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Plasma apolipoprotein M is reduced in metabolic syndrome but does not predict intima media thickness

Dullaart, Robin P. F.; Plomgaard, Peter; de Vries, Rindert; Dahlbäck, Björn LU and Nielsen, Lars B. (2009) In Clinica Chimica Acta 406(1-2). p.129-133
Abstract
Background: Apolipoprotein (apo) M may exert anti-atherogenic properties in experimental studies. Its hepatic gene expression may be linked to glucose and lipid metabolism. Plasma apoM is decreased in obese mouse models. We hypothesized that plasma apoM is lower in metabolic syndrome (MetS) subjects, and determined whether intima media thickness (IMT) is associated with apoM. Methods: In 19 non-diabetic subjects with and 60 non-diabetic subjects without MetS (NCEP, ATP III criteria), the relationships of plasma apoM with obesity, glucose, insulin, lipids and adipokines, as well as with IMT were determined. Results: Plasma apoM was on average 15% lower in subjects with MetS compared to subjects without MetS (p=0.036). ApoM correlated... (More)
Background: Apolipoprotein (apo) M may exert anti-atherogenic properties in experimental studies. Its hepatic gene expression may be linked to glucose and lipid metabolism. Plasma apoM is decreased in obese mouse models. We hypothesized that plasma apoM is lower in metabolic syndrome (MetS) subjects, and determined whether intima media thickness (IMT) is associated with apoM. Methods: In 19 non-diabetic subjects with and 60 non-diabetic subjects without MetS (NCEP, ATP III criteria), the relationships of plasma apoM with obesity, glucose, insulin, lipids and adipokines, as well as with IMT were determined. Results: Plasma apoM was on average 15% lower in subjects with MetS compared to subjects without MetS (p=0.036). ApoM correlated inversely with body mass index and waist circumference (p<0.001), and positively with total cholesterol, LDL cholesterol and apoA-I (p<0.05). ApoM was not significantly correlated with glucose, insulin, leptin, adiponectin or resistin (p>0.20). Age- and sex adjusted IMT was lower in subjects with MetS (p<0.05), but was unrelated to apoM (p=0.68). In a multiple linear regression model that included the presence of both MetS and apoM, IMT was only related to MetS (p=0.05). Conclusions: Plasma apoM is reduced in MetS. In this study, apoM did not predict subclinical atherosclerosis. (C) 2009 Elsevier B.V. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Leptin, Apolipoprotein M, Intima media thickness, Metabolic syndrome
in
Clinica Chimica Acta
volume
406
issue
1-2
pages
129 - 133
publisher
Elsevier
external identifiers
  • wos:000268923900027
  • scopus:67650251213
ISSN
0009-8981
DOI
10.1016/j.cca.2009.06.010
language
English
LU publication?
yes
id
dae57d5d-25de-4b13-966b-0c4437230557 (old id 1477354)
date added to LUP
2009-09-23 12:14:43
date last changed
2017-04-23 03:34:31
@article{dae57d5d-25de-4b13-966b-0c4437230557,
  abstract     = {Background: Apolipoprotein (apo) M may exert anti-atherogenic properties in experimental studies. Its hepatic gene expression may be linked to glucose and lipid metabolism. Plasma apoM is decreased in obese mouse models. We hypothesized that plasma apoM is lower in metabolic syndrome (MetS) subjects, and determined whether intima media thickness (IMT) is associated with apoM. Methods: In 19 non-diabetic subjects with and 60 non-diabetic subjects without MetS (NCEP, ATP III criteria), the relationships of plasma apoM with obesity, glucose, insulin, lipids and adipokines, as well as with IMT were determined. Results: Plasma apoM was on average 15% lower in subjects with MetS compared to subjects without MetS (p=0.036). ApoM correlated inversely with body mass index and waist circumference (p&lt;0.001), and positively with total cholesterol, LDL cholesterol and apoA-I (p&lt;0.05). ApoM was not significantly correlated with glucose, insulin, leptin, adiponectin or resistin (p&gt;0.20). Age- and sex adjusted IMT was lower in subjects with MetS (p&lt;0.05), but was unrelated to apoM (p=0.68). In a multiple linear regression model that included the presence of both MetS and apoM, IMT was only related to MetS (p=0.05). Conclusions: Plasma apoM is reduced in MetS. In this study, apoM did not predict subclinical atherosclerosis. (C) 2009 Elsevier B.V. All rights reserved.},
  author       = {Dullaart, Robin P. F. and Plomgaard, Peter and de Vries, Rindert and Dahlbäck, Björn and Nielsen, Lars B.},
  issn         = {0009-8981},
  keyword      = {Leptin,Apolipoprotein M,Intima media thickness,Metabolic syndrome},
  language     = {eng},
  number       = {1-2},
  pages        = {129--133},
  publisher    = {Elsevier},
  series       = {Clinica Chimica Acta},
  title        = {Plasma apolipoprotein M is reduced in metabolic syndrome but does not predict intima media thickness},
  url          = {http://dx.doi.org/10.1016/j.cca.2009.06.010},
  volume       = {406},
  year         = {2009},
}