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Ante mortem diagnosis of amoebic encephalitis in a haematopoietic stem cell transplanted patient

Abd, Hadi; Saeed, Amir; Jalal, Sha; Békássy, Albert LU and Sandstrom, Gunnar (2009) In Scandinavian Journal of Infectious Diseases 41(8). p.619-622
Abstract
Acanthamoeba species are widely distributed free-living amoebae showing an increased role as human pathogens causing encephalitis, keratitis, pneumonitis and dermatitis. A haematopoietic stem cell transplanted (HSCT) patient developed purulent meningitis while awaiting regrafting. The meningitis was thought to be an endogenous infection arising from the mucous membranes primarily involving the cervicofacial regions, probably due to haematogenous spread facilitated by surgery. We diagnosed a fatal case of granulomatous amoebic encephalitis caused by Acanthamoeba castellanii by direct microscopy of a cerebrospinal fluid sample (CSF), Acanthamoeba cultivation, Giemsa staining, polymerase chain reaction and sequencing.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Scandinavian Journal of Infectious Diseases
volume
41
issue
8
pages
619 - 622
publisher
Informa Healthcare
external identifiers
  • wos:000268933400012
  • scopus:70849135973
ISSN
1651-1980
DOI
10.1080/00365540903015117
language
English
LU publication?
yes
id
351d856b-be4b-41a8-9e67-df64a3d2d15a (old id 1477136)
date added to LUP
2009-09-23 15:32:50
date last changed
2017-12-10 04:21:22
@misc{351d856b-be4b-41a8-9e67-df64a3d2d15a,
  abstract     = {Acanthamoeba species are widely distributed free-living amoebae showing an increased role as human pathogens causing encephalitis, keratitis, pneumonitis and dermatitis. A haematopoietic stem cell transplanted (HSCT) patient developed purulent meningitis while awaiting regrafting. The meningitis was thought to be an endogenous infection arising from the mucous membranes primarily involving the cervicofacial regions, probably due to haematogenous spread facilitated by surgery. We diagnosed a fatal case of granulomatous amoebic encephalitis caused by Acanthamoeba castellanii by direct microscopy of a cerebrospinal fluid sample (CSF), Acanthamoeba cultivation, Giemsa staining, polymerase chain reaction and sequencing.},
  author       = {Abd, Hadi and Saeed, Amir and Jalal, Sha and Békássy, Albert and Sandstrom, Gunnar},
  issn         = {1651-1980},
  language     = {eng},
  number       = {8},
  pages        = {619--622},
  publisher    = {Informa Healthcare},
  series       = {Scandinavian Journal of Infectious Diseases},
  title        = {Ante mortem diagnosis of amoebic encephalitis in a haematopoietic stem cell transplanted patient},
  url          = {http://dx.doi.org/10.1080/00365540903015117},
  volume       = {41},
  year         = {2009},
}