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Sarcomas With Spindle Cell Morphology

Collini, Paolo; Sorensen, Poul H. B.; Patel, Shreyaskumar; Blay, Jean-Yves; Issels, Rolf D.; Maki, Robert G.; Eriksson, Mikael LU and Garcia del Muro, Xavier (2009) International Symposium on Sarcomas and Gastrointestinal Stromal Tumors In Seminars in Oncology 36(4). p.324-337
Abstract
In the days before the term “high-grade undifferentiated pleomorphic sarcoma” came into use, one of the most common sarcoma diagnoses was “malignant fibrous histiocytoma,” and before that, in an era before immunohistochemistry, “fibrosarcoma” was used to describe most sarcomas. “Spindle cell” is a descriptive phrase that denotes the cellular shape of many of the sarcomas encountered in the adult population. As a result, they are usually treated differently from small round cell sarcomas, and have different biological characteristics than those tumors and sarcomas with epithelioid morphology. As a very broad generalization, sarcomas with a spindle cell microscopic morphology occur in adults and are treated primarily with surgery and often... (More)
In the days before the term “high-grade undifferentiated pleomorphic sarcoma” came into use, one of the most common sarcoma diagnoses was “malignant fibrous histiocytoma,” and before that, in an era before immunohistochemistry, “fibrosarcoma” was used to describe most sarcomas. “Spindle cell” is a descriptive phrase that denotes the cellular shape of many of the sarcomas encountered in the adult population. As a result, they are usually treated differently from small round cell sarcomas, and have different biological characteristics than those tumors and sarcomas with epithelioid morphology. As a very broad generalization, sarcomas with a spindle cell microscopic morphology occur in adults and are treated primarily with surgery and often adjuvant or neoadjuvant radiation as primary therapy. In comparison to small round cell sarcomas such as Ewing sarcoma, the use of adjuvant chemotherapy remains controversial, and the sensitivity of these tumors to chemotherapy in the metastatic setting is highly variable. In this article, we describe some of the clinical and biological characteristics of this group of sarcomas. (Less)
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author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
in
Seminars in Oncology
volume
36
issue
4
pages
324 - 337
publisher
W B Saunders
conference name
International Symposium on Sarcomas and Gastrointestinal Stromal Tumors
external identifiers
  • wos:000268899600005
  • scopus:67949096046
ISSN
0093-7754
DOI
10.1053/j.seminoncol.2009.06.007
language
English
LU publication?
yes
id
263b774b-fb81-4423-8dfb-a95f39715683 (old id 1477522)
date added to LUP
2009-09-22 10:51:47
date last changed
2017-09-24 04:01:11
@inproceedings{263b774b-fb81-4423-8dfb-a95f39715683,
  abstract     = {In the days before the term “high-grade undifferentiated pleomorphic sarcoma” came into use, one of the most common sarcoma diagnoses was “malignant fibrous histiocytoma,” and before that, in an era before immunohistochemistry, “fibrosarcoma” was used to describe most sarcomas. “Spindle cell” is a descriptive phrase that denotes the cellular shape of many of the sarcomas encountered in the adult population. As a result, they are usually treated differently from small round cell sarcomas, and have different biological characteristics than those tumors and sarcomas with epithelioid morphology. As a very broad generalization, sarcomas with a spindle cell microscopic morphology occur in adults and are treated primarily with surgery and often adjuvant or neoadjuvant radiation as primary therapy. In comparison to small round cell sarcomas such as Ewing sarcoma, the use of adjuvant chemotherapy remains controversial, and the sensitivity of these tumors to chemotherapy in the metastatic setting is highly variable. In this article, we describe some of the clinical and biological characteristics of this group of sarcomas.},
  author       = {Collini, Paolo and Sorensen, Poul H. B. and Patel, Shreyaskumar and Blay, Jean-Yves and Issels, Rolf D. and Maki, Robert G. and Eriksson, Mikael and Garcia del Muro, Xavier},
  booktitle    = {Seminars in Oncology},
  issn         = {0093-7754},
  language     = {eng},
  number       = {4},
  pages        = {324--337},
  publisher    = {W B Saunders},
  title        = {Sarcomas With Spindle Cell Morphology},
  url          = {http://dx.doi.org/10.1053/j.seminoncol.2009.06.007},
  volume       = {36},
  year         = {2009},
}