Press},
  series       = {Journal of Heredity},
  title        = {The Modern RNP World of Eukaryotes},
  url          = {http://dx.doi.org/10.1093/jhered/esp064},
  volume       = {100},
  year         = {2009},
}