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Update on biomarkers for amyloid pathology in Alzheimer's disease

Ashton, Nicholas J. ; Schöll, Michael LU ; Heurling, Kerstin ; Gkanatsiou, Eleni ; Portelius, Erik ; Höglund, Kina ; Brinkmalm, Gunnar ; Hye, Abdul ; Blennow, Kaj LU and Zetterberg, Henrik LU (2018) In Biomarkers in Medicine 12(7). p.799-812
Abstract

At the center of Alzheimer's disease pathogenesis is the aberrant aggregation of amyloid-β (Aβ) into oligomers, fibrils and plaques. Effective monitoring of Aβ deposition directly in patients is essential to assist anti-Aβ therapeutics in target engagement and participant selection. In the advent of approved anti-Aβ therapeutics, biomarkers will become of fundamental importance in initiating treatments having disease modifying effects at the earliest stage. Two well-established Aβ biomarkers are widely utilized: Aβ-binding ligands for positron emission tomography and immunoassays to measure Aβ42 in cerebrospinal fluid. In this review, we will discuss the current clinical, diagnostic and research state of biomarkers for Aβ pathology.... (More)

At the center of Alzheimer's disease pathogenesis is the aberrant aggregation of amyloid-β (Aβ) into oligomers, fibrils and plaques. Effective monitoring of Aβ deposition directly in patients is essential to assist anti-Aβ therapeutics in target engagement and participant selection. In the advent of approved anti-Aβ therapeutics, biomarkers will become of fundamental importance in initiating treatments having disease modifying effects at the earliest stage. Two well-established Aβ biomarkers are widely utilized: Aβ-binding ligands for positron emission tomography and immunoassays to measure Aβ42 in cerebrospinal fluid. In this review, we will discuss the current clinical, diagnostic and research state of biomarkers for Aβ pathology. Furthermore, we will explore the current application of blood-based markers to assess Aβ pathology.

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author
; ; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Alzheimer's disease, amyloid-β, Aβ, biomarkers, blood-based biomarkers, cerebrospinal fluid, dementia, positron emission tomography
in
Biomarkers in Medicine
volume
12
issue
7
pages
14 pages
publisher
Future Medicine Ltd.
external identifiers
  • pmid:29902934
  • scopus:85049667477
ISSN
1752-0363
DOI
10.2217/bmm-2017-0433
language
English
LU publication?
yes
id
147e1a68-6dba-4b4a-b804-d7bd427c502e
date added to LUP
2018-07-30 14:26:29
date last changed
2024-04-01 06:55:08
@article{147e1a68-6dba-4b4a-b804-d7bd427c502e,
  abstract     = {{<p>At the center of Alzheimer's disease pathogenesis is the aberrant aggregation of amyloid-β (Aβ) into oligomers, fibrils and plaques. Effective monitoring of Aβ deposition directly in patients is essential to assist anti-Aβ therapeutics in target engagement and participant selection. In the advent of approved anti-Aβ therapeutics, biomarkers will become of fundamental importance in initiating treatments having disease modifying effects at the earliest stage. Two well-established Aβ biomarkers are widely utilized: Aβ-binding ligands for positron emission tomography and immunoassays to measure Aβ42 in cerebrospinal fluid. In this review, we will discuss the current clinical, diagnostic and research state of biomarkers for Aβ pathology. Furthermore, we will explore the current application of blood-based markers to assess Aβ pathology.</p>}},
  author       = {{Ashton, Nicholas J. and Schöll, Michael and Heurling, Kerstin and Gkanatsiou, Eleni and Portelius, Erik and Höglund, Kina and Brinkmalm, Gunnar and Hye, Abdul and Blennow, Kaj and Zetterberg, Henrik}},
  issn         = {{1752-0363}},
  keywords     = {{Alzheimer's disease; amyloid-β; Aβ; biomarkers; blood-based biomarkers; cerebrospinal fluid; dementia; positron emission tomography}},
  language     = {{eng}},
  month        = {{07}},
  number       = {{7}},
  pages        = {{799--812}},
  publisher    = {{Future Medicine Ltd.}},
  series       = {{Biomarkers in Medicine}},
  title        = {{Update on biomarkers for amyloid pathology in Alzheimer's disease}},
  url          = {{http://dx.doi.org/10.2217/bmm-2017-0433}},
  doi          = {{10.2217/bmm-2017-0433}},
  volume       = {{12}},
  year         = {{2018}},
}