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Leukocyte Count and Incidence of Hospitalizations Due to Heart Failure

Engström, Gunnar LU ; Melander, Olle LU and Hedblad, Bo LU (2009) In Circulation Heart Failure 2(3). p.217-222
Abstract
Background-Leukocyte concentration in blood is a classical marker of systemic inflammation. Whether high leukocyte counts are associated with incidence of heart failure (HF) is unknown. This population-based study explored whether the leukocyte concentrations were associated with incidence of hospitalizations due to HF. Methods and results-Leukocyte counts were measured in 16 940 men from the general population (mean age 44 years) without history of myocardial infarction or stroke. Incidence of hospitalizations due to HF (primary diagnosis) was monitored over 23 years of follow-up, in relation to quartiles of leukocytes. Subjects with myocardial infarction during follow-up were censored in the main analysis. During the follow-up, 436 men... (More)
Background-Leukocyte concentration in blood is a classical marker of systemic inflammation. Whether high leukocyte counts are associated with incidence of heart failure (HF) is unknown. This population-based study explored whether the leukocyte concentrations were associated with incidence of hospitalizations due to HF. Methods and results-Leukocyte counts were measured in 16 940 men from the general population (mean age 44 years) without history of myocardial infarction or stroke. Incidence of hospitalizations due to HF (primary diagnosis) was monitored over 23 years of follow-up, in relation to quartiles of leukocytes. Subjects with myocardial infarction during follow-up were censored in the main analysis. During the follow-up, 436 men were hospitalized due to HF. Incidence of HF hospitalizations was increased in men with high leukocyte counts. After adjustments for confounding factors, the adjusted hazards ratio (HR, 95% CI) for HF hospitalization was 1.00 (reference), 1.26 (0.93 to 1.7), 1.24 (0.91 to 1.7), and 1.73 (1.3 to 2.3), respectively, for men with leukocytes in the 1st, 2nd, 3rd, and 4th (highest) quartiles (trend, P<0.001). This relationship was consistent in smokers and nonsmokers and in men with and without hypertension, respectively. Conclusion-High leukocyte counts in middle-aged men were associated with increased long-term incidence of HF hospitalizations. (Circ Heart Fail. 2009;2:217-222.) (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
leukocytes, inflammation, heart failure, epidemiology
in
Circulation Heart Failure
volume
2
issue
3
pages
217 - 222
publisher
American Heart Association
external identifiers
  • wos:000269161600010
  • pmid:19808343
  • scopus:70349563837
ISSN
1941-3297
DOI
10.1161/CIRCHEARTFAILURE.108.827071
language
English
LU publication?
yes
id
cbec4e76-5560-4b7a-9d0a-700f7d32b7a6 (old id 1477060)
date added to LUP
2009-09-23 15:55:30
date last changed
2017-12-10 03:38:58
@article{cbec4e76-5560-4b7a-9d0a-700f7d32b7a6,
  abstract     = {Background-Leukocyte concentration in blood is a classical marker of systemic inflammation. Whether high leukocyte counts are associated with incidence of heart failure (HF) is unknown. This population-based study explored whether the leukocyte concentrations were associated with incidence of hospitalizations due to HF. Methods and results-Leukocyte counts were measured in 16 940 men from the general population (mean age 44 years) without history of myocardial infarction or stroke. Incidence of hospitalizations due to HF (primary diagnosis) was monitored over 23 years of follow-up, in relation to quartiles of leukocytes. Subjects with myocardial infarction during follow-up were censored in the main analysis. During the follow-up, 436 men were hospitalized due to HF. Incidence of HF hospitalizations was increased in men with high leukocyte counts. After adjustments for confounding factors, the adjusted hazards ratio (HR, 95% CI) for HF hospitalization was 1.00 (reference), 1.26 (0.93 to 1.7), 1.24 (0.91 to 1.7), and 1.73 (1.3 to 2.3), respectively, for men with leukocytes in the 1st, 2nd, 3rd, and 4th (highest) quartiles (trend, P&lt;0.001). This relationship was consistent in smokers and nonsmokers and in men with and without hypertension, respectively. Conclusion-High leukocyte counts in middle-aged men were associated with increased long-term incidence of HF hospitalizations. (Circ Heart Fail. 2009;2:217-222.)},
  author       = {Engström, Gunnar and Melander, Olle and Hedblad, Bo},
  issn         = {1941-3297},
  keyword      = {leukocytes,inflammation,heart failure,epidemiology},
  language     = {eng},
  number       = {3},
  pages        = {217--222},
  publisher    = {American Heart Association},
  series       = {Circulation Heart Failure},
  title        = {Leukocyte Count and Incidence of Hospitalizations Due to Heart Failure},
  url          = {http://dx.doi.org/10.1161/CIRCHEARTFAILURE.108.827071},
  volume       = {2},
  year         = {2009},
}