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Fast multiecho balanced SSFP metabolite mapping of H-1 and hyperpolarized C-13 compounds

Leupold, Jochen; Månsson, Sven LU ; Petersson, J. Stefan; Hennig, Juergen and Wieben, Oliver (2009) In Magma 22(4). p.251-256
Abstract
To investigate the feasibility of multiecho balanced steady-state free precession (bSSFP)-based fast chemical shift mapping hyperpolarized C-13 metabolites. The overall goal was to reduce total imaging time and to increase spatial resolution compared to common chemical shift imaging (CSI). A multiecho bSSFP sequence in combination with an iterative reconstruction algorithm was implemented. H-1 experiments were performed on phantoms and on a human volunteer in order to investigate the feasibility of the method on a system with metabolite maps that are known beforehand. C-13 experiments were performed in vivo on pigs, where CSI images were acquired also for comparison. Chemical shift images of three and four distinct H-1 resonance... (More)
To investigate the feasibility of multiecho balanced steady-state free precession (bSSFP)-based fast chemical shift mapping hyperpolarized C-13 metabolites. The overall goal was to reduce total imaging time and to increase spatial resolution compared to common chemical shift imaging (CSI). A multiecho bSSFP sequence in combination with an iterative reconstruction algorithm was implemented. H-1 experiments were performed on phantoms and on a human volunteer in order to investigate the feasibility of the method on a system with metabolite maps that are known beforehand. C-13 experiments were performed in vivo on pigs, where CSI images were acquired also for comparison. Chemical shift images of three and four distinct H-1 resonance frequencies as well as chemical shift images of up to five hyperpolarized C-13 metabolites were successfully obtained. Fast metabolite mapping based on multiecho balanced SSFP in combination with an iterative reconstruction approach could successfully separate several H-1 resonances and hyperpolarized C-13 metabolites. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Hyperpolarized C-13, IDEAL, Multiecho sequence, Balanced SSFP, Chemical shift imaging
in
Magma
volume
22
issue
4
pages
251 - 256
publisher
Springer
external identifiers
  • wos:000268903800006
  • scopus:68849122929
ISSN
1352-8661
DOI
10.1007/s10334-009-0169-z
language
English
LU publication?
yes
id
ed4a475f-72f6-410f-9526-c957cf790817 (old id 1477222)
date added to LUP
2009-09-23 13:00:33
date last changed
2017-12-10 04:16:26
@article{ed4a475f-72f6-410f-9526-c957cf790817,
  abstract     = {To investigate the feasibility of multiecho balanced steady-state free precession (bSSFP)-based fast chemical shift mapping hyperpolarized C-13 metabolites. The overall goal was to reduce total imaging time and to increase spatial resolution compared to common chemical shift imaging (CSI). A multiecho bSSFP sequence in combination with an iterative reconstruction algorithm was implemented. H-1 experiments were performed on phantoms and on a human volunteer in order to investigate the feasibility of the method on a system with metabolite maps that are known beforehand. C-13 experiments were performed in vivo on pigs, where CSI images were acquired also for comparison. Chemical shift images of three and four distinct H-1 resonance frequencies as well as chemical shift images of up to five hyperpolarized C-13 metabolites were successfully obtained. Fast metabolite mapping based on multiecho balanced SSFP in combination with an iterative reconstruction approach could successfully separate several H-1 resonances and hyperpolarized C-13 metabolites.},
  author       = {Leupold, Jochen and Månsson, Sven and Petersson, J. Stefan and Hennig, Juergen and Wieben, Oliver},
  issn         = {1352-8661},
  keyword      = {Hyperpolarized C-13,IDEAL,Multiecho sequence,Balanced SSFP,Chemical shift imaging},
  language     = {eng},
  number       = {4},
  pages        = {251--256},
  publisher    = {Springer},
  series       = {Magma},
  title        = {Fast multiecho balanced SSFP metabolite mapping of H-1 and hyperpolarized C-13 compounds},
  url          = {http://dx.doi.org/10.1007/s10334-009-0169-z},
  volume       = {22},
  year         = {2009},
}