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Twins studies as a model for studies on the interaction between smoking and genetic factors in the development of chronic bronchitis

Svartengren, Magnus; Engström, Gunnar LU ; Anderson, Martin; Hallberg, Jenny; Edula, Goutham; de Verdier, Maria Gerhardsson; Dahlback, Magnus; Lindberg, Claes M.; Forsman-Semb, Kristina and Nihlén, Ulf LU , et al. (2009) Conference on Biochemical Basic of Respiratory Disease In Biochemical Society Transactions 37. p.814-818
Abstract
Smoking is the main risk factor for COPD (chronic obstructive pulmonary disease) but genetic factors are of importance, since only a subset of smokers develops the disease. Sex differences have been suggested both in disease prevalence and response to environmental exposures. Furthermore, it has been shown that acquisition of 'addiction' to smoking is partly genetically mediated. Disease cases and smoking habits were identified in 44919 twins aged > 40 years from the Swedish Twin Registry. Disease was defined as self-reported chronic bronchitis or emphysema, or recurrent cough with phlegm. The results showed that chronic bronchitis seems to be more prevalent among females, and that the heritability estimate for chronic bronchitis was a... (More)
Smoking is the main risk factor for COPD (chronic obstructive pulmonary disease) but genetic factors are of importance, since only a subset of smokers develops the disease. Sex differences have been suggested both in disease prevalence and response to environmental exposures. Furthermore, it has been shown that acquisition of 'addiction' to smoking is partly genetically mediated. Disease cases and smoking habits were identified in 44919 twins aged > 40 years from the Swedish Twin Registry. Disease was defined as self-reported chronic bronchitis or emphysema, or recurrent cough with phlegm. The results showed that chronic bronchitis seems to be more prevalent among females, and that the heritability estimate for chronic bronchitis was a moderate 40% and only 14% of the genetic influences were shared by smoking. In addition, 392 twins have been invited to a clinical investigation to evaluate: (i) to what extent genetic factors contribute to individual differences (variation) in FEV1 (forced expiratory volume in 1 s), vital capacity and l (diffusion capacity), taking sex into consideration, and (ii) whether smoking behaviour and respiratory symptoms influence these estimates. (Less)
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type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
inflammatory marker, chronic obstructive pulmonary disease (COPD), heritability, multi-slice computed tomography (MSCT), smoking, twin
in
Biochemical Society Transactions
volume
37
pages
814 - 818
publisher
Portland Press
conference name
Conference on Biochemical Basic of Respiratory Disease
external identifiers
  • wos:000268902800034
  • scopus:70349306148
ISSN
1470-8752
0300-5127
DOI
10.1042/BST0370814
language
English
LU publication?
yes
id
837ba4cf-b3ba-41cc-b4a2-aa1ce16da701 (old id 1478411)
date added to LUP
2009-09-29 09:43:11
date last changed
2017-01-01 04:31:42
@inproceedings{837ba4cf-b3ba-41cc-b4a2-aa1ce16da701,
  abstract     = {Smoking is the main risk factor for COPD (chronic obstructive pulmonary disease) but genetic factors are of importance, since only a subset of smokers develops the disease. Sex differences have been suggested both in disease prevalence and response to environmental exposures. Furthermore, it has been shown that acquisition of 'addiction' to smoking is partly genetically mediated. Disease cases and smoking habits were identified in 44919 twins aged > 40 years from the Swedish Twin Registry. Disease was defined as self-reported chronic bronchitis or emphysema, or recurrent cough with phlegm. The results showed that chronic bronchitis seems to be more prevalent among females, and that the heritability estimate for chronic bronchitis was a moderate 40% and only 14% of the genetic influences were shared by smoking. In addition, 392 twins have been invited to a clinical investigation to evaluate: (i) to what extent genetic factors contribute to individual differences (variation) in FEV1 (forced expiratory volume in 1 s), vital capacity and l (diffusion capacity), taking sex into consideration, and (ii) whether smoking behaviour and respiratory symptoms influence these estimates.},
  author       = {Svartengren, Magnus and Engström, Gunnar and Anderson, Martin and Hallberg, Jenny and Edula, Goutham and de Verdier, Maria Gerhardsson and Dahlback, Magnus and Lindberg, Claes M. and Forsman-Semb, Kristina and Nihlén, Ulf and Fehniger, Thomas E.},
  booktitle    = {Biochemical Society Transactions},
  issn         = {1470-8752},
  keyword      = {inflammatory marker,chronic obstructive pulmonary disease (COPD),heritability,multi-slice computed tomography (MSCT),smoking,twin},
  language     = {eng},
  pages        = {814--818},
  publisher    = {Portland Press},
  title        = {Twins studies as a model for studies on the interaction between smoking and genetic factors in the development of chronic bronchitis},
  url          = {http://dx.doi.org/10.1042/BST0370814},
  volume       = {37},
  year         = {2009},
}